Gene Page: PGR
Summary ?
| GeneID | 5241 |
| Symbol | PGR |
| Synonyms | NR3C3|PR |
| Description | progesterone receptor |
| Reference | MIM:607311|HGNC:HGNC:8910|Ensembl:ENSG00000082175|HPRD:07077|Vega:OTTHUMG00000167531 |
| Gene type | protein-coding |
| Map location | 11q22-q23 |
| Pascal p-value | 0.232 |
| Fetal beta | -1.13 |
| DMG | 1 (# studies) |
| eGene | Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Jaffe_2016 | Genome-wide DNA methylation analysis | This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. | 1 |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg13906669 | 11 | 100999399 | PGR | 8.61E-9 | -0.018 | 3.99E-6 | DMG:Jaffe_2016 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs7132043 | chr12 | 80968399 | PGR | 5241 | 0.2 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| BCAS2 | DAM1 | breast carcinoma amplified sequence 2 | BCAS2 interacts with PR. This interaction was modeled on a demonstrated interaction between human BCAS2 and PR from an unspecified species. | BIND | 15694360 |
| CDC25B | - | cell division cycle 25 homolog B (S. pombe) | Reconstituted Complex | BioGRID | 11689696 |
| DAP3 | DAP-3 | DKFZp686G12159 | MGC126058 | MGC126059 | MRP-S29 | MRPS29 | bMRP-10 | death associated protein 3 | Reconstituted Complex | BioGRID | 10903152 |
| DDX54 | DP97 | MGC2835 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 | - | HPRD,BioGRID | 12466272 |
| ESR1 | DKFZp686N23123 | ER | ESR | ESRA | Era | NR3A1 | estrogen receptor 1 | ER-alpha interacts with the PgRA promoter. | BIND | 15019994 |
| ESR1 | DKFZp686N23123 | ER | ESR | ESRA | Era | NR3A1 | estrogen receptor 1 | ER-alpha interacts with the PgRB promoter. | BIND | 15019994 |
| FKBP5 | FKBP51 | FKBP54 | MGC111006 | P54 | PPIase | Ptg-10 | FK506 binding protein 5 | - | HPRD,BioGRID | 12538866 |
| HIST3H3 | H3.4 | H3/g | H3FT | H3t | MGC126886 | MGC126888 | histone cluster 3, H3 | H3 interacts with the PgRA promoter. | BIND | 15019994 |
| HIST3H3 | H3.4 | H3/g | H3FT | H3t | MGC126886 | MGC126888 | histone cluster 3, H3 | H3 interacts with the PgRB promoter. | BIND | 15019994 |
| HIST4H4 | H4/p | MGC24116 | histone cluster 4, H4 | H4 interacts with the PgRB promoter. | BIND | 15019994 |
| HIST4H4 | H4/p | MGC24116 | histone cluster 4, H4 | H4 interacts with the PgRA promoter. | BIND | 15019994 |
| HMGB1 | DKFZp686A04236 | HMG1 | HMG3 | SBP-1 | high-mobility group box 1 | Reconstituted Complex | BioGRID | 9671457 |
| HMGB2 | HMG2 | high-mobility group box 2 | - | HPRD,BioGRID | 9671457 |
| JDP2 | JUNDM2 | Jun dimerization protein 2 | - | HPRD | 12101239 |
| KAT2B | CAF | P | P/CAF | PCAF | K(lysine) acetyltransferase 2B | PRB interacts with PCAF. This interaction is modelled on a demonstrated interaction between human PRB and PCAF from an unspecified species. | BIND | 9223281 |
| KLF9 | BTEB | BTEB1 | Kruppel-like factor 9 | - | HPRD,BioGRID | 12672823 |
| KLF9 | BTEB | BTEB1 | Kruppel-like factor 9 | KLF9 (BTEB1) interacts with PGR (PR-B). | BIND | 12672823 |
| NCOA1 | F-SRC-1 | KAT13A | MGC129719 | MGC129720 | NCoA-1 | RIP160 | SRC-1 | SRC1 | bHLHe42 | nuclear receptor coactivator 1 | - | HPRD,BioGRID | 10757795 |12529333 |
| PIAS2 | MGC102682 | MIZ1 | PIASX | PIASX-ALPHA | PIASX-BETA | SIZ2 | ZMIZ4 | miz | protein inhibitor of activated STAT, 2 | Reconstituted Complex | BioGRID | 11117529 |
| POU2F1 | OCT1 | OTF1 | POU class 2 homeobox 1 | Reconstituted Complex | BioGRID | 10480874 |
| POU2F2 | OCT2 | OTF2 | Oct-2 | POU class 2 homeobox 2 | Reconstituted Complex | BioGRID | 10480874 |
| PRMT2 | HRMT1L1 | MGC111373 | protein arginine methyltransferase 2 | PRMT2 interacts with PR. | BIND | 12039952 |
| RBM23 | CAPERbeta | FLJ10482 | MGC4458 | PP239 | RNPC4 | RNA binding motif protein 23 | RBM23 (CAPER-beta) interacts with PR. | BIND | 15694343 |
| RBM39 | CAPER | CAPERalpha | CC1.3 | DKFZp781C0423 | FLJ44170 | HCC1 | RNPC2 | fSAP59 | RNA binding motif protein 39 | RNPC2 (CAPER-alpha) interacts with PR. | BIND | 15694343 |
| RELA | MGC131774 | NFKB3 | p65 | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | - | HPRD,BioGRID | 8626413 |
| RNF4 | RES4-26 | SNURF | ring finger protein 4 | Two-hybrid | BioGRID | 9710597 |
| SMARCD1 | BAF60A | CRACD1 | Rsc6p | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 | Reconstituted Complex | BioGRID | 12917342 |
| SP1 | - | Sp1 transcription factor | Sp1 interacts with the PgRA promoter. | BIND | 15019994 |
| SP1 | - | Sp1 transcription factor | Sp1 interacts with the PgRB promoter. | BIND | 15019994 |
| TDG | - | thymine-DNA glycosylase | Reconstituted Complex | BioGRID | 12874288 |
| TRIM24 | PTC6 | RNF82 | TF1A | TIF1 | TIF1A | TIF1ALPHA | hTIF1 | tripartite motif-containing 24 | - | HPRD | 9115274 |
| UBE3A | ANCR | AS | E6-AP | EPVE6AP | FLJ26981 | HPVE6A | ubiquitin protein ligase E3A | - | HPRD,BioGRID | 9891052 |
| UBR5 | DD5 | EDD | EDD1 | FLJ11310 | HYD | KIAA0896 | MGC57263 | ubiquitin protein ligase E3 component n-recognin 5 | - | HPRD,BioGRID | 12011095 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG OOCYTE MEIOSIS | 114 | 79 | All SZGR 2.0 genes in this pathway |
| KEGG PROGESTERONE MEDIATED OOCYTE MATURATION | 86 | 59 | All SZGR 2.0 genes in this pathway |
| BIOCARTA MPR PATHWAY | 34 | 28 | All SZGR 2.0 genes in this pathway |
| PID ERA GENOMIC PATHWAY | 65 | 37 | All SZGR 2.0 genes in this pathway |
| PID ANTHRAX PATHWAY | 17 | 15 | All SZGR 2.0 genes in this pathway |
| REACTOME SIGNALING BY ERBB4 | 90 | 67 | All SZGR 2.0 genes in this pathway |
| REACTOME NUCLEAR SIGNALING BY ERBB4 | 38 | 30 | All SZGR 2.0 genes in this pathway |
| REACTOME GENERIC TRANSCRIPTION PATHWAY | 352 | 181 | All SZGR 2.0 genes in this pathway |
| REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | 49 | 36 | All SZGR 2.0 genes in this pathway |
| LIU PROSTATE CANCER DN | 481 | 290 | All SZGR 2.0 genes in this pathway |
| TURASHVILI BREAST LOBULAR CARCINOMA VS LOBULAR NORMAL UP | 94 | 59 | All SZGR 2.0 genes in this pathway |
| CHARAFE BREAST CANCER LUMINAL VS BASAL UP | 380 | 215 | All SZGR 2.0 genes in this pathway |
| DOANE BREAST CANCER ESR1 UP | 112 | 72 | All SZGR 2.0 genes in this pathway |
| GOZGIT ESR1 TARGETS DN | 781 | 465 | All SZGR 2.0 genes in this pathway |
| SUZUKI AMPLIFIED IN ORAL CANCER | 16 | 12 | All SZGR 2.0 genes in this pathway |
| HONRADO BREAST CANCER BRCA1 VS BRCA2 | 18 | 12 | All SZGR 2.0 genes in this pathway |
| SCHLESINGER METHYLATED DE NOVO IN CANCER | 88 | 64 | All SZGR 2.0 genes in this pathway |
| BENPORATH SUZ12 TARGETS | 1038 | 678 | All SZGR 2.0 genes in this pathway |
| BENPORATH EED TARGETS | 1062 | 725 | All SZGR 2.0 genes in this pathway |
| BENPORATH ES WITH H3K27ME3 | 1118 | 744 | All SZGR 2.0 genes in this pathway |
| BENPORATH PRC2 TARGETS | 652 | 441 | All SZGR 2.0 genes in this pathway |
| BYSTRYKH HEMATOPOIESIS STEM CELL RUNX1 | 9 | 6 | All SZGR 2.0 genes in this pathway |
| BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS | 882 | 572 | All SZGR 2.0 genes in this pathway |
| CREIGHTON ENDOCRINE THERAPY RESISTANCE 1 | 528 | 324 | All SZGR 2.0 genes in this pathway |
| CREIGHTON ENDOCRINE THERAPY RESISTANCE 4 | 307 | 185 | All SZGR 2.0 genes in this pathway |
| KONDO PROSTATE CANCER WITH H3K27ME3 | 196 | 93 | All SZGR 2.0 genes in this pathway |
| MASSARWEH TAMOXIFEN RESISTANCE DN | 258 | 160 | All SZGR 2.0 genes in this pathway |
| MASSARWEH RESPONSE TO ESTRADIOL | 61 | 47 | All SZGR 2.0 genes in this pathway |
| MASRI RESISTANCE TO TAMOXIFEN AND AROMATASE INHIBITORS UP | 20 | 10 | All SZGR 2.0 genes in this pathway |
| SMID BREAST CANCER LUMINAL A UP | 84 | 52 | All SZGR 2.0 genes in this pathway |
| SMID BREAST CANCER BASAL DN | 701 | 446 | All SZGR 2.0 genes in this pathway |
| MATZUK OVULATION | 14 | 10 | All SZGR 2.0 genes in this pathway |
| MATZUK IMPLANTATION AND UTERINE | 22 | 15 | All SZGR 2.0 genes in this pathway |
| YOSHIMURA MAPK8 TARGETS UP | 1305 | 895 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN NPC HCP WITH H3K27ME3 | 341 | 243 | All SZGR 2.0 genes in this pathway |
| DUTERTRE ESTRADIOL RESPONSE 6HR UP | 229 | 149 | All SZGR 2.0 genes in this pathway |
| DUTERTRE ESTRADIOL RESPONSE 24HR UP | 324 | 193 | All SZGR 2.0 genes in this pathway |
| BHAT ESR1 TARGETS NOT VIA AKT1 UP | 211 | 131 | All SZGR 2.0 genes in this pathway |
| BHAT ESR1 TARGETS VIA AKT1 UP | 281 | 183 | All SZGR 2.0 genes in this pathway |
| LIM MAMMARY LUMINAL MATURE UP | 116 | 65 | All SZGR 2.0 genes in this pathway |