Gene Page: PDC
Summary ?
| GeneID | 5132 |
| Symbol | PDC |
| Synonyms | MEKA|PHD|PhLOP|PhLP |
| Description | phosducin |
| Reference | MIM:171490|HGNC:HGNC:8759|Ensembl:ENSG00000116703|HPRD:01373|Vega:OTTHUMG00000035575 |
| Gene type | protein-coding |
| Map location | 1q25.2 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| NAPA | 0.88 | 0.86 |
| GBA | 0.88 | 0.87 |
| ALDOA | 0.87 | 0.88 |
| C16orf5 | 0.87 | 0.88 |
| THY1 | 0.86 | 0.85 |
| C6orf136 | 0.85 | 0.85 |
| RHBDD2 | 0.85 | 0.86 |
| ISCU | 0.85 | 0.88 |
| KCNAB2 | 0.85 | 0.82 |
| NCKIPSD | 0.85 | 0.87 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| FAM36A | -0.49 | -0.48 |
| EIF5B | -0.47 | -0.55 |
| AC005921.3 | -0.47 | -0.62 |
| RP9P | -0.45 | -0.55 |
| RBMX2 | -0.45 | -0.50 |
| FAM159B | -0.42 | -0.64 |
| GTF3C6 | -0.40 | -0.41 |
| AC109829.1 | -0.40 | -0.40 |
| AIM2 | -0.40 | -0.39 |
| AC011475.1 | -0.40 | -0.44 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG OLFACTORY TRANSDUCTION | 389 | 85 | All SZGR 2.0 genes in this pathway |
| SENGUPTA NASOPHARYNGEAL CARCINOMA WITH LMP1 UP | 408 | 247 | All SZGR 2.0 genes in this pathway |
| SHEPARD BMYB MORPHOLINO UP | 205 | 126 | All SZGR 2.0 genes in this pathway |
| BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS | 882 | 572 | All SZGR 2.0 genes in this pathway |
| IVANOVA HEMATOPOIESIS STEM CELL | 254 | 164 | All SZGR 2.0 genes in this pathway |