SZGR2

Summary ?

GeneID	5111
Symbol	PCNA
Synonyms	ATLD2
Description	proliferating cell nuclear antigen
Reference	MIM:176740\|HGNC:HGNC:8729\|Ensembl:ENSG00000132646\|HPRD:01456\|Vega:OTTHUMG00000031798
Gene type	protein-coding
Map location	20pter-p12
Pascal p-value	0.388
Sherlock p-value	0.653
Fetal beta	2.024
eGene	Cerebellar Hemisphere Myers' cis & trans

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias	Click to show details
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.0044

Section I. Genetics and epigenetics annotation

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	pvalue	qvalue	TSS distance	eQTL type
rs1578978	chr8	118196802	PCNA	5111		0.18		trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
C1orf183	0.88	0.79
PITPNM2	0.86	0.75
KIAA1045	0.86	0.76
IQSEC2	0.85	0.79
PITPNM3	0.85	0.83
GARNL4	0.85	0.70
NOS2	0.85	0.74
TMEM132D	0.84	0.77
LRRK1	0.84	0.81
CTSB	0.84	0.74

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
BCL7C	-0.47	-0.61
HEBP2	-0.47	-0.66
RPS6	-0.46	-0.60
RPL23A	-0.45	-0.59
RPL18	-0.45	-0.62
RPS19P3	-0.45	-0.62
C9orf46	-0.45	-0.55
RPS3P3	-0.44	-0.57
RPL19P12	-0.44	-0.57
RPL32	-0.44	-0.57

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0003677	DNA binding	IEA		-
GO:0005515	protein binding	IPI		9305916 \|15225546 \|15358233
GO:0032405	MutLalpha complex binding	IDA		11005803
GO:0030337	DNA polymerase processivity factor activity	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0006297	nucleotide-excision repair, DNA gap filling	EXP		9111189
GO:0006287	base-excision repair, gap-filling	IEA		-
GO:0006281	DNA repair	NAS		15504738
GO:0006275	regulation of DNA replication	IEA		-
GO:0008283	cell proliferation	TAS		2565339
GO:0048015	phosphoinositide-mediated signaling	NAS		15504738
GO:0006886	intracellular protein transport	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000307	cyclin-dependent protein kinase holoenzyme complex	IEA		-
GO:0005634	nucleus	IEA		-
GO:0005652	nuclear lamina	IEA		-
GO:0005654	nucleoplasm	EXP		9822671 \|11473323
GO:0005663	DNA replication factor C complex	TAS		2565339
GO:0043626	PCNA complex	IEA		-

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ANXA2	ANX2 \| ANX2L4 \| CAL1H \| LIP2 \| LPC2 \| LPC2D \| P36 \| PAP-IV	annexin A2	-	HPRD,BioGRID	9228079 \|12171929
APEX1	APE \| APE-1 \| APE1 \| APEN \| APEX \| APX \| HAP1 \| REF-1 \| REF1	APEX nuclease (multifunctional DNA repair enzyme) 1	-	HPRD,BioGRID	11601988
APEX2	APE2 \| APEXL2 \| XTH2	APEX nuclease (apurinic/apyrimidinic endonuclease) 2	-	HPRD,BioGRID	11376153
APEX2	APE2 \| APEXL2 \| XTH2	APEX nuclease (apurinic/apyrimidinic endonuclease) 2	APE2 is a PCNA-binding protein	BIND	11376153
BAZ1B	WBSCR10 \| WBSCR9 \| WSTF	bromodomain adjacent to zinc finger domain, 1B	PCNA interacts with WSTF	BIND	15543136
CCNA2	CCN1 \| CCNA	cyclin A2	Affinity Capture-Western	BioGRID	12853968
CCNB1	CCNB	cyclin B1	-	HPRD,BioGRID	8101826
CCND1	BCL1 \| D11S287E \| PRAD1 \| U21B31	cyclin D1	Reconstituted Complex	BioGRID	7908906
CCND3	-	cyclin D3	-	HPRD,BioGRID	7908906
CCNO	CCNU \| FLJ22422 \| UDG2 \| UNG2	cyclin O	-	HPRD,BioGRID	10393198 \|12171929
CDC2	CDC28A \| CDK1 \| DKFZp686L20222 \| MGC111195	cell division cycle 2, G1 to S and G2 to M	-	HPRD	7949095
CDC25C	CDC25	cell division cycle 25 homolog C (S. pombe)	-	HPRD,BioGRID	11896603
CDC6	CDC18L \| HsCDC18 \| HsCDC6	cell division cycle 6 homolog (S. cerevisiae)	-	HPRD,BioGRID	9566895
CDK2	p33(CDK2)	cyclin-dependent kinase 2	-	HPRD,BioGRID	10930425
CDK4	CMM3 \| MGC14458 \| PSK-J3	cyclin-dependent kinase 4	Affinity Capture-Western	BioGRID	8259215
CDK5	PSSALRE	cyclin-dependent kinase 5	-	HPRD	7949095
CDK6	MGC59692 \| PLSTIRE \| STQTL11	cyclin-dependent kinase 6	-	HPRD	9667749
CDKN1A	CAP20 \| CDKN1 \| CIP1 \| MDA-6 \| P21 \| SDI1 \| WAF1 \| p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	CDKN1A (p21) interacts with PCNA.	BIND	8662825
CDKN1A	CAP20 \| CDKN1 \| CIP1 \| MDA-6 \| P21 \| SDI1 \| WAF1 \| p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	p21WAF1 interacts with PCNA.	BIND	7780738
CDKN1A	CAP20 \| CDKN1 \| CIP1 \| MDA-6 \| P21 \| SDI1 \| WAF1 \| p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	PCNA interacts with p21.	BIND	9705499
CDKN1A	CAP20 \| CDKN1 \| CIP1 \| MDA-6 \| P21 \| SDI1 \| WAF1 \| p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	PCNA interacts with p21.	BIND	9178907
CDKN1A	CAP20 \| CDKN1 \| CIP1 \| MDA-6 \| P21 \| SDI1 \| WAF1 \| p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	p21 interacts with PCNA.	BIND	11302688
CDKN1A	CAP20 \| CDKN1 \| CIP1 \| MDA-6 \| P21 \| SDI1 \| WAF1 \| p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	PCNA interacts with p21.	BIND	8861969
CDKN1A	CAP20 \| CDKN1 \| CIP1 \| MDA-6 \| P21 \| SDI1 \| WAF1 \| p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	p21 interacts with PCNA.	BIND	9632134
CDKN1A	CAP20 \| CDKN1 \| CIP1 \| MDA-6 \| P21 \| SDI1 \| WAF1 \| p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	p21 interacts with PCNA. This interaction was modeled on a demonstrated interaction between human p21 and PCNA from an unspecified species.	BIND	9546435
CDKN1A	CAP20 \| CDKN1 \| CIP1 \| MDA-6 \| P21 \| SDI1 \| WAF1 \| p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	-	HPRD,BioGRID	8861913
CDKN1A	CAP20 \| CDKN1 \| CIP1 \| MDA-6 \| P21 \| SDI1 \| WAF1 \| p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	p21WAF1 interacts with PCNA. This interaction was modeled on a demonstrated interaction between human p21WAF1 and Pisum sativum v. Onward PCNA.	BIND	8647134
CDKN1A	CAP20 \| CDKN1 \| CIP1 \| MDA-6 \| P21 \| SDI1 \| WAF1 \| p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	p21 interacts with PCNA. This interaction was modeled on a demonstrated interaction between human p21 and hamster PCNA.	BIND	9467962
CDKN1C	BWCR \| BWS \| KIP2 \| WBS \| p57	cyclin-dependent kinase inhibitor 1C (p57, Kip2)	-	HPRD,BioGRID	9465025
CHAF1A	CAF-1 \| CAF1 \| CAF1B \| CAF1P150 \| MGC71229 \| P150	chromatin assembly factor 1, subunit A (p150)	-	HPRD,BioGRID	10648606
CHTF18	C16orf41 \| C321D2.2 \| C321D2.3 \| C321D2.4 \| CHL12 \| Ctf18 \| RUVBL	CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)	-	HPRD	12766176
CHTF18	C16orf41 \| C321D2.2 \| C321D2.3 \| C321D2.4 \| CHL12 \| Ctf18 \| RUVBL	CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)	-	HPRD,BioGRID	12171929
CTF8	DERPC \| FLJ20400	chromosome transmission fidelity factor 8 homolog (S. cerevisiae)	-	HPRD	12766176
DDX17	DKFZp761H2016 \| P72 \| RH70	DEAD (Asp-Glu-Ala-Asp) box polypeptide 17	DDX17 is a PCNA-binding protein	BIND	12171929
DHX9	DDX9 \| LKP \| NDHII \| RHA	DEAH (Asp-Glu-Ala-His) box polypeptide 9	-	HPRD	12171929
DNMT1	AIM \| CXXC9 \| DNMT \| FLJ16293 \| MCMT \| MGC104992	DNA (cytosine-5-)-methyltransferase 1	Affinity Capture-Western Reconstituted Complex	BioGRID	9302295 \|10888872 \|12354094
DNMT1	AIM \| CXXC9 \| DNMT \| FLJ16293 \| MCMT \| MGC104992	DNA (cytosine-5-)-methyltransferase 1	DNMT1 is a PCNA-binding protein	BIND	12171929
DNMT1	AIM \| CXXC9 \| DNMT \| FLJ16293 \| MCMT \| MGC104992	DNA (cytosine-5-)-methyltransferase 1	-	HPRD	9302295 \|12354094
DNTT	TDT	deoxynucleotidyltransferase, terminal	Co-purification Reconstituted Complex Two-hybrid	BioGRID	11554927
DNTTIP2	ERBP \| FCF2 \| HSU15552 \| LPTS-RP2 \| MGC163494 \| RP4-561L24.1 \| TdIF2	deoxynucleotidyltransferase, terminal, interacting protein 2	-	HPRD	12786946
DSCC1	DCC1 \| MGC5528 \| hDCC1	defective in sister chromatid cohesion 1 homolog (S. cerevisiae)	-	HPRD	12766176
DSCC1	DCC1 \| MGC5528 \| hDCC1	defective in sister chromatid cohesion 1 homolog (S. cerevisiae)	Hypothetical protein MGC5528 is a PCNA-binding protein.	BIND	12171929
EP300	KAT3B \| p300	E1A binding protein p300	-	HPRD,BioGRID	11268218
ERCC5	COFS3 \| ERCM2 \| UVDR \| XPG \| XPGC	excision repair cross-complementing rodent repair deficiency, complementation group 5	-	HPRD,BioGRID	9305916 \|10408173
EXO1	HEX1 \| hExoI	exonuclease 1	PCNA interacts with EXO1b.	BIND	15225546
FEN1	FEN-1 \| MF1 \| RAD2	flap structure-specific endonuclease 1	PCNA interacts with Fen1. This interaction was modeled on a demonstrated interaction between human PCNA and Fen1 from an unspecified species.	BIND	9705499
FEN1	FEN-1 \| MF1 \| RAD2	flap structure-specific endonuclease 1	PCNA interacts with Fen1.	BIND	9178907
FEN1	FEN-1 \| MF1 \| RAD2	flap structure-specific endonuclease 1	Affinity Capture-Western Co-purification Reconstituted Complex Two-hybrid	BioGRID	8876181 \|9305916 \|9545252 \|11430825 \|11601988 \|12853968
FEN1	FEN-1 \| MF1 \| RAD2	flap structure-specific endonuclease 1	FEN1 is a PCNA-binding protein	BIND	12171929
FEN1	FEN-1 \| MF1 \| RAD2	flap structure-specific endonuclease 1	-	HPRD	1477073 \|8876181 \|9305916 \|9545252 \|11430825
GADD45A	DDIT1 \| GADD45	growth arrest and DNA-damage-inducible, alpha	PCNA interacts with Gadd45.	BIND	9705499
GADD45A	DDIT1 \| GADD45	growth arrest and DNA-damage-inducible, alpha	PCNA interacts with Gadd45.	BIND	9178907
GADD45A	DDIT1 \| GADD45	growth arrest and DNA-damage-inducible, alpha	Gadd45a interacts with PCNA. This interaction was modeled on a demonstrated interaction between Gadd45a from an unspecified species and human PCNA.	BIND	12124778
GADD45A	DDIT1 \| GADD45	growth arrest and DNA-damage-inducible, alpha	-	HPRD,BioGRID	7973727 \|10828065
GADD45A	DDIT1 \| GADD45	growth arrest and DNA-damage-inducible, alpha	GADD45 interacts with PCNA.	BIND	10828065
GADD45B	DKFZp566B133 \| GADD45BETA \| MYD118	growth arrest and DNA-damage-inducible, beta	-	HPRD	10828065
GADD45B	DKFZp566B133 \| GADD45BETA \| MYD118	growth arrest and DNA-damage-inducible, beta	MYD118 interacts with PCNA.	BIND	10828065
GADD45B	DKFZp566B133 \| GADD45BETA \| MYD118	growth arrest and DNA-damage-inducible, beta	Gadd45b interacts with PCNA. This interaction was modeled on a demonstrated interaction between Gadd45b from an unspecified species and human PCNA.	BIND	12124778
GADD45G	CR6 \| DDIT2 \| GADD45gamma \| GRP17	growth arrest and DNA-damage-inducible, gamma	Gadd45g interacts with PCNA. This interaction was modeled on a demonstrated interaction between Gadd45g from an unspecified species and human PCNA.	BIND	12124778
GADD45G	CR6 \| DDIT2 \| GADD45gamma \| GRP17	growth arrest and DNA-damage-inducible, gamma	-	HPRD,BioGRID	10455148 \|11022036
HDAC1	DKFZp686H12203 \| GON-10 \| HD1 \| RPD3 \| RPD3L1	histone deacetylase 1	-	HPRD,BioGRID	11929879
HUS1	-	HUS1 checkpoint homolog (S. pombe)	-	HPRD,BioGRID	11077446
ING1	p24ING1c \| p33 \| p33ING1 \| p33ING1b \| p47 \| p47ING1a	inhibitor of growth family, member 1	-	HPRD,BioGRID	11682605 \|12015309
KCTD13	FKSG86 \| PDIP1 \| POLDIP1	potassium channel tetramerisation domain containing 13	C terminus of PDIP1 interacts with PCNA.	BIND	11593007
KCTD13	FKSG86 \| PDIP1 \| POLDIP1	potassium channel tetramerisation domain containing 13	-	HPRD,BioGRID	11593007
LIG1	MGC117397 \| MGC130025	ligase I, DNA, ATP-dependent	-	HPRD,BioGRID	12171929
LIG1	MGC117397 \| MGC130025	ligase I, DNA, ATP-dependent	LIG1 is a PCNA-binding protein	BIND	12171929
MCL1	BCL2L3 \| EAT \| MCL1L \| MCL1S \| MGC104264 \| MGC1839 \| TM	myeloid cell leukemia sequence 1 (BCL2-related)	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	10978339
MSH2	COCA1 \| FCC1 \| HNPCC \| HNPCC1 \| LCFS2	mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)	-	HPRD,BioGRID	8858149 \|12171929
MSH3	DUP \| MGC163306 \| MGC163308 \| MRP1	mutS homolog 3 (E. coli)	MSH3 is a PCNA-binding protein	BIND	12171929
MSH3	DUP \| MGC163306 \| MGC163308 \| MRP1	mutS homolog 3 (E. coli)	-	HPRD,BioGRID	11005803 \|11274057 \|12171929
MSH6	GTBP \| HNPCC5 \| HSAP	mutS homolog 6 (E. coli)	-	HPRD	11005803 \|12171929
MSH6	GTBP \| HNPCC5 \| HSAP	mutS homolog 6 (E. coli)	Affinity Capture-MS Affinity Capture-Western Far Western Protein-peptide	BioGRID	11005803 \|11274057 \|12171929
MSH6	GTBP \| HNPCC5 \| HSAP	mutS homolog 6 (E. coli)	MSH6 is a PCNA-binding protein	BIND	12171929
MUTYH	MGC4416 \| MYH	mutY homolog (E. coli)	-	HPRD,BioGRID	11092888
MUTYH	MGC4416 \| MYH	mutY homolog (E. coli)	hMYH is associated in vivo with proliferating cell nuclear antigen (PCNA)	BIND	11092888
MYBBP1A	FLJ37886 \| P160 \| PAP2	MYB binding protein (P160) 1a	-	HPRD,BioGRID	12171929
MYBBP1A	FLJ37886 \| P160 \| PAP2	MYB binding protein (P160) 1a	MYBBP1A is a PCNA-binding protein	BIND	12171929
NONO	NMT55 \| NRB54 \| P54 \| P54NRB	non-POU domain containing, octamer-binding	NONO is a PCNA-binding protein	BIND	12171929
PARP1	ADPRT \| ADPRT1 \| PARP \| PARP-1 \| PPOL \| pADPRT-1	poly (ADP-ribose) polymerase 1	Affinity Capture-Western	BioGRID	12930846
PCNA	MGC8367	proliferating cell nuclear antigen	Co-purification	BioGRID	9545252
PCNA	MGC8367	proliferating cell nuclear antigen	PCNA interacts with PCNA.	BIND	10858286
POLB	MGC125976	polymerase (DNA directed), beta	Mammalian DNA beta-polymerase and PCNA can form a complex both in vitro and in vivo	BIND	12063248
POLD1	CDC2 \| POLD	polymerase (DNA directed), delta 1, catalytic subunit 125kDa	POLD1 is a PCNA-binding protein	BIND	12171929
POLD1	CDC2 \| POLD	polymerase (DNA directed), delta 1, catalytic subunit 125kDa	-	HPRD,BioGRID	9563011
POLD2	-	polymerase (DNA directed), delta 2, regulatory subunit 50kDa	PCNA interacts with the small subunit of DNA polymerase delta	BIND	11986310
POLD2	-	polymerase (DNA directed), delta 2, regulatory subunit 50kDa	-	HPRD	11986310 \|12171929
POLD2	-	polymerase (DNA directed), delta 2, regulatory subunit 50kDa	-	HPRD,BioGRID	11986310
POLD3	KIAA0039 \| MGC119642 \| MGC119643 \| P66 \| P68	polymerase (DNA-directed), delta 3, accessory subunit	KIAA0039 is a PCNA-binding protein	BIND	12171929
POLD3	KIAA0039 \| MGC119642 \| MGC119643 \| P66 \| P68	polymerase (DNA-directed), delta 3, accessory subunit	-	HPRD	10219083
POLD3	KIAA0039 \| MGC119642 \| MGC119643 \| P66 \| P68	polymerase (DNA-directed), delta 3, accessory subunit	-	HPRD,BioGRID	11595739 \|12171929
POLDIP2	DKFZp586F1524 \| PDIP38 \| POLD4	polymerase (DNA-directed), delta interacting protein 2	-	HPRD,BioGRID	12522211
POLDIP2	DKFZp586F1524 \| PDIP38 \| POLD4	polymerase (DNA-directed), delta interacting protein 2	PDIP38 interacts with PCNA.	BIND	12522211
POLE	DKFZp434F222 \| FLJ21434 \| POLE1	polymerase (DNA directed), epsilon	-	HPRD,BioGRID	12171929
POLE	DKFZp434F222 \| FLJ21434 \| POLE1	polymerase (DNA directed), epsilon	POLE is a PCNA-binding protein	BIND	12171929
POLH	FLJ16395 \| FLJ21978 \| RAD30 \| RAD30A \| XP-V \| XPV	polymerase (DNA directed), eta	-	HPRD,BioGRID	11585903
POLL	BETA-N \| FLJ46002 \| POL-KAPPA	polymerase (DNA directed), lambda	-	HPRD,BioGRID	12368291
POLM	Tdt-N	polymerase (DNA directed), mu	-	HPRD	11724965
PRKDC	DNA-PKcs \| DNAPK \| DNPK1 \| HYRC \| HYRC1 \| XRCC7 \| p350	protein kinase, DNA-activated, catalytic polypeptide	-	HPRD,BioGRID	12171929
PRKDC	DNA-PKcs \| DNAPK \| DNPK1 \| HYRC \| HYRC1 \| XRCC7 \| p350	protein kinase, DNA-activated, catalytic polypeptide	PRKDC is a PCNA-binding protein	BIND	12171929
PTMA	MGC104802 \| TMSA	prothymosin, alpha	-	HPRD	11310559
RAD9A	RAD9	RAD9 homolog A (S. pombe)	-	HPRD	11994305
RFC1	A1 \| MGC51786 \| MHCBFB \| PO-GA \| RECC1 \| RFC \| RFC140	replication factor C (activator 1) 1, 145kDa	-	HPRD	8861969 \|12045192 \|12171929
RFC1	A1 \| MGC51786 \| MHCBFB \| PO-GA \| RECC1 \| RFC \| RFC140	replication factor C (activator 1) 1, 145kDa	Affinity Capture-MS Affinity Capture-Western Reconstituted Complex	BioGRID	8861969 \|8999859 \|10353443 \|12171929 \|12192049
RFC2	A1 \| MGC3665 \| RFC40	replication factor C (activator 1) 2, 40kDa	RFC2 is a PCNA-binding protein	BIND	12171929
RFC2	A1 \| MGC3665 \| RFC40	replication factor C (activator 1) 2, 40kDa	Affinity Capture-MS Reconstituted Complex	BioGRID	8093561 \|9228079 \|12171929
RFC2	A1 \| MGC3665 \| RFC40	replication factor C (activator 1) 2, 40kDa	-	HPRD	1313560 \|9228079 \|10051561 \|12171929
RFC3	MGC5276 \| RFC38	replication factor C (activator 1) 3, 38kDa	-	HPRD	10051561 \|12171929
RFC3	MGC5276 \| RFC38	replication factor C (activator 1) 3, 38kDa	RFC3 is a PCNA-binding protein	BIND	12171929
RFC3	MGC5276 \| RFC38	replication factor C (activator 1) 3, 38kDa	Affinity Capture-MS Affinity Capture-Western	BioGRID	12171929 \|12766176
RFC4	A1 \| MGC27291 \| RFC37	replication factor C (activator 1) 4, 37kDa	Affinity Capture-MS Affinity Capture-Western Reconstituted Complex	BioGRID	9228079 \|12171929
RFC4	A1 \| MGC27291 \| RFC37	replication factor C (activator 1) 4, 37kDa	-	HPRD	10051561 \|12171929
RFC5	MGC1155 \| RFC36	replication factor C (activator 1) 5, 36.5kDa	RFC5 is a PCNA-binding protein	BIND	12171929
RFC5	MGC1155 \| RFC36	replication factor C (activator 1) 5, 36.5kDa	Affinity Capture-MS Reconstituted Complex	BioGRID	8999859 \|9228079 \|12171929
RFC5	MGC1155 \| RFC36	replication factor C (activator 1) 5, 36.5kDa	-	HPRD	8999859 \|9751713 \|12171929 \|12237462
RPA1	HSSB \| REPA1 \| RF-A \| RP-A \| RPA70	replication protein A1, 70kDa	-	HPRD,BioGRID	12171929
RUVBL2	CGI-46 \| ECP51 \| INO80J \| REPTIN \| RVB2 \| TIH2 \| TIP48 \| TIP49B	RuvB-like 2 (E. coli)	Affinity Capture-MS	BioGRID	12171929
SUB1	MGC102747 \| P15 \| PC4 \| p14	SUB1 homolog (S. cerevisiae)	Two-hybrid	BioGRID	11313979
TCOF1	MFD1 \| treacle	Treacher Collins-Franceschetti syndrome 1	TCOF1 is a PCNA-binding protein	BIND	12171929
UNG	DGU \| DKFZp781L1143 \| HIGM4 \| UDG \| UNG1 \| UNG15 \| UNG2	uracil-DNA glycosylase	UNG is a PCNA-binding protein	BIND	12171929
WRN	DKFZp686C2056 \| RECQ3 \| RECQL2 \| RECQL3	Werner syndrome	-	HPRD,BioGRID	10871373 \|12633936
XRCC1	RCC	X-ray repair complementing defective repair in Chinese hamster cells 1	Affinity Capture-Western Co-localization FRET Reconstituted Complex	BioGRID	15107487
XRCC5	FLJ39089 \| KARP-1 \| KARP1 \| KU80 \| KUB2 \| Ku86 \| NFIV	X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)	-	HPRD,BioGRID	12393188
XRCC6	CTC75 \| CTCBF \| G22P1 \| KU70 \| ML8 \| TLAA	X-ray repair complementing defective repair in Chinese hamster cells 6	-	HPRD,BioGRID	11239001 \|12171929
YBX1	BP-8 \| CSDA2 \| CSDB \| DBPB \| MDR-NF1 \| MGC104858 \| MGC110976 \| MGC117250 \| NSEP-1 \| NSEP1 \| YB-1 \| YB1	Y box binding protein 1	-	HPRD,BioGRID	9927044

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG DNA REPLICATION	36	21	All SZGR 2.0 genes in this pathway
KEGG BASE EXCISION REPAIR	35	22	All SZGR 2.0 genes in this pathway
KEGG NUCLEOTIDE EXCISION REPAIR	44	25	All SZGR 2.0 genes in this pathway
KEGG MISMATCH REPAIR	23	14	All SZGR 2.0 genes in this pathway
KEGG CELL CYCLE	128	84	All SZGR 2.0 genes in this pathway
BIOCARTA P53 PATHWAY	16	13	All SZGR 2.0 genes in this pathway
PID P53 DOWNSTREAM PATHWAY	137	94	All SZGR 2.0 genes in this pathway
PID ERA GENOMIC PATHWAY	65	37	All SZGR 2.0 genes in this pathway
PID BARD1 PATHWAY	29	19	All SZGR 2.0 genes in this pathway
REACTOME BASE EXCISION REPAIR	19	13	All SZGR 2.0 genes in this pathway
REACTOME G0 AND EARLY G1	25	13	All SZGR 2.0 genes in this pathway
REACTOME RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY	17	11	All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE	421	253	All SZGR 2.0 genes in this pathway
REACTOME PROCESSIVE SYNTHESIS ON THE LAGGING STRAND	15	10	All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE MITOTIC	325	185	All SZGR 2.0 genes in this pathway
REACTOME TRANSCRIPTION COUPLED NER TC NER	45	24	All SZGR 2.0 genes in this pathway
REACTOME G1 S TRANSITION	112	63	All SZGR 2.0 genes in this pathway
REACTOME POL SWITCHING	13	9	All SZGR 2.0 genes in this pathway
REACTOME NUCLEOTIDE EXCISION REPAIR	51	27	All SZGR 2.0 genes in this pathway
REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER	14	11	All SZGR 2.0 genes in this pathway
REACTOME SYNTHESIS OF DNA	92	53	All SZGR 2.0 genes in this pathway
REACTOME MITOTIC G1 G1 S PHASES	137	79	All SZGR 2.0 genes in this pathway
REACTOME DNA REPAIR	112	59	All SZGR 2.0 genes in this pathway
REACTOME CHROMOSOME MAINTENANCE	122	80	All SZGR 2.0 genes in this pathway
REACTOME GLOBAL GENOMIC NER GG NER	35	20	All SZGR 2.0 genes in this pathway
REACTOME LAGGING STRAND SYNTHESIS	19	12	All SZGR 2.0 genes in this pathway
REACTOME DNA REPLICATION	192	110	All SZGR 2.0 genes in this pathway
REACTOME E2F MEDIATED REGULATION OF DNA REPLICATION	35	17	All SZGR 2.0 genes in this pathway
REACTOME G1 S SPECIFIC TRANSCRIPTION	19	9	All SZGR 2.0 genes in this pathway
REACTOME TELOMERE MAINTENANCE	75	57	All SZGR 2.0 genes in this pathway
REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND	10	8	All SZGR 2.0 genes in this pathway
REACTOME EXTENSION OF TELOMERES	27	17	All SZGR 2.0 genes in this pathway
REACTOME S PHASE	109	66	All SZGR 2.0 genes in this pathway
REACTOME DNA STRAND ELONGATION	30	18	All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA UP	783	507	All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA UP	294	178	All SZGR 2.0 genes in this pathway
BORCZUK MALIGNANT MESOTHELIOMA UP	305	185	All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER UP	404	246	All SZGR 2.0 genes in this pathway
RHEIN ALL GLUCOCORTICOID THERAPY DN	362	238	All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 24HR UP	557	331	All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP	1278	748	All SZGR 2.0 genes in this pathway
GRAHAM NORMAL QUIESCENT VS NORMAL DIVIDING DN	87	49	All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN	1375	806	All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED UP	633	376	All SZGR 2.0 genes in this pathway
LAU APOPTOSIS CDKN2A UP	55	40	All SZGR 2.0 genes in this pathway
CHIARADONNA NEOPLASTIC TRANSFORMATION KRAS UP	126	72	All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 3 UP	329	196	All SZGR 2.0 genes in this pathway
MARKEY RB1 CHRONIC LOF UP	115	78	All SZGR 2.0 genes in this pathway
MARKEY RB1 ACUTE LOF DN	228	137	All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA UP	536	340	All SZGR 2.0 genes in this pathway
JOHANSSON GLIOMAGENESIS BY PDGFB UP	58	44	All SZGR 2.0 genes in this pathway
OLSSON E2F3 TARGETS DN	49	33	All SZGR 2.0 genes in this pathway
SCHAVOLT TARGETS OF TP53 AND TP63	16	12	All SZGR 2.0 genes in this pathway
MATTIOLI MGUS VS PCL	116	62	All SZGR 2.0 genes in this pathway
ROSTY CERVICAL CANCER PROLIFERATION CLUSTER	140	73	All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER	747	453	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 UP	309	199	All SZGR 2.0 genes in this pathway
AMUNDSON GENOTOXIC SIGNATURE	105	68	All SZGR 2.0 genes in this pathway
MOHANKUMAR TLX1 TARGETS UP	414	287	All SZGR 2.0 genes in this pathway
TSAI RESPONSE TO IONIZING RADIATION	149	101	All SZGR 2.0 genes in this pathway
CALVET IRINOTECAN SENSITIVE VS REVERTED DN	5	5	All SZGR 2.0 genes in this pathway
PUJANA XPRSS INT NETWORK	168	103	All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK	1652	1023	All SZGR 2.0 genes in this pathway
PUJANA BRCA2 PCC NETWORK	423	265	All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK	1442	892	All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK	779	480	All SZGR 2.0 genes in this pathway
PUJANA BRCA CENTERED NETWORK	117	72	All SZGR 2.0 genes in this pathway
KAUFFMANN MELANOMA RELAPSE UP	61	25	All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS	957	597	All SZGR 2.0 genes in this pathway
SCIAN INVERSED TARGETS OF TP53 AND TP73 UP	11	9	All SZGR 2.0 genes in this pathway
CAFFAREL RESPONSE TO THC 24HR 5 UP	34	23	All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS	988	594	All SZGR 2.0 genes in this pathway
BENPORATH MYC MAX TARGETS	775	494	All SZGR 2.0 genes in this pathway
BENPORATH CYCLING GENES	648	385	All SZGR 2.0 genes in this pathway
BENPORATH PROLIFERATION	147	80	All SZGR 2.0 genes in this pathway
SAKAI TUMOR INFILTRATING MONOCYTES DN	81	51	All SZGR 2.0 genes in this pathway
SUNG METASTASIS STROMA DN	54	34	All SZGR 2.0 genes in this pathway
MORI IMMATURE B LYMPHOCYTE DN	90	55	All SZGR 2.0 genes in this pathway
KAUFFMANN DNA REPAIR GENES	230	137	All SZGR 2.0 genes in this pathway
KAUFFMANN DNA REPLICATION GENES	147	87	All SZGR 2.0 genes in this pathway
BASSO B LYMPHOCYTE NETWORK	143	96	All SZGR 2.0 genes in this pathway
KANNAN TP53 TARGETS UP	58	40	All SZGR 2.0 genes in this pathway
LIN APC TARGETS	77	55	All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST DN	309	206	All SZGR 2.0 genes in this pathway
SMITH TERT TARGETS DN	87	69	All SZGR 2.0 genes in this pathway
REN BOUND BY E2F	61	40	All SZGR 2.0 genes in this pathway
SASAKI ADULT T CELL LEUKEMIA	176	122	All SZGR 2.0 genes in this pathway
YU MYC TARGETS UP	42	26	All SZGR 2.0 genes in this pathway
LEI MYB TARGETS	318	215	All SZGR 2.0 genes in this pathway
LI WILMS TUMOR VS FETAL KIDNEY 1 DN	163	115	All SZGR 2.0 genes in this pathway
FERRANDO T ALL WITH MLL ENL FUSION DN	87	57	All SZGR 2.0 genes in this pathway
HADDAD B LYMPHOCYTE PROGENITOR	293	193	All SZGR 2.0 genes in this pathway
VERNELL RETINOBLASTOMA PATHWAY UP	70	47	All SZGR 2.0 genes in this pathway
YAGI AML FAB MARKERS	191	131	All SZGR 2.0 genes in this pathway
IGLESIAS E2F TARGETS UP	151	103	All SZGR 2.0 genes in this pathway
KAMMINGA EZH2 TARGETS	41	26	All SZGR 2.0 genes in this pathway
ZAMORA NOS2 TARGETS UP	69	41	All SZGR 2.0 genes in this pathway
HEDENFALK BREAST CANCER HEREDITARY VS SPORADIC	50	32	All SZGR 2.0 genes in this pathway
LEE CALORIE RESTRICTION NEOCORTEX UP	83	66	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN	1237	837	All SZGR 2.0 genes in this pathway
JIANG VHL TARGETS	138	91	All SZGR 2.0 genes in this pathway
MAHAJAN RESPONSE TO IL1A DN	76	57	All SZGR 2.0 genes in this pathway
INGA TP53 TARGETS	17	13	All SZGR 2.0 genes in this pathway
RHODES UNDIFFERENTIATED CANCER	69	44	All SZGR 2.0 genes in this pathway
MACLACHLAN BRCA1 TARGETS UP	21	16	All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 3	101	64	All SZGR 2.0 genes in this pathway
SESTO RESPONSE TO UV C0	107	72	All SZGR 2.0 genes in this pathway
MODY HIPPOCAMPUS PRENATAL	42	33	All SZGR 2.0 genes in this pathway
SONG TARGETS OF IE86 CMV PROTEIN	60	42	All SZGR 2.0 genes in this pathway
HEDENFALK BREAST CANCER BRCA1 VS BRCA2	163	113	All SZGR 2.0 genes in this pathway
KALMA E2F1 TARGETS	11	7	All SZGR 2.0 genes in this pathway
LY AGING OLD DN	56	35	All SZGR 2.0 genes in this pathway
SIMBULAN PARP1 TARGETS DN	17	10	All SZGR 2.0 genes in this pathway
MARIADASON RESPONSE TO BUTYRATE SULINDAC 6	52	32	All SZGR 2.0 genes in this pathway
MARTINEZ RESPONSE TO TRABECTEDIN DN	271	175	All SZGR 2.0 genes in this pathway
BILD E2F3 ONCOGENIC SIGNATURE	246	153	All SZGR 2.0 genes in this pathway
ZHONG SECRETOME OF LUNG CANCER AND ENDOTHELIUM	66	47	All SZGR 2.0 genes in this pathway
HILLION HMGA1 TARGETS	90	71	All SZGR 2.0 genes in this pathway
HILLION HMGA1B TARGETS	92	68	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 COMMON UP	77	47	All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS RESPONSIVE TO ESTROGEN DN	41	26	All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE BY 4NQO OR UV	63	44	All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE DN	195	135	All SZGR 2.0 genes in this pathway
SARRIO EPITHELIAL MESENCHYMAL TRANSITION UP	180	114	All SZGR 2.0 genes in this pathway
WHITEFORD PEDIATRIC CANCER MARKERS	116	63	All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP	871	505	All SZGR 2.0 genes in this pathway
GRADE COLON AND RECTAL CANCER UP	285	167	All SZGR 2.0 genes in this pathway
LABBE WNT3A TARGETS UP	112	71	All SZGR 2.0 genes in this pathway
BHATI G2M ARREST BY 2METHOXYESTRADIOL UP	125	68	All SZGR 2.0 genes in this pathway
BRUECKNER TARGETS OF MIRLET7A3 UP	111	69	All SZGR 2.0 genes in this pathway
BLUM RESPONSE TO SALIRASIB DN	342	220	All SZGR 2.0 genes in this pathway
MUELLER PLURINET	299	189	All SZGR 2.0 genes in this pathway
WANG TUMOR INVASIVENESS UP	374	247	All SZGR 2.0 genes in this pathway
LEE LIVER CANCER SURVIVAL DN	175	103	All SZGR 2.0 genes in this pathway
GOLDRATH ANTIGEN RESPONSE	346	192	All SZGR 2.0 genes in this pathway
MARSHALL VIRAL INFECTION RESPONSE DN	29	21	All SZGR 2.0 genes in this pathway
CHANG CYCLING GENES	148	83	All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER POOR SURVIVAL A6	456	285	All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK	1210	725	All SZGR 2.0 genes in this pathway
CROONQUIST IL6 DEPRIVATION DN	98	69	All SZGR 2.0 genes in this pathway
CROONQUIST NRAS SIGNALING DN	72	47	All SZGR 2.0 genes in this pathway
ISHIDA E2F TARGETS	53	27	All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS UNANNOTATED DN	193	112	All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER LATE RECURRENCE UP	62	42	All SZGR 2.0 genes in this pathway
STEIN ESR1 TARGETS	85	55	All SZGR 2.0 genes in this pathway
SAKAI CHRONIC HEPATITIS VS LIVER CANCER UP	83	63	All SZGR 2.0 genes in this pathway
KOBAYASHI EGFR SIGNALING 24HR DN	251	151	All SZGR 2.0 genes in this pathway
WINNEPENNINCKX MELANOMA METASTASIS UP	162	86	All SZGR 2.0 genes in this pathway
KYNG WERNER SYNDROM AND NORMAL AGING UP	93	62	All SZGR 2.0 genes in this pathway
DANG MYC TARGETS UP	143	100	All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC	1103	714	All SZGR 2.0 genes in this pathway
WONG EMBRYONIC STEM CELL CORE	335	193	All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 10	69	38	All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE LITERATURE	44	25	All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE G1 S	147	76	All SZGR 2.0 genes in this pathway
KARLSSON TGFB1 TARGETS DN	207	139	All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE DN	841	431	All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS SENESCENT	572	352	All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 6HR UP	229	149	All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR UP	324	193	All SZGR 2.0 genes in this pathway
FIGUEROA AML METHYLATION CLUSTER 1 DN	48	30	All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN	918	550	All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS DN	553	343	All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE VIA P38 COMPLETE	227	151	All SZGR 2.0 genes in this pathway
ABRAMSON INTERACT WITH AIRE	45	33	All SZGR 2.0 genes in this pathway
WARTERS IR RESPONSE 5GY	47	23	All SZGR 2.0 genes in this pathway
ZHOU CELL CYCLE GENES IN IR RESPONSE 24HR	128	73	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-217	273	279	m8	hsa-miR-217	UACUGCAUCAGGAACUGAUUGGAU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: PCNA