Summary ?
GeneID51738
SymbolGHRL
SynonymsMTLRP
Descriptionghrelin/obestatin prepropeptide
ReferenceMIM:605353|HGNC:HGNC:18129|Ensembl:ENSG00000157017|HPRD:05638|Vega:OTTHUMG00000155360
Gene typeprotein-coding
Map location3p25.3
Pascal p-value0.482
Fetal beta-0.173
eGeneCerebellar Hemisphere
Cerebellum
Cortex
Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophreniasClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 6 

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs10994209chr1061877705GHRL517380.16trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0016608growth hormone-releasing hormone activityIEA-
GO:0016608growth hormone-releasing hormone activityISS10604470 
GO:0031768ghrelin receptor bindingISS-
GO:0030296protein tyrosine kinase activator activityIMP15350694 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0051965positive regulation of synaptogenesisIDASynap (GO term level: 10)16491079 
GO:0051965positive regulation of synaptogenesisIEASynap (GO term level: 10)-
GO:0060079regulation of excitatory postsynaptic membrane potentialIEAneuron, Synap (GO term level: 10)-
GO:0016358dendrite developmentIDAneurite, dendrite (GO term level: 11)16491079 
GO:0016358dendrite developmentIEAneurite, dendrite (GO term level: 11)-
GO:0000187activation of MAPK activityIMP15350694 
GO:0001937negative regulation of endothelial cell proliferationIDA15572208 
GO:0030252growth hormone secretionTAS16511605 
GO:0007204elevation of cytosolic calcium ion concentrationISS-
GO:0007186G-protein coupled receptor protein signaling pathwayISS10604470 
GO:0006006glucose metabolic processNAS17392603 
GO:0008343adult feeding behaviorISS-
GO:0009755hormone-mediated signalingTAS16511605 
GO:0008154actin polymerization or depolymerizationIDA15232612 
GO:0043066negative regulation of apoptosisIDA15158140 
GO:0032024positive regulation of insulin secretionISS-
GO:0032100positive regulation of appetiteIEA-
GO:0032100positive regulation of appetiteISS-
GO:0016525negative regulation of angiogenesisNAS15572208 
GO:0040013negative regulation of locomotionIEA-
GO:0042127regulation of cell proliferationIDA15564328 |16394173 
GO:0051216cartilage developmentNAS15576457 
GO:0040018positive regulation of multicellular organism growthIC16511605 
GO:0032691negative regulation of interleukin-1 beta productionIDA15232612 
GO:0043400cortisol secretionNAS17201814 
GO:0042536negative regulation of tumor necrosis factor biosynthetic processIDA15232612 
GO:0050728negative regulation of inflammatory responseIDA15232612 
GO:0043627response to estrogen stimulusIDA15292338 
GO:0046676negative regulation of insulin secretionIEA-
GO:0046697decidualizationIDA17494105 
GO:0045409negative regulation of interleukin-6 biosynthetic processIDA15232612 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0030424axonIDAneuron, axon, Neurotransmitter (GO term level: 6)17113048 
GO:0005576extracellular regionIDA17392603 
GO:0005576extracellular regionIEA-
GO:0005615extracellular spaceIDA15039149 |15531532 
GO:0005737cytoplasmIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
REACTOME GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK 205136All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920449All SZGR 2.0 genes in this pathway
REACTOME PEPTIDE LIGAND BINDING RECEPTORS 188108All SZGR 2.0 genes in this pathway
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS 305177All SZGR 2.0 genes in this pathway
REACTOME DIABETES PATHWAYS 13391All SZGR 2.0 genes in this pathway
REACTOME G ALPHA Q SIGNALLING EVENTS 184116All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING 805368All SZGR 2.0 genes in this pathway
REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN 1611All SZGR 2.0 genes in this pathway
REACTOME GPCR LIGAND BINDING 408246All SZGR 2.0 genes in this pathway
JAZAG TGFB1 SIGNALING DN 3524All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882572All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS DN 366238All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL AND PROGENITOR 681420All SZGR 2.0 genes in this pathway
ROLEF GLIS3 TARGETS 3729All SZGR 2.0 genes in this pathway