Summary ?
GeneID5162
SymbolPDHB
SynonymsPDHBD|PDHE1-B|PHE1B
Descriptionpyruvate dehydrogenase (lipoamide) beta
ReferenceMIM:179060|HGNC:HGNC:8808|Ensembl:ENSG00000168291|HPRD:01530|Vega:OTTHUMG00000159157
Gene typeprotein-coding
Map location3p21.1-p14.2
Pascal p-value0.012
Sherlock p-value0.062
eGeneAnterior cingulate cortex BA24
Caudate basal ganglia
Cerebellar Hemisphere
Cerebellum
Cortex
Meta
SupportG2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL
G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS
G2Cdb.human_clathrin
G2Cdb.human_mitochondria
G2Cdb.human_Synaptosome
G2Cdb.human_TAP-PSD-95-CORE
G2Cdb.humanPSD
G2Cdb.humanPSP
CompositeSet

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs9857570358280690PDHBENSG00000168291.81.751E-60138894gtex_brain_ba24
rs6445967358282576PDHBENSG00000168291.81.751E-60137008gtex_brain_ba24
rs9846885358285789PDHBENSG00000168291.81.751E-60133795gtex_brain_ba24
rs9847151358285808PDHBENSG00000168291.81.751E-60133776gtex_brain_ba24
rs13325699358286870PDHBENSG00000168291.81.751E-60132714gtex_brain_ba24
rs7640866358288362PDHBENSG00000168291.81.751E-60131222gtex_brain_ba24
rs62259323358291047PDHBENSG00000168291.81.549E-60128537gtex_brain_ba24
rs62259324358291107PDHBENSG00000168291.81.545E-60128477gtex_brain_ba24
rs9867776358295401PDHBENSG00000168291.81.34E-60124183gtex_brain_ba24
rs4336086358297390PDHBENSG00000168291.81.288E-60122194gtex_brain_ba24
rs201546547358297410PDHBENSG00000168291.81.729E-60122174gtex_brain_ba24
rs35955376358297779PDHBENSG00000168291.81.284E-60121805gtex_brain_ba24
rs2292673358301901PDHBENSG00000168291.81.216E-60117683gtex_brain_ba24
rs2292674358302404PDHBENSG00000168291.82.303E-60117180gtex_brain_ba24
rs14927358305033PDHBENSG00000168291.88.036E-70114551gtex_brain_ba24
rs12688358305079PDHBENSG00000168291.81.085E-60114505gtex_brain_ba24
rs12630913358306070PDHBENSG00000168291.81.097E-60113514gtex_brain_ba24
rs12636243358306216PDHBENSG00000168291.81.208E-60113368gtex_brain_ba24
rs12633655358306321PDHBENSG00000168291.81.872E-60113263gtex_brain_ba24
rs11712758358306579PDHBENSG00000168291.81.085E-60113005gtex_brain_ba24
rs11713627358306946PDHBENSG00000168291.81.085E-60112638gtex_brain_ba24
rs6777105358307644PDHBENSG00000168291.81.085E-60111940gtex_brain_ba24
rs1913715358308214PDHBENSG00000168291.81.085E-60111370gtex_brain_ba24
rs1913716358308331PDHBENSG00000168291.81.085E-60111253gtex_brain_ba24
rs6791748358308519PDHBENSG00000168291.81.085E-60111065gtex_brain_ba24
rs1055973358308960PDHBENSG00000168291.88.036E-70110624gtex_brain_ba24
rs34611088358312923PDHBENSG00000168291.81.085E-60106661gtex_brain_ba24
rs13059916358316364PDHBENSG00000168291.81.085E-60103220gtex_brain_ba24
rs11714574358380465PDHBENSG00000168291.82.396E-7039119gtex_brain_ba24

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
ZNF1340.950.96
ZKSCAN50.940.95
VEZT0.940.95
TSR10.940.94
HMG20A0.940.95
THRAP30.940.94
ZMYM40.930.95
OSBPL110.930.94
CAPN70.930.94
DIS30.930.95
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.31-0.82-0.90
MT-CO2-0.82-0.90
AF347015.27-0.80-0.88
FXYD1-0.79-0.88
AF347015.33-0.79-0.86
AF347015.8-0.78-0.89
MT-CYB-0.78-0.87
IFI27-0.77-0.87
AF347015.15-0.76-0.86
HIGD1B-0.75-0.86

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG GLYCOLYSIS GLUCONEOGENESIS 6241All SZGR 2.0 genes in this pathway
KEGG CITRATE CYCLE TCA CYCLE 3223All SZGR 2.0 genes in this pathway
KEGG VALINE LEUCINE AND ISOLEUCINE BIOSYNTHESIS 118All SZGR 2.0 genes in this pathway
KEGG PYRUVATE METABOLISM 4026All SZGR 2.0 genes in this pathway
KEGG BUTANOATE METABOLISM 3420All SZGR 2.0 genes in this pathway
REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE 4832All SZGR 2.0 genes in this pathway
REACTOME TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT 14185All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX 139All SZGR 2.0 genes in this pathway
REACTOME PYRUVATE METABOLISM 1914All SZGR 2.0 genes in this pathway
WATANABE RECTAL CANCER RADIOTHERAPY RESPONSIVE UP 10867All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA DN 526357All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN 663425All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382904All SZGR 2.0 genes in this pathway
BARRIER COLON CANCER RECURRENCE UP 4228All SZGR 2.0 genes in this pathway
DITTMER PTHLH TARGETS DN 7351All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS DN 536332All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 24HR UP 557331All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS UP 293179All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP 552347All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 16521023All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS 988594All SZGR 2.0 genes in this pathway
STARK PREFRONTAL CORTEX 22Q11 DELETION DN 517309All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS UP 424268All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237837All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 6 189112All SZGR 2.0 genes in this pathway
WONG MITOCHONDRIA GENE MODULE 217122All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP 871505All SZGR 2.0 genes in this pathway
MOOTHA HUMAN MITODB 6 2002 429260All SZGR 2.0 genes in this pathway
MOOTHA PGC 420269All SZGR 2.0 genes in this pathway
MOOTHA MITOCHONDRIA 447277All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE DN 841431All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP 756494All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP 682440All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS CALB1 CORR UP 548370All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4 227149All SZGR 2.0 genes in this pathway