Gene Page: EIF3L

Summary ?
GeneID51386
SymbolEIF3L
SynonymsEIF3EIP|EIF3S11|EIF3S6IP|HSPC021|HSPC025|MSTP005
Descriptioneukaryotic translation initiation factor 3 subunit L
ReferenceHGNC:HGNC:18138|Ensembl:ENSG00000100129|HPRD:10932|Vega:OTTHUMG00000150671
Gene typeprotein-coding
Map location22q
Pascal p-value0.691
Sherlock p-value0.23
Fetal beta1.702
DMG1 (# studies)
eGeneCerebellar Hemisphere
Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg158533742238245447EIF3L1.89E-10-0.0395.4E-7DMG:Jaffe_2016

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs760521chr2237247850EIF3L513860.18cis
rs10894158chr11129736156EIF3L513860.18trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI15231747 |17353931 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006412translationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0001650fibrillar centerIEA-
GO:0005634nucleusIDA18029348 
GO:0005654nucleoplasmIEA-
GO:0005730nucleolusIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL DN 634384All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA DN 526357All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 1 UP 12171All SZGR 2.0 genes in this pathway
RICKMAN TUMOR DIFFERENTIATED WELL VS POORLY UP 236139All SZGR 2.0 genes in this pathway
STARK PREFRONTAL CORTEX 22Q11 DELETION DN 517309All SZGR 2.0 genes in this pathway
HOWLIN CITED1 TARGETS 1 UP 3525All SZGR 2.0 genes in this pathway
GAVIN FOXP3 TARGETS CLUSTER T7 9863All SZGR 2.0 genes in this pathway
KYNG ENVIRONMENTAL STRESS RESPONSE NOT BY 4NQO IN OLD 1310All SZGR 2.0 genes in this pathway
KYNG ENVIRONMENTAL STRESS RESPONSE NOT BY GAMMA IN OLD 3119All SZGR 2.0 genes in this pathway
KYNG ENVIRONMENTAL STRESS RESPONSE NOT BY UV IN OLD 2518All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE DN 195135All SZGR 2.0 genes in this pathway
KYNG ENVIRONMENTAL STRESS RESPONSE UP 5641All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR DN 546362All SZGR 2.0 genes in this pathway
MOOTHA PGC 420269All SZGR 2.0 genes in this pathway
FLOTHO PEDIATRIC ALL THERAPY RESPONSE UP 5333All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES UP 605377All SZGR 2.0 genes in this pathway
KYNG NORMAL AGING UP 1911All SZGR 2.0 genes in this pathway
KYNG WERNER SYNDROM UP 2010All SZGR 2.0 genes in this pathway
WONG EMBRYONIC STEM CELL CORE 335193All SZGR 2.0 genes in this pathway
BILANGES SERUM AND RAPAMYCIN SENSITIVE GENES 6835All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS DN 553343All SZGR 2.0 genes in this pathway
DELACROIX RAR BOUND ES 462273All SZGR 2.0 genes in this pathway
HOLLEMAN ASPARAGINASE RESISTANCE B ALL UP 2615All SZGR 2.0 genes in this pathway