Gene Page: PLCB2

Summary ?
GeneID5330
SymbolPLCB2
SynonymsPLC-beta-2
Descriptionphospholipase C beta 2
ReferenceMIM:604114|HGNC:HGNC:9055|Ensembl:ENSG00000137841|HPRD:04985|Vega:OTTHUMG00000172412
Gene typeprotein-coding
Map location15q15
Pascal p-value5.011E-7
Sherlock p-value0.031
Fetal beta-0.694

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:GWAScatGenome-wide Association StudiesThis data set includes 560 SNPs associated with schizophrenia. A total of 486 genes were mapped to these SNPs within 50kb.
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenicClick to show details

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
IGF1R0.950.94
CELSR30.940.96
RAD54L20.940.94
ZNF4620.930.88
ZMIZ10.920.96
KIAA15490.920.96
TRRAP0.920.96
BAT2L0.920.96
INSR0.920.94
GATAD2B0.910.95
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
SERPINB6-0.60-0.75
C5orf53-0.59-0.77
S100B-0.57-0.84
AIFM3-0.57-0.73
AF347015.31-0.57-0.88
HEPN1-0.56-0.71
LHPP-0.56-0.58
TSC22D4-0.56-0.76
B2M-0.56-0.79
FXYD1-0.56-0.85

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG INOSITOL PHOSPHATE METABOLISM 5442All SZGR 2.0 genes in this pathway
KEGG CALCIUM SIGNALING PATHWAY 178134All SZGR 2.0 genes in this pathway
KEGG CHEMOKINE SIGNALING PATHWAY 190128All SZGR 2.0 genes in this pathway
KEGG PHOSPHATIDYLINOSITOL SIGNALING SYSTEM 7656All SZGR 2.0 genes in this pathway
KEGG VASCULAR SMOOTH MUSCLE CONTRACTION 11581All SZGR 2.0 genes in this pathway
KEGG WNT SIGNALING PATHWAY 151112All SZGR 2.0 genes in this pathway
KEGG GAP JUNCTION 9068All SZGR 2.0 genes in this pathway
KEGG LONG TERM POTENTIATION 7057All SZGR 2.0 genes in this pathway
KEGG LONG TERM DEPRESSION 7053All SZGR 2.0 genes in this pathway
KEGG TASTE TRANSDUCTION 5228All SZGR 2.0 genes in this pathway
KEGG GNRH SIGNALING PATHWAY 10177All SZGR 2.0 genes in this pathway
KEGG MELANOGENESIS 10280All SZGR 2.0 genes in this pathway
KEGG ALZHEIMERS DISEASE 169110All SZGR 2.0 genes in this pathway
KEGG HUNTINGTONS DISEASE 185109All SZGR 2.0 genes in this pathway
ST G ALPHA I PATHWAY 3529All SZGR 2.0 genes in this pathway
PID ENDOTHELIN PATHWAY 6352All SZGR 2.0 genes in this pathway
PID ER NONGENOMIC PATHWAY 4135All SZGR 2.0 genes in this pathway
PID TXA2PATHWAY 5743All SZGR 2.0 genes in this pathway
PID S1P S1P1 PATHWAY 2118All SZGR 2.0 genes in this pathway
PID CXCR4 PATHWAY 10278All SZGR 2.0 genes in this pathway
PID THROMBIN PAR4 PATHWAY 1511All SZGR 2.0 genes in this pathway
PID IL8 CXCR2 PATHWAY 3426All SZGR 2.0 genes in this pathway
PID AR NONGENOMIC PATHWAY 3127All SZGR 2.0 genes in this pathway
PID THROMBIN PAR1 PATHWAY 4332All SZGR 2.0 genes in this pathway
PID IL8 CXCR1 PATHWAY 2819All SZGR 2.0 genes in this pathway
PID ALPHA SYNUCLEIN PATHWAY 3325All SZGR 2.0 genes in this pathway
PID RAC1 PATHWAY 5437All SZGR 2.0 genes in this pathway
REACTOME GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK 205136All SZGR 2.0 genes in this pathway
REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES 186155All SZGR 2.0 genes in this pathway
REACTOME NEURONAL SYSTEM 279221All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920449All SZGR 2.0 genes in this pathway
REACTOME INTEGRATION OF ENERGY METABOLISM 12084All SZGR 2.0 genes in this pathway
REACTOME OPIOID SIGNALLING 7856All SZGR 2.0 genes in this pathway
REACTOME NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 137110All SZGR 2.0 genes in this pathway
REACTOME PLC BETA MEDIATED EVENTS 4332All SZGR 2.0 genes in this pathway
REACTOME G ALPHA Q SIGNALLING EVENTS 184116All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF INSULIN SECRETION 9365All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE 119All SZGR 2.0 genes in this pathway
REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA 2012All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING 805368All SZGR 2.0 genes in this pathway
REACTOME G PROTEIN BETA GAMMA SIGNALLING 2818All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 3123All SZGR 2.0 genes in this pathway
SCHRAMM INHBA TARGETS DN 2412All SZGR 2.0 genes in this pathway
HATADA METHYLATED IN LUNG CANCER UP 390236All SZGR 2.0 genes in this pathway
BASSO B LYMPHOCYTE NETWORK 14396All SZGR 2.0 genes in this pathway
PENG GLUTAMINE DEPRIVATION UP 3825All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST UP 398262All SZGR 2.0 genes in this pathway
FERRANDO T ALL WITH MLL ENL FUSION DN 8757All SZGR 2.0 genes in this pathway
THEILGAARD NEUTROPHIL AT SKIN WOUND DN 225163All SZGR 2.0 genes in this pathway
NIELSEN GIST AND SYNOVIAL SARCOMA UP 2015All SZGR 2.0 genes in this pathway
MARIADASON RESPONSE TO BUTYRATE SULINDAC 6 5232All SZGR 2.0 genes in this pathway
SMID BREAST CANCER NORMAL LIKE UP 476285All SZGR 2.0 genes in this pathway
PARK TRETINOIN RESPONSE AND RARA PLZF FUSION 2214All SZGR 2.0 genes in this pathway
MIKKELSEN MEF LCP WITH H3K27ME3 7035All SZGR 2.0 genes in this pathway
MARTENS BOUND BY PML RARA FUSION 456287All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE UP 857456All SZGR 2.0 genes in this pathway
WIERENGA STAT5A TARGETS DN 213127All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP D 280158All SZGR 2.0 genes in this pathway