Gene Page: ANAPC5
Summary ?
| GeneID | 51433 |
| Symbol | ANAPC5 |
| Synonyms | APC5 |
| Description | anaphase promoting complex subunit 5 |
| Reference | MIM:606948|HGNC:HGNC:15713|Ensembl:ENSG00000089053|HPRD:10453|Vega:OTTHUMG00000169157 |
| Gene type | protein-coding |
| Map location | 12q24.31 |
| Pascal p-value | 0.044 |
| Sherlock p-value | 0.191 |
| Fetal beta | 0.596 |
| eGene | Cerebellum Meta |
| Support | CompositeSet |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DNM:Fromer_2014 | Whole Exome Sequencing analysis | This study reported a WES study of 623 schizophrenia trios, reporting DNMs using genomic DNA. |
Section I. Genetics and epigenetics annotation
DNM table
| Gene | Chromosome | Position | Ref | Alt | Transcript | AA change | Mutation type | Sift | CG46 | Trait | Study |
|---|---|---|---|---|---|---|---|---|---|---|---|
| ANAPC5 | chr12 | 121746313 | A | G | NM_001137559 NM_016237 | . . | silent silent | Schizophrenia | DNM:Fromer_2014 | ||
| ANAPC5 | chr12 | 121756326 | T | C | NM_001137559 NM_016237 | p.463K>E p.575K>E | missense missense | Schizophrenia | DNM:Fromer_2014 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| ANAPC1 | APC1 | MCPR | TSG24 | anaphase promoting complex subunit 1 | - | HPRD,BioGRID | 10922056 |
| ANAPC10 | APC10 | DKFZp564L0562 | DOC1 | anaphase promoting complex subunit 10 | - | HPRD,BioGRID | 10922056 |
| ANAPC11 | APC11 | Apc11p | HSPC214 | MGC882 | anaphase promoting complex subunit 11 | - | HPRD,BioGRID | 10922056 |
| ANAPC2 | APC2 | RP11-350O14.5 | anaphase promoting complex subunit 2 | - | HPRD,BioGRID | 10922056 |
| ANAPC4 | APC4 | anaphase promoting complex subunit 4 | - | HPRD,BioGRID | 10922056 |
| ANAPC7 | APC7 | anaphase promoting complex subunit 7 | - | HPRD | 10922056 |
| ANAPC7 | APC7 | anaphase promoting complex subunit 7 | Reconstituted Complex | BioGRID | 12956947 |
| APC2 | APCL | adenomatosis polyposis coli 2 | Affinity Capture-Western | BioGRID | 12956947 |
| CDC16 | APC6 | cell division cycle 16 homolog (S. cerevisiae) | - | HPRD,BioGRID | 10922056 |
| CDC20 | CDC20A | MGC102824 | bA276H19.3 | p55CDC | cell division cycle 20 homolog (S. cerevisiae) | Reconstituted Complex | BioGRID | 12956947 |
| CDC23 | APC8 | cell division cycle 23 homolog (S. cerevisiae) | - | HPRD,BioGRID | 10922056 |
| CDC27 | APC3 | CDC27Hs | D0S1430E | D17S978E | HNUC | cell division cycle 27 homolog (S. cerevisiae) | - | HPRD,BioGRID | 10922056 |
| FZR1 | CDC20C | CDH1 | FZR | FZR2 | HCDH | HCDH1 | KIAA1242 | fizzy/cell division cycle 20 related 1 (Drosophila) | Reconstituted Complex | BioGRID | 12956947 |
| PABPC1 | PAB1 | PABP | PABP1 | PABPC2 | PABPL1 | poly(A) binding protein, cytoplasmic 1 | - | HPRD,BioGRID | 15082755 |
| ZBTB16 | PLZF | ZNF145 | zinc finger and BTB domain containing 16 | Two-hybrid | BioGRID | 16169070 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG CELL CYCLE | 128 | 84 | All SZGR 2.0 genes in this pathway |
| KEGG OOCYTE MEIOSIS | 114 | 79 | All SZGR 2.0 genes in this pathway |
| KEGG UBIQUITIN MEDIATED PROTEOLYSIS | 138 | 98 | All SZGR 2.0 genes in this pathway |
| KEGG PROGESTERONE MEDIATED OOCYTE MATURATION | 86 | 59 | All SZGR 2.0 genes in this pathway |
| REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS | 24 | 12 | All SZGR 2.0 genes in this pathway |
| REACTOME CELL CYCLE | 421 | 253 | All SZGR 2.0 genes in this pathway |
| REACTOME CELL CYCLE MITOTIC | 325 | 185 | All SZGR 2.0 genes in this pathway |
| REACTOME CELL CYCLE CHECKPOINTS | 124 | 70 | All SZGR 2.0 genes in this pathway |
| REACTOME REGULATION OF MITOTIC CELL CYCLE | 85 | 46 | All SZGR 2.0 genes in this pathway |
| REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 | 72 | 38 | All SZGR 2.0 genes in this pathway |
| REACTOME APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS | 73 | 40 | All SZGR 2.0 genes in this pathway |
| REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C | 64 | 34 | All SZGR 2.0 genes in this pathway |
| REACTOME APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B | 26 | 10 | All SZGR 2.0 genes in this pathway |
| REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE | 22 | 9 | All SZGR 2.0 genes in this pathway |
| REACTOME IMMUNE SYSTEM | 933 | 616 | All SZGR 2.0 genes in this pathway |
| REACTOME PHOSPHORYLATION OF THE APC C | 23 | 10 | All SZGR 2.0 genes in this pathway |
| REACTOME ADAPTIVE IMMUNE SYSTEM | 539 | 350 | All SZGR 2.0 genes in this pathway |
| REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION | 251 | 156 | All SZGR 2.0 genes in this pathway |
| REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | 212 | 129 | All SZGR 2.0 genes in this pathway |
| REACTOME APC CDC20 MEDIATED DEGRADATION OF NEK2A | 28 | 12 | All SZGR 2.0 genes in this pathway |
| ONKEN UVEAL MELANOMA DN | 526 | 357 | All SZGR 2.0 genes in this pathway |
| PRAMOONJAGO SOX4 TARGETS DN | 51 | 35 | All SZGR 2.0 genes in this pathway |
| THUM SYSTOLIC HEART FAILURE UP | 423 | 283 | All SZGR 2.0 genes in this pathway |
| DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP | 1382 | 904 | All SZGR 2.0 genes in this pathway |
| GINESTIER BREAST CANCER ZNF217 AMPLIFIED UP | 78 | 48 | All SZGR 2.0 genes in this pathway |
| OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL DN | 275 | 168 | All SZGR 2.0 genes in this pathway |
| UDAYAKUMAR MED1 TARGETS UP | 135 | 82 | All SZGR 2.0 genes in this pathway |
| SENESE HDAC1 TARGETS UP | 457 | 269 | All SZGR 2.0 genes in this pathway |
| DODD NASOPHARYNGEAL CARCINOMA DN | 1375 | 806 | All SZGR 2.0 genes in this pathway |
| PROVENZANI METASTASIS UP | 194 | 112 | All SZGR 2.0 genes in this pathway |
| MARKEY RB1 CHRONIC LOF UP | 115 | 78 | All SZGR 2.0 genes in this pathway |
| MARKEY RB1 ACUTE LOF DN | 228 | 137 | All SZGR 2.0 genes in this pathway |
| WAESCH ANAPHASE PROMOTING COMPLEX | 12 | 7 | All SZGR 2.0 genes in this pathway |
| MARTORIATI MDM4 TARGETS FETAL LIVER DN | 514 | 319 | All SZGR 2.0 genes in this pathway |
| MOHANKUMAR TLX1 TARGETS UP | 414 | 287 | All SZGR 2.0 genes in this pathway |
| PUJANA BRCA1 PCC NETWORK | 1652 | 1023 | All SZGR 2.0 genes in this pathway |
| PUJANA CHEK2 PCC NETWORK | 779 | 480 | All SZGR 2.0 genes in this pathway |
| WEI MYCN TARGETS WITH E BOX | 795 | 478 | All SZGR 2.0 genes in this pathway |
| MORI LARGE PRE BII LYMPHOCYTE UP | 86 | 49 | All SZGR 2.0 genes in this pathway |
| HADDAD B LYMPHOCYTE PROGENITOR | 293 | 193 | All SZGR 2.0 genes in this pathway |
| HASLINGER B CLL WITH CHROMOSOME 12 TRISOMY | 24 | 12 | All SZGR 2.0 genes in this pathway |
| IVANOVA HEMATOPOIESIS LATE PROGENITOR | 544 | 307 | All SZGR 2.0 genes in this pathway |
| PAL PRMT5 TARGETS UP | 203 | 135 | All SZGR 2.0 genes in this pathway |
| KRIGE RESPONSE TO TOSEDOSTAT 6HR DN | 911 | 527 | All SZGR 2.0 genes in this pathway |
| KRIGE RESPONSE TO TOSEDOSTAT 24HR DN | 1011 | 592 | All SZGR 2.0 genes in this pathway |
| MARSON BOUND BY FOXP3 UNSTIMULATED | 1229 | 713 | All SZGR 2.0 genes in this pathway |
| ZHANG BREAST CANCER PROGENITORS DN | 145 | 93 | All SZGR 2.0 genes in this pathway |
| GRADE COLON CANCER UP | 871 | 505 | All SZGR 2.0 genes in this pathway |
| GRADE COLON VS RECTAL CANCER DN | 56 | 36 | All SZGR 2.0 genes in this pathway |
| HAN SATB1 TARGETS UP | 395 | 249 | All SZGR 2.0 genes in this pathway |
| FOURNIER ACINAR DEVELOPMENT LATE 2 | 277 | 172 | All SZGR 2.0 genes in this pathway |
| KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP | 756 | 494 | All SZGR 2.0 genes in this pathway |
| KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP | 682 | 440 | All SZGR 2.0 genes in this pathway |
| JOHNSTONE PARVB TARGETS 3 UP | 430 | 288 | All SZGR 2.0 genes in this pathway |
| FEVR CTNNB1 TARGETS DN | 553 | 343 | All SZGR 2.0 genes in this pathway |
| RAO BOUND BY SALL4 ISOFORM B | 517 | 302 | All SZGR 2.0 genes in this pathway |