Summary ?
GeneID51010
SymbolEXOSC3
SynonymsCGI-102|PCH1B|RRP40|Rrp40p|bA3J10.7|hRrp-40|p10
Descriptionexosome component 3
ReferenceMIM:606489|HGNC:HGNC:17944|Ensembl:ENSG00000107371|HPRD:16220|Vega:OTTHUMG00000019932
Gene typeprotein-coding
Map location9p11
Pascal p-value0.098
Sherlock p-value0.159
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs1364669chr253452494EXOSC3510100.18trans
rs4789947chr1777135790EXOSC3510100.15trans
rs1795952chr1777136677EXOSC3510100.15trans
rs2707040chr1777136833EXOSC3510100.15trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
DIS3DKFZp667L1817 | EXOSC11 | FLJ10484 | KIAA1008 | MGC33035 | RP11-342J4.3 | RRP44 | bA555G22.1 | dis3pDIS3 mitotic control homolog (S. cerevisiae)-HPRD12419256 
EXOSC1CGI-108 | CSL4 | Csl4p | SKI4 | Ski4p | hCsl4p | p13exosome component 1-HPRD11812149 |12419256 
EXOSC10PM-Scl | PM/Scl-100 | PMSCL | PMSCL2 | RRP6 | Rrp6p | p2 | p3 | p4exosome component 10-HPRD11110791 |12419256 
EXOSC2RRP4 | Rrp4p | hRrp4p | p7exosome component 2-HPRD11110791 |12419256 
EXOSC4FLJ20591 | RRP41 | RRP41A | Rrp41p | SKI6 | Ski6p | hRrp41p | p12Aexosome component 4-HPRD11110791 |12419256 
EXOSC5MGC111224 | MGC12901 | RRP41B | RRP46 | Rrp46p | hRrp46p | p12Bexosome component 5-HPRD11110791 |12419256|12419256 
EXOSC5MGC111224 | MGC12901 | RRP41B | RRP46 | Rrp46p | hRrp46p | p12Bexosome component 5hRrp40p interacts with hRrp46p.BIND12419256 
EXOSC6EAP4 | MTR3 | Mtr3p | hMtr3p | p11exosome component 6-HPRD12419256 
EXOSC7EAP1 | FLJ26543 | KIAA0116 | RRP42 | Rrp42p | hRrp42p | p8exosome component 7-HPRD11879549 |12419256 
EXOSC8CIP3 | EAP2 | OIP2 | RP11-421P11.3 | RRP43 | Rrp43p | bA421P11.3 | p9exosome component 8-HPRD12419256 
EXOSC9PM/Scl-75 | PMSCL1 | RRP45 | Rrp45p | p5 | p6exosome component 9-HPRD12419256 
KHSRPFBP2 | FUBP2 | KSRP | MGC99676KH-type splicing regulatory protein-HPRD11719186 |15175153|15175153 
KHSRPFBP2 | FUBP2 | KSRP | MGC99676KH-type splicing regulatory proteinKSRP interacts with hRrp40p.BIND15175153 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG RNA DEGRADATION 5937All SZGR 2.0 genes in this pathway
REACTOME DIABETES PATHWAYS 13391All SZGR 2.0 genes in this pathway
REACTOME PERK REGULATED GENE EXPRESSION 2914All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF GENES BY ATF4 2612All SZGR 2.0 genes in this pathway
REACTOME UNFOLDED PROTEIN RESPONSE 8051All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF MRNA 284128All SZGR 2.0 genes in this pathway
REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 115All SZGR 2.0 genes in this pathway
REACTOME DEADENYLATION DEPENDENT MRNA DECAY 4829All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF RNA 330155All SZGR 2.0 genes in this pathway
REACTOME DESTABILIZATION OF MRNA BY BRF1 179All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS 8450All SZGR 2.0 genes in this pathway
REACTOME DESTABILIZATION OF MRNA BY KSRP 179All SZGR 2.0 genes in this pathway
REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP 177All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278748All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN 1024594All SZGR 2.0 genes in this pathway
WEI MYCN TARGETS WITH E BOX 795478All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR DN 911527All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR DN 1011592All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP 973570All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP 863514All SZGR 2.0 genes in this pathway
MUELLER PLURINET 299189All SZGR 2.0 genes in this pathway
FIGUEROA AML METHYLATION CLUSTER 2 UP 5431All SZGR 2.0 genes in this pathway
FIGUEROA AML METHYLATION CLUSTER 3 UP 17097All SZGR 2.0 genes in this pathway
FIGUEROA AML METHYLATION CLUSTER 4 UP 11264All SZGR 2.0 genes in this pathway
FIGUEROA AML METHYLATION CLUSTER 6 UP 14081All SZGR 2.0 genes in this pathway
FIGUEROA AML METHYLATION CLUSTER 7 UP 11868All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 19721213All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN 918550All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE 1137655All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 AND SATB1 DN 180116All SZGR 2.0 genes in this pathway