Gene Page: RPS27L
Summary ?
| GeneID | 51065 |
| Symbol | RPS27L |
| Synonyms | - |
| Description | ribosomal protein S27 like |
| Reference | MIM:612055|HGNC:HGNC:18476|HPRD:18003| |
| Gene type | protein-coding |
| Map location | 15q22.2 |
| Pascal p-value | 0.002 |
| Sherlock p-value | 0.269 |
| eGene | Anterior cingulate cortex BA24 Caudate basal ganglia Cerebellar Hemisphere Cerebellum Cortex Frontal Cortex BA9 Hippocampus Hypothalamus Nucleus accumbens basal ganglia Putamen basal ganglia Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs71393126 | 15 | 63394010 | RPS27L | ENSG00000185088.8 | 8.396E-7 | 0 | 56210 | gtex_brain_ba24 |
| rs9788649 | 15 | 63422817 | RPS27L | ENSG00000185088.8 | 7.48E-8 | 0 | 27403 | gtex_brain_ba24 |
| rs8039716 | 15 | 63431286 | RPS27L | ENSG00000185088.8 | 1.573E-10 | 0 | 18934 | gtex_brain_ba24 |
| rs2088929 | 15 | 63432495 | RPS27L | ENSG00000185088.8 | 1.579E-10 | 0 | 17725 | gtex_brain_ba24 |
| rs12898885 | 15 | 63435129 | RPS27L | ENSG00000185088.8 | 2.387E-9 | 0 | 15091 | gtex_brain_ba24 |
| rs12899931 | 15 | 63435196 | RPS27L | ENSG00000185088.8 | 1.579E-10 | 0 | 15024 | gtex_brain_ba24 |
| rs8027689 | 15 | 63436518 | RPS27L | ENSG00000185088.8 | 1.579E-10 | 0 | 13702 | gtex_brain_ba24 |
| rs2729812 | 15 | 63436628 | RPS27L | ENSG00000185088.8 | 1.756E-7 | 0 | 13592 | gtex_brain_ba24 |
| rs7172351 | 15 | 63437047 | RPS27L | ENSG00000185088.8 | 1.579E-10 | 0 | 13173 | gtex_brain_ba24 |
| rs59322122 | 15 | 63437539 | RPS27L | ENSG00000185088.8 | 1.579E-10 | 0 | 12681 | gtex_brain_ba24 |
| rs34738270 | 15 | 63438372 | RPS27L | ENSG00000185088.8 | 1.579E-10 | 0 | 11848 | gtex_brain_ba24 |
| rs34661422 | 15 | 63438404 | RPS27L | ENSG00000185088.8 | 1.579E-10 | 0 | 11816 | gtex_brain_ba24 |
| rs28679339 | 15 | 63438601 | RPS27L | ENSG00000185088.8 | 2.387E-9 | 0 | 11619 | gtex_brain_ba24 |
| rs28363750 | 15 | 63438772 | RPS27L | ENSG00000185088.8 | 1.579E-10 | 0 | 11448 | gtex_brain_ba24 |
| rs28850420 | 15 | 63438974 | RPS27L | ENSG00000185088.8 | 2.424E-9 | 0 | 11246 | gtex_brain_ba24 |
| rs7169792 | 15 | 63440483 | RPS27L | ENSG00000185088.8 | 1.579E-10 | 0 | 9737 | gtex_brain_ba24 |
| rs7169648 | 15 | 63440515 | RPS27L | ENSG00000185088.8 | 1.218E-10 | 0 | 9705 | gtex_brain_ba24 |
| rs200545481 | 15 | 63440599 | RPS27L | ENSG00000185088.8 | 1.218E-10 | 0 | 9621 | gtex_brain_ba24 |
| rs201476446 | 15 | 63440600 | RPS27L | ENSG00000185088.8 | 1.942E-9 | 0 | 9620 | gtex_brain_ba24 |
| rs6494395 | 15 | 63441055 | RPS27L | ENSG00000185088.8 | 3.945E-11 | 0 | 9165 | gtex_brain_ba24 |
| rs28588736 | 15 | 63441810 | RPS27L | ENSG00000185088.8 | 2.246E-10 | 0 | 8410 | gtex_brain_ba24 |
| rs28394803 | 15 | 63443968 | RPS27L | ENSG00000185088.8 | 2.387E-9 | 0 | 6252 | gtex_brain_ba24 |
| rs28678549 | 15 | 63444349 | RPS27L | ENSG00000185088.8 | 1.579E-10 | 0 | 5871 | gtex_brain_ba24 |
| rs57838635 | 15 | 63444715 | RPS27L | ENSG00000185088.8 | 1.636E-10 | 0 | 5505 | gtex_brain_ba24 |
| rs953978 | 15 | 63445144 | RPS27L | ENSG00000185088.8 | 2.387E-9 | 0 | 5076 | gtex_brain_ba24 |
| rs28434769 | 15 | 63445764 | RPS27L | ENSG00000185088.8 | 1.579E-10 | 0 | 4456 | gtex_brain_ba24 |
| rs28542166 | 15 | 63445872 | RPS27L | ENSG00000185088.8 | 1.528E-10 | 0 | 4348 | gtex_brain_ba24 |
| rs28637229 | 15 | 63446012 | RPS27L | ENSG00000185088.8 | 1.579E-10 | 0 | 4208 | gtex_brain_ba24 |
| rs59953192 | 15 | 63446199 | RPS27L | ENSG00000185088.8 | 1.565E-10 | 0 | 4021 | gtex_brain_ba24 |
| rs35018260 | 15 | 63446332 | RPS27L | ENSG00000185088.8 | 7.742E-8 | 0 | 3888 | gtex_brain_ba24 |
| rs28562564 | 15 | 63446598 | RPS27L | ENSG00000185088.8 | 1.579E-10 | 0 | 3622 | gtex_brain_ba24 |
| rs8182067 | 15 | 63446934 | RPS27L | ENSG00000185088.8 | 1.302E-10 | 0 | 3286 | gtex_brain_ba24 |
| rs3784677 | 15 | 63447198 | RPS27L | ENSG00000185088.8 | 1.13E-10 | 0 | 3022 | gtex_brain_ba24 |
| rs28479880 | 15 | 63448154 | RPS27L | ENSG00000185088.8 | 7.436E-11 | 0 | 2066 | gtex_brain_ba24 |
| rs11853249 | 15 | 63448471 | RPS27L | ENSG00000185088.8 | 6.7E-11 | 0 | 1749 | gtex_brain_ba24 |
| rs2270948 | 15 | 63448780 | RPS27L | ENSG00000185088.8 | 6.479E-11 | 0 | 1440 | gtex_brain_ba24 |
| rs28377261 | 15 | 63449005 | RPS27L | ENSG00000185088.8 | 6.161E-11 | 0 | 1215 | gtex_brain_ba24 |
| rs12902921 | 15 | 63449777 | RPS27L | ENSG00000185088.8 | 5.575E-11 | 0 | 443 | gtex_brain_ba24 |
| rs8036501 | 15 | 63449865 | RPS27L | ENSG00000185088.8 | 3.828E-8 | 0 | 355 | gtex_brain_ba24 |
| rs8039273 | 15 | 63461363 | RPS27L | ENSG00000185088.8 | 6.843E-11 | 0 | -11143 | gtex_brain_ba24 |
| rs11071734 | 15 | 63462617 | RPS27L | ENSG00000185088.8 | 5.813E-8 | 0 | -12397 | gtex_brain_ba24 |
| rs12903970 | 15 | 63466226 | RPS27L | ENSG00000185088.8 | 1.393E-7 | 0 | -16006 | gtex_brain_ba24 |
| rs71393135 | 15 | 63466863 | RPS27L | ENSG00000185088.8 | 1.317E-7 | 0 | -16643 | gtex_brain_ba24 |
| rs34605284 | 15 | 63391465 | RPS27L | ENSG00000185088.8 | 5.038E-7 | 0 | 58755 | gtex_brain_putamen_basal |
| rs71393126 | 15 | 63394010 | RPS27L | ENSG00000185088.8 | 2.802E-7 | 0 | 56210 | gtex_brain_putamen_basal |
| rs35467520 | 15 | 63397560 | RPS27L | ENSG00000185088.8 | 2.965E-7 | 0 | 52660 | gtex_brain_putamen_basal |
| rs9788649 | 15 | 63422817 | RPS27L | ENSG00000185088.8 | 1.095E-10 | 0 | 27403 | gtex_brain_putamen_basal |
| rs8039716 | 15 | 63431286 | RPS27L | ENSG00000185088.8 | 1.109E-9 | 0 | 18934 | gtex_brain_putamen_basal |
| rs2088929 | 15 | 63432495 | RPS27L | ENSG00000185088.8 | 1.109E-9 | 0 | 17725 | gtex_brain_putamen_basal |
| rs12898885 | 15 | 63435129 | RPS27L | ENSG00000185088.8 | 4.975E-9 | 0 | 15091 | gtex_brain_putamen_basal |
| rs12899931 | 15 | 63435196 | RPS27L | ENSG00000185088.8 | 1.109E-9 | 0 | 15024 | gtex_brain_putamen_basal |
| rs8027689 | 15 | 63436518 | RPS27L | ENSG00000185088.8 | 1.087E-10 | 0 | 13702 | gtex_brain_putamen_basal |
| rs7172351 | 15 | 63437047 | RPS27L | ENSG00000185088.8 | 1.087E-10 | 0 | 13173 | gtex_brain_putamen_basal |
| rs59322122 | 15 | 63437539 | RPS27L | ENSG00000185088.8 | 1.087E-10 | 0 | 12681 | gtex_brain_putamen_basal |
| rs34738270 | 15 | 63438372 | RPS27L | ENSG00000185088.8 | 1.087E-10 | 0 | 11848 | gtex_brain_putamen_basal |
| rs34661422 | 15 | 63438404 | RPS27L | ENSG00000185088.8 | 1.087E-10 | 0 | 11816 | gtex_brain_putamen_basal |
| rs28679339 | 15 | 63438601 | RPS27L | ENSG00000185088.8 | 7.356E-10 | 0 | 11619 | gtex_brain_putamen_basal |
| rs28363750 | 15 | 63438772 | RPS27L | ENSG00000185088.8 | 1.087E-10 | 0 | 11448 | gtex_brain_putamen_basal |
| rs28850420 | 15 | 63438974 | RPS27L | ENSG00000185088.8 | 8.191E-10 | 0 | 11246 | gtex_brain_putamen_basal |
| rs7169792 | 15 | 63440483 | RPS27L | ENSG00000185088.8 | 1.087E-10 | 0 | 9737 | gtex_brain_putamen_basal |
| rs7169648 | 15 | 63440515 | RPS27L | ENSG00000185088.8 | 9.169E-11 | 0 | 9705 | gtex_brain_putamen_basal |
| rs200545481 | 15 | 63440599 | RPS27L | ENSG00000185088.8 | 9.169E-11 | 0 | 9621 | gtex_brain_putamen_basal |
| rs201476446 | 15 | 63440600 | RPS27L | ENSG00000185088.8 | 6.347E-10 | 0 | 9620 | gtex_brain_putamen_basal |
| rs6494395 | 15 | 63441055 | RPS27L | ENSG00000185088.8 | 5.927E-10 | 0 | 9165 | gtex_brain_putamen_basal |
| rs28588736 | 15 | 63441810 | RPS27L | ENSG00000185088.8 | 6.323E-11 | 0 | 8410 | gtex_brain_putamen_basal |
| rs28394803 | 15 | 63443968 | RPS27L | ENSG00000185088.8 | 7.356E-10 | 0 | 6252 | gtex_brain_putamen_basal |
| rs28678549 | 15 | 63444349 | RPS27L | ENSG00000185088.8 | 1.087E-10 | 0 | 5871 | gtex_brain_putamen_basal |
| rs57838635 | 15 | 63444715 | RPS27L | ENSG00000185088.8 | 1.185E-10 | 0 | 5505 | gtex_brain_putamen_basal |
| rs398102528 | 15 | 63444868 | RPS27L | ENSG00000185088.8 | 1.206E-8 | 0 | 5352 | gtex_brain_putamen_basal |
| rs953978 | 15 | 63445144 | RPS27L | ENSG00000185088.8 | 7.356E-10 | 0 | 5076 | gtex_brain_putamen_basal |
| rs28434769 | 15 | 63445764 | RPS27L | ENSG00000185088.8 | 1.087E-10 | 0 | 4456 | gtex_brain_putamen_basal |
| rs28542166 | 15 | 63445872 | RPS27L | ENSG00000185088.8 | 1.882E-10 | 0 | 4348 | gtex_brain_putamen_basal |
| rs28637229 | 15 | 63446012 | RPS27L | ENSG00000185088.8 | 1.087E-10 | 0 | 4208 | gtex_brain_putamen_basal |
| rs59953192 | 15 | 63446199 | RPS27L | ENSG00000185088.8 | 1.094E-10 | 0 | 4021 | gtex_brain_putamen_basal |
| rs35018260 | 15 | 63446332 | RPS27L | ENSG00000185088.8 | 1.089E-10 | 0 | 3888 | gtex_brain_putamen_basal |
| rs28562564 | 15 | 63446598 | RPS27L | ENSG00000185088.8 | 1.087E-10 | 0 | 3622 | gtex_brain_putamen_basal |
| rs8182067 | 15 | 63446934 | RPS27L | ENSG00000185088.8 | 9.795E-11 | 0 | 3286 | gtex_brain_putamen_basal |
| rs3784677 | 15 | 63447198 | RPS27L | ENSG00000185088.8 | 9.102E-11 | 0 | 3022 | gtex_brain_putamen_basal |
| rs28479880 | 15 | 63448154 | RPS27L | ENSG00000185088.8 | 7.528E-11 | 0 | 2066 | gtex_brain_putamen_basal |
| rs11853249 | 15 | 63448471 | RPS27L | ENSG00000185088.8 | 7.257E-11 | 0 | 1749 | gtex_brain_putamen_basal |
| rs2270948 | 15 | 63448780 | RPS27L | ENSG00000185088.8 | 5.493E-11 | 0 | 1440 | gtex_brain_putamen_basal |
| rs28377261 | 15 | 63449005 | RPS27L | ENSG00000185088.8 | 5.438E-11 | 0 | 1215 | gtex_brain_putamen_basal |
| rs12902921 | 15 | 63449777 | RPS27L | ENSG00000185088.8 | 5.549E-11 | 0 | 443 | gtex_brain_putamen_basal |
| rs8036501 | 15 | 63449865 | RPS27L | ENSG00000185088.8 | 5.59E-11 | 0 | 355 | gtex_brain_putamen_basal |
| rs8039273 | 15 | 63461363 | RPS27L | ENSG00000185088.8 | 6.577E-7 | 0 | -11143 | gtex_brain_putamen_basal |
| rs11071734 | 15 | 63462617 | RPS27L | ENSG00000185088.8 | 7.703E-7 | 0 | -12397 | gtex_brain_putamen_basal |
| rs12903970 | 15 | 63466226 | RPS27L | ENSG00000185088.8 | 6.594E-7 | 0 | -16006 | gtex_brain_putamen_basal |
| rs71393135 | 15 | 63466863 | RPS27L | ENSG00000185088.8 | 6.59E-7 | 0 | -16643 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG RIBOSOME | 88 | 43 | All SZGR 2.0 genes in this pathway |
| PID P53 DOWNSTREAM PATHWAY | 137 | 94 | All SZGR 2.0 genes in this pathway |
| CHANDRAN METASTASIS TOP50 DN | 45 | 26 | All SZGR 2.0 genes in this pathway |
| DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP | 1382 | 904 | All SZGR 2.0 genes in this pathway |
| VECCHI GASTRIC CANCER ADVANCED VS EARLY DN | 138 | 70 | All SZGR 2.0 genes in this pathway |
| HOEBEKE LYMPHOID STEM CELL DN | 86 | 59 | All SZGR 2.0 genes in this pathway |
| KINSEY TARGETS OF EWSR1 FLII FUSION UP | 1278 | 748 | All SZGR 2.0 genes in this pathway |
| WAMUNYOKOLI OVARIAN CANCER LMP UP | 265 | 158 | All SZGR 2.0 genes in this pathway |
| WAMUNYOKOLI OVARIAN CANCER GRADES 1 2 UP | 137 | 84 | All SZGR 2.0 genes in this pathway |
| LINDGREN BLADDER CANCER CLUSTER 1 DN | 378 | 231 | All SZGR 2.0 genes in this pathway |
| KERLEY RESPONSE TO CISPLATIN UP | 44 | 30 | All SZGR 2.0 genes in this pathway |
| JOHANSSON GLIOMAGENESIS BY PDGFB UP | 58 | 44 | All SZGR 2.0 genes in this pathway |
| KIM MYC AMPLIFICATION TARGETS UP | 201 | 127 | All SZGR 2.0 genes in this pathway |
| SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN UP | 479 | 299 | All SZGR 2.0 genes in this pathway |
| LOPEZ MBD TARGETS | 957 | 597 | All SZGR 2.0 genes in this pathway |
| BENPORATH MYC MAX TARGETS | 775 | 494 | All SZGR 2.0 genes in this pathway |
| SHEPARD CRUSH AND BURN MUTANT UP | 197 | 110 | All SZGR 2.0 genes in this pathway |
| WEBER METHYLATED IN COLON CANCER | 18 | 13 | All SZGR 2.0 genes in this pathway |
| RODWELL AGING KIDNEY NO BLOOD UP | 222 | 139 | All SZGR 2.0 genes in this pathway |
| RODWELL AGING KIDNEY UP | 487 | 303 | All SZGR 2.0 genes in this pathway |
| JIANG HYPOXIA NORMAL | 311 | 205 | All SZGR 2.0 genes in this pathway |
| CAIRO HEPATOBLASTOMA CLASSES DN | 210 | 141 | All SZGR 2.0 genes in this pathway |
| DANG BOUND BY MYC | 1103 | 714 | All SZGR 2.0 genes in this pathway |
| CHANDRAN METASTASIS DN | 306 | 191 | All SZGR 2.0 genes in this pathway |
| WARTERS RESPONSE TO IR SKIN | 83 | 44 | All SZGR 2.0 genes in this pathway |