Gene Page: PLA2G1B

Summary ?
GeneID5319
SymbolPLA2G1B
SynonymsPLA2|PLA2A|PPLA2
Descriptionphospholipase A2 group IB
ReferenceMIM:172410|HGNC:HGNC:9030|Ensembl:ENSG00000170890|HPRD:01396|Vega:OTTHUMG00000169343
Gene typeprotein-coding
Map location12q24.31
Pascal p-value0.3
Fetal beta-0.949

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophreniasClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
GRN0.780.80
TRIM80.780.76
LARS20.750.70
NCSTN0.730.67
KIAA20130.720.71
SHC10.720.70
SIDT20.720.72
C2orf180.720.72
SLC35A40.720.71
ATG2A0.720.71
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
SYCP3-0.54-0.51
AL050337.1-0.51-0.44
FAM159B-0.50-0.56
AF347015.21-0.48-0.38
AC120053.1-0.45-0.36
SPDYA-0.44-0.37
RP9P-0.44-0.43
NOX1-0.44-0.35
GNG11-0.43-0.31
ACSM3-0.43-0.31

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005102receptor bindingIDANeurotransmitter (GO term level: 4)1918029 
GO:0004623phospholipase A2 activityIEA-
GO:0005509calcium ion bindingIEA-
GO:0016787hydrolase activityIEA-
GO:0032052bile acid bindingISS7060561 
GO:0043498cell surface bindingIDA1918029 
GO:0047498calcium-dependent phospholipase A2 activityIDA7060561 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000187activation of MAPK activityISS15528384 |16005851 
GO:0002446neutrophil mediated immunityISS16005851 
GO:0016042lipid catabolic processIEA-
GO:0007243protein kinase cascadeISS15528384 
GO:0010552positive regulation of specific transcription from RNA polymerase II promoterISS15528384 
GO:0010524positive regulation of calcium ion transport into cytosolISS15528384 
GO:0007165signal transductionTAS9886417 
GO:0015758glucose transportISS1918029 
GO:0007015actin filament organizationTAS9886417 
GO:0006644phospholipid metabolic processIEA-
GO:0006633fatty acid biosynthetic processIDA1918029 
GO:0051092positive regulation of NF-kappaB transcription factor activityISS15528384 
GO:0032637interleukin-8 productionISS15528384 
GO:0032869cellular response to insulin stimulusISS1918029 
GO:0019370leukotriene biosynthetic processISS16005851 
GO:0030593neutrophil chemotaxisISS16005851 
GO:0032431activation of phospholipase A2TAS17981679 
GO:0045740positive regulation of DNA replicationIDA1918029 
GO:0048146positive regulation of fibroblast proliferationIC1918029 
GO:0050714positive regulation of protein secretionTAS17981679 
GO:0050778positive regulation of immune responseISS16005851 
GO:0044240multicellular organismal lipid catabolic processIDA7060561 
GO:0046470phosphatidylcholine metabolic processIDA7060561 
GO:0050482arachidonic acid secretionTAS12423354 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
GO:0005615extracellular spaceIDA7060561 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG GLYCEROPHOSPHOLIPID METABOLISM 7735All SZGR 2.0 genes in this pathway
KEGG ETHER LIPID METABOLISM 3315All SZGR 2.0 genes in this pathway
KEGG ARACHIDONIC ACID METABOLISM 5836All SZGR 2.0 genes in this pathway
KEGG LINOLEIC ACID METABOLISM 2916All SZGR 2.0 genes in this pathway
KEGG ALPHA LINOLENIC ACID METABOLISM 199All SZGR 2.0 genes in this pathway
KEGG MAPK SIGNALING PATHWAY 267205All SZGR 2.0 genes in this pathway
KEGG VASCULAR SMOOTH MUSCLE CONTRACTION 11581All SZGR 2.0 genes in this pathway
KEGG VEGF SIGNALING PATHWAY 7653All SZGR 2.0 genes in this pathway
KEGG FC EPSILON RI SIGNALING PATHWAY 7958All SZGR 2.0 genes in this pathway
KEGG LONG TERM DEPRESSION 7053All SZGR 2.0 genes in this pathway
KEGG GNRH SIGNALING PATHWAY 10177All SZGR 2.0 genes in this pathway
PID FCER1 PATHWAY 6243All SZGR 2.0 genes in this pathway
REACTOME ACYL CHAIN REMODELLING OF PI 158All SZGR 2.0 genes in this pathway
REACTOME ACYL CHAIN REMODELLING OF PC 2213All SZGR 2.0 genes in this pathway
REACTOME PHOSPHOLIPID METABOLISM 198112All SZGR 2.0 genes in this pathway
REACTOME SYNTHESIS OF PA 2714All SZGR 2.0 genes in this pathway
REACTOME ACYL CHAIN REMODELLING OF PG 168All SZGR 2.0 genes in this pathway
REACTOME ACYL CHAIN REMODELLING OF PE 2113All SZGR 2.0 genes in this pathway
REACTOME ACYL CHAIN REMODELLING OF PS 157All SZGR 2.0 genes in this pathway
REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS 8239All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS 478302All SZGR 2.0 genes in this pathway
LEE LIVER CANCER DENA DN 7445All SZGR 2.0 genes in this pathway
CHANG IMMORTALIZED BY HPV31 DN 6545All SZGR 2.0 genes in this pathway
MOOTHA MITOCHONDRIA 447277All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR DN 8859All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP 682433All SZGR 2.0 genes in this pathway