Gene Page: ENPP1

Summary ?
GeneID5167
SymbolENPP1
SynonymsARHR2|COLED|M6S1|NPP1|NPPS|PC-1|PCA1|PDNP1
Descriptionectonucleotide pyrophosphatase/phosphodiesterase 1
ReferenceMIM:173335|HGNC:HGNC:3356|Ensembl:ENSG00000197594|HPRD:01415|Vega:OTTHUMG00000015572
Gene typeprotein-coding
Map location6q22-q23
Pascal p-value0.203
DMG1 (# studies)
eGeneCerebellar Hemisphere

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Nishioka_2013Genome-wide DNA methylation analysisThe authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls. 1
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg054179856132128945ENPP1-0.0290.31DMG:Nishioka_2013


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
FGFR40.730.51
HPX0.700.49
KIAA16830.690.52
PLA2G4B0.690.50
IL3RA0.670.50
JMJD7-PLA2G4B0.670.50
CSAD0.670.43
AC008403.10.670.45
CCDC840.670.51
CCNL20.670.44
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
PLA2G4A-0.40-0.46
RGS5-0.40-0.46
CYCS-0.39-0.42
ABCG2-0.39-0.43
NAPB-0.38-0.39
C6orf106-0.38-0.42
TPMT-0.38-0.44
OSTF1-0.37-0.41
CCDC25-0.37-0.41
GHITM-0.37-0.42

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003824catalytic activityIEA-
GO:0003676nucleic acid bindingIEA-
GO:0005158insulin receptor bindingIDA7830796 
GO:0005515protein bindingIPI11289049 
GO:0005524ATP bindingIDA7830796 
GO:0004551nucleotide diphosphatase activityEXP8001561 
GO:0004551nucleotide diphosphatase activityIEA-
GO:0004519endonuclease activityIEA-
GO:0004528phosphodiesterase I activityIEA-
GO:0016787hydrolase activityIEA-
GO:0042803protein homodimerization activityIDA7830796 
GO:0046872metal ion bindingIEA-
GO:00506563'-phosphoadenosine 5'-phosphosulfate bindingIC7830796 
GO:0047429nucleoside-triphosphate diphosphatase activityIDA7830796 |10513816 |11159191 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001503ossificationIEA-
GO:0006091generation of precursor metabolites and energyIDA12746903 
GO:0008152metabolic processIEA-
GO:0006796phosphate metabolic processIDA10513816 |11159191 
GO:0009143nucleoside triphosphate catabolic processIDA10513816 
GO:0030500regulation of bone mineralizationIC10513816 
GO:0030505inorganic diphosphate transportIDA10513816 
GO:0032869cellular response to insulin stimulusIDA7830796 |17849011 
GO:0030279negative regulation of ossificationIEA-
GO:0030308negative regulation of cell growthIDA17849011 
GO:0030730sequestering of triacylglycerolIDA17849011 
GO:0030643cellular phosphate ion homeostasisIDA11159191 
GO:0031953negative regulation of protein amino acid autophosphorylationIDA11289049 
GO:0045599negative regulation of fat cell differentiationIDA17849011 
GO:0045719negative regulation of glycogen biosynthetic processIDA11289049 
GO:0046849bone remodelingIEA-
GO:0046325negative regulation of glucose importIDA17849011 
GO:0046627negative regulation of insulin receptor signaling pathwayIDA7830796 |17849011 
GO:00504273'-phosphoadenosine 5'-phosphosulfate metabolic processIDA7830796 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005615extracellular spaceIDA11159191 
GO:0016021integral to membraneTAS1315502 
GO:0009986cell surfaceIDA10513816 
GO:0005886plasma membraneEXP8001561 
GO:0005886plasma membraneIDA10513816 
GO:0016323basolateral plasma membraneNAS9553761 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG PURINE METABOLISM 15996All SZGR 2.0 genes in this pathway
KEGG STARCH AND SUCROSE METABOLISM 5233All SZGR 2.0 genes in this pathway
KEGG RIBOFLAVIN METABOLISM 1611All SZGR 2.0 genes in this pathway
KEGG NICOTINATE AND NICOTINAMIDE METABOLISM 2416All SZGR 2.0 genes in this pathway
KEGG PANTOTHENATE AND COA BIOSYNTHESIS 169All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF VITAMINS AND COFACTORS 5136All SZGR 2.0 genes in this pathway
NAKAMURA CANCER MICROENVIRONMENT UP 2614All SZGR 2.0 genes in this pathway
BERTUCCI MEDULLARY VS DUCTAL BREAST CANCER DN 169118All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS BASAL UP 380215All SZGR 2.0 genes in this pathway
JAEGER METASTASIS UP 4423All SZGR 2.0 genes in this pathway
GINESTIER BREAST CANCER 20Q13 AMPLIFICATION UP 11966All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC DN 537339All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS DN 781465All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER DN 232154All SZGR 2.0 genes in this pathway
CHEBOTAEV GR TARGETS UP 7762All SZGR 2.0 genes in this pathway
GAUSSMANN MLL AF4 FUSION TARGETS B UP 2616All SZGR 2.0 genes in this pathway
GAUSSMANN MLL AF4 FUSION TARGETS E UP 9760All SZGR 2.0 genes in this pathway
INGRAM SHH TARGETS UP 12779All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR DN 428306All SZGR 2.0 genes in this pathway
GOTZMANN EPITHELIAL TO MESENCHYMAL TRANSITION DN 206136All SZGR 2.0 genes in this pathway
PASQUALUCCI LYMPHOMA BY GC STAGE UP 283177All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 2 UP 256159All SZGR 2.0 genes in this pathway
ROZANOV MMP14 TARGETS UP 266171All SZGR 2.0 genes in this pathway
MANALO HYPOXIA DN 289166All SZGR 2.0 genes in this pathway
MANALO HYPOXIA UP 207145All SZGR 2.0 genes in this pathway
YAGI AML SURVIVAL 12987All SZGR 2.0 genes in this pathway
TRAYNOR RETT SYNDROM DN 1914All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR DN 504323All SZGR 2.0 genes in this pathway
TSENG IRS1 TARGETS DN 13588All SZGR 2.0 genes in this pathway
HEDENFALK BREAST CANCER BRCA1 VS BRCA2 163113All SZGR 2.0 genes in this pathway
TSENG ADIPOGENIC POTENTIAL DN 4628All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS DN 314188All SZGR 2.0 genes in this pathway
MONNIER POSTRADIATION TUMOR ESCAPE DN 373196All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 5 482296All SZGR 2.0 genes in this pathway
GAVIN FOXP3 TARGETS CLUSTER P7 9052All SZGR 2.0 genes in this pathway
ZHENG BOUND BY FOXP3 491310All SZGR 2.0 genes in this pathway
RIGGI EWING SARCOMA PROGENITOR UP 430288All SZGR 2.0 genes in this pathway
HUANG FOXA2 TARGETS UP 4528All SZGR 2.0 genes in this pathway
SMID BREAST CANCER LUMINAL B UP 172109All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL DN 701446All SZGR 2.0 genes in this pathway
JIANG TIP30 TARGETS UP 4628All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA C D DN 252155All SZGR 2.0 genes in this pathway
HOFFMANN PRE BI TO LARGE PRE BII LYMPHOCYTE UP 3624All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER POOR SURVIVAL A6 456285All SZGR 2.0 genes in this pathway
HAN SATB1 TARGETS UP 395249All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069729All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER LATE RECURRENCE DN 6948All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S2 11574All SZGR 2.0 genes in this pathway
BHAT ESR1 TARGETS NOT VIA AKT1 DN 8861All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 2 DN 336211All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP A 898516All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE 1137655All SZGR 2.0 genes in this pathway
PLASARI TGFB1 TARGETS 10HR UP 199143All SZGR 2.0 genes in this pathway
WANG MLL TARGETS 289188All SZGR 2.0 genes in this pathway
RATTENBACHER BOUND BY CELF1 467251All SZGR 2.0 genes in this pathway
ACEVEDO FGFR1 TARGETS IN PROSTATE CANCER MODEL UP 289184All SZGR 2.0 genes in this pathway