Gene Page: ZCCHC17
Summary ?
| GeneID | 51538 |
| Symbol | ZCCHC17 |
| Synonyms | HSPC251|PS1D|pNO40 |
| Description | zinc finger CCHC-type containing 17 |
| Reference | HGNC:HGNC:30246|Ensembl:ENSG00000121766|HPRD:15189|Vega:OTTHUMG00000003791 |
| Gene type | protein-coding |
| Map location | 1p35.2 |
| Pascal p-value | 2.785E-5 |
| Sherlock p-value | 0.852 |
| eGene | Putamen basal ganglia Myers' cis & trans Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg17748167 | 1 | 31769917 | ZCCHC17;SNRNP40 | 4.61E-5 | -0.214 | 0.021 | DMG:Wockner_2014 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs2809658 | chr1 | 43050395 | ZCCHC17 | 51538 | 0.12 | trans | ||
| rs2297681 | 1 | 32155929 | ZCCHC17 | ENSG00000121766.10 | 2.23907E-6 | 0.01 | 386087 | gtex_brain_putamen_basal |
| rs10914467 | 1 | 32156722 | ZCCHC17 | ENSG00000121766.10 | 1.68689E-6 | 0.01 | 386880 | gtex_brain_putamen_basal |
| rs2297676 | 1 | 32157531 | ZCCHC17 | ENSG00000121766.10 | 4.80133E-7 | 0.01 | 387689 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| LASTOWSKA NEUROBLASTOMA COPY NUMBER DN | 800 | 473 | All SZGR 2.0 genes in this pathway |
| PATIL LIVER CANCER | 747 | 453 | All SZGR 2.0 genes in this pathway |
| LIAO METASTASIS | 539 | 324 | All SZGR 2.0 genes in this pathway |
| MCCABE BOUND BY HOXC6 | 469 | 239 | All SZGR 2.0 genes in this pathway |
| ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP | 863 | 514 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE LATE | 1137 | 655 | All SZGR 2.0 genes in this pathway |
| PURBEY TARGETS OF CTBP1 NOT SATB1 DN | 448 | 282 | All SZGR 2.0 genes in this pathway |