Gene Page: PABPC3
Summary ?
| GeneID | 5042 |
| Symbol | PABPC3 |
| Synonyms | PABP3|PABPL3|tPABP |
| Description | poly(A) binding protein, cytoplasmic 3 |
| Reference | MIM:604680|HGNC:HGNC:8556|HPRD:05248| |
| Gene type | protein-coding |
| Map location | 13q12-q13 |
| Pascal p-value | 0.28 |
| Sherlock p-value | 7.698E-4 |
| DMG | 1 (# studies) |
| eGene | Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 2 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg00094319 | 13 | 25670530 | PABPC3 | 4.522E-4 | 0.362 | 0.045 | DMG:Wockner_2014 |
| cg25752797 | 13 | 25670228 | PABPC3 | 4.778E-4 | 0.327 | 0.046 | DMG:Wockner_2014 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs3804338 | chr6 | 106772772 | PABPC3 | 5042 | 0.06 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| CRISPLD1 | 0.78 | 0.74 |
| VCAM1 | 0.75 | 0.64 |
| C5orf33 | 0.74 | 0.72 |
| YES1 | 0.73 | 0.68 |
| RP2 | 0.72 | 0.68 |
| PABPC5 | 0.72 | 0.70 |
| TFPI | 0.72 | 0.60 |
| GNG12 | 0.72 | 0.62 |
| UNC119B | 0.71 | 0.63 |
| ARHGAP12 | 0.71 | 0.69 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| MT-CO2 | -0.38 | -0.44 |
| FXYD1 | -0.38 | -0.42 |
| AF347015.33 | -0.37 | -0.41 |
| CA4 | -0.36 | -0.36 |
| AF347015.8 | -0.36 | -0.42 |
| AC018755.7 | -0.36 | -0.44 |
| S100A1 | -0.36 | -0.37 |
| HLA-F | -0.36 | -0.36 |
| MT-CYB | -0.35 | -0.41 |
| AF347015.27 | -0.35 | -0.39 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| PUIFFE INVASION INHIBITED BY ASCITES UP | 82 | 51 | All SZGR 2.0 genes in this pathway |
| SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN UP | 479 | 299 | All SZGR 2.0 genes in this pathway |
| NUYTTEN NIPP1 TARGETS DN | 848 | 527 | All SZGR 2.0 genes in this pathway |
| BLALOCK ALZHEIMERS DISEASE INCIPIENT UP | 390 | 242 | All SZGR 2.0 genes in this pathway |
| BLALOCK ALZHEIMERS DISEASE UP | 1691 | 1088 | All SZGR 2.0 genes in this pathway |
| GRADE COLON CANCER UP | 871 | 505 | All SZGR 2.0 genes in this pathway |
| GRADE COLON AND RECTAL CANCER UP | 285 | 167 | All SZGR 2.0 genes in this pathway |