Gene Page: PLD2

Summary ?
GeneID5338
SymbolPLD2
Synonyms-
Descriptionphospholipase D2
ReferenceMIM:602384|HGNC:HGNC:9068|Ensembl:ENSG00000129219|HPRD:03857|Vega:OTTHUMG00000090779
Gene typeprotein-coding
Map location17p13.1
Pascal p-value0.207
Sherlock p-value0.268
Fetal beta0.229
DMG2 (# studies)
eGeneCerebellar Hemisphere
Cerebellum
Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Nishioka_2013Genome-wide DNA methylation analysisThe authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls. 2
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 2

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg23956071174710044PLD21.131E-4-0.3670.029DMG:Wockner_2014
cg16685860174710619PLD2-0.030.46DMG:Nishioka_2013

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs1038121chr174475243PLD253380.12cis
rs1038118chr174475583PLD253380.14cis
rs16905508chr8137113905PLD253380.08trans
rs11785077chr8137115681PLD253380.08trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACTBPS1TP5BP1actin, beta-HPRD11373276 
ALDOAALDA | MGC10942 | MGC17716 | MGC17767aldolase A, fructose-bisphosphate-HPRD,BioGRID11876650 
AMPHAMPH1amphiphysin-HPRD,BioGRID10764771 
AQP3GILaquaporin 3 (Gill blood group)-HPRD,BioGRID14675200 
ARF1-ADP-ribosylation factor 1Reconstituted ComplexBioGRID10801846 |11373276 
ARF1-ADP-ribosylation factor 1-HPRD10801846 |12519790 
BIN1AMPH2 | AMPHL | DKFZp547F068 | MGC10367 | SH3P9bridging integrator 1-HPRD,BioGRID10764771 
CAV1CAV | MSTP085 | VIP21caveolin 1, caveolae protein, 22kDa-HPRD,BioGRID10675563 
CAV2CAV | MGC12294caveolin 2Co-fractionationBioGRID10675563 
CSKMGC117393c-src tyrosine kinase-HPRD12697812 
EGFRERBB | ERBB1 | HER1 | PIG61 | mENAepidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)-HPRD,BioGRID9837959 
EGFRERBB | ERBB1 | HER1 | PIG61 | mENAepidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)EGFR interacts with PLD1. This interaction was modelled on a demonstrated interaction between human EGFR and mouse PLD2.BIND9837959 
FRAP1FLJ44809 | FRAP | FRAP2 | MTOR | RAFT1 | RAPT1FK506 binding protein 12-rapamycin associated protein 1Affinity Capture-WesternBioGRID16837165 
FYNMGC45350 | SLK | SYNFYN oncogene related to SRC, FGR, YES-HPRD12697812 
GAPDHG3PD | GAPD | MGC88685glyceraldehyde-3-phosphate dehydrogenase-HPRD,BioGRID12753082 
GM2ASAP-3GM2 ganglioside activator-HPRD11672434 
KIAA1303-raptorAffinity Capture-WesternBioGRID16837165 
LCKYT16 | p56lck | pp58lcklymphocyte-specific protein tyrosine kinase-HPRD12697812 
OPRM1KIAA0403 | MOR | MOR1 | OPRMopioid receptor, mu 1-HPRD,BioGRID12519790 
PEA15HMAT1 | HUMMAT1H | MAT1 | MAT1H | PEA-15 | PEDphosphoprotein enriched in astrocytes 15-HPRD,BioGRID10926929 
PIP5K1A-phosphatidylinositol-4-phosphate 5-kinase, type I, alpha-HPRD11032811 
PLCG1PLC-II | PLC1 | PLC148 | PLCgamma1phospholipase C, gamma 1-HPRD,BioGRID12646582 
PLCG1PLC-II | PLC1 | PLC148 | PLCgamma1phospholipase C, gamma 1PLC-gamma1 interacts with PLD2. This interaction was modeled on a demonstrated interaction between PLC-gamma1 from an unspecified species and human PLD2.BIND14744865 
PRKCAAAG6 | MGC129900 | MGC129901 | PKC-alpha | PKCA | PRKACAprotein kinase C, alpha-HPRD,BioGRID11042115 
PRKCDMAY1 | MGC49908 | PKCD | nPKC-deltaprotein kinase C, delta-HPRD,BioGRID11744693 
SRCASV | SRC1 | c-SRC | p60-Srcv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)Affinity Capture-Western
Biochemical Activity
Reconstituted Complex		BioGRID12697812 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG GLYCEROPHOSPHOLIPID METABOLISM 7735All SZGR 2.0 genes in this pathway
KEGG ETHER LIPID METABOLISM 3315All SZGR 2.0 genes in this pathway
KEGG ENDOCYTOSIS 183132All SZGR 2.0 genes in this pathway
KEGG FC GAMMA R MEDIATED PHAGOCYTOSIS 9771All SZGR 2.0 genes in this pathway
KEGG GNRH SIGNALING PATHWAY 10177All SZGR 2.0 genes in this pathway
ST GA12 PATHWAY 2316All SZGR 2.0 genes in this pathway
ST GAQ PATHWAY 2822All SZGR 2.0 genes in this pathway
ST GA13 PATHWAY 3732All SZGR 2.0 genes in this pathway
PID FCER1 PATHWAY 6243All SZGR 2.0 genes in this pathway
PID RHOA PATHWAY 4533All SZGR 2.0 genes in this pathway
PID LYSOPHOSPHOLIPID PATHWAY 6653All SZGR 2.0 genes in this pathway
PID ARF6 TRAFFICKING PATHWAY 4934All SZGR 2.0 genes in this pathway
PID ANGIOPOIETIN RECEPTOR PATHWAY 5041All SZGR 2.0 genes in this pathway
PID ARF6 DOWNSTREAM PATHWAY 1514All SZGR 2.0 genes in this pathway
PID MTOR 4PATHWAY 6955All SZGR 2.0 genes in this pathway
PID ERBB1 DOWNSTREAM PATHWAY 10578All SZGR 2.0 genes in this pathway
PID IL8 CXCR2 PATHWAY 3426All SZGR 2.0 genes in this pathway
PID ARF 3PATHWAY 1913All SZGR 2.0 genes in this pathway
PID ALPHA SYNUCLEIN PATHWAY 3325All SZGR 2.0 genes in this pathway
REACTOME PHOSPHOLIPID METABOLISM 198112All SZGR 2.0 genes in this pathway
REACTOME SYNTHESIS OF PA 2714All SZGR 2.0 genes in this pathway
REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS 8239All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS 478302All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE UP 530342All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 17811082All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN 770415All SZGR 2.0 genes in this pathway
KOYAMA SEMA3B TARGETS DN 411249All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL AND BRAIN QTL TRANS 185114All SZGR 2.0 genes in this pathway
HASLINGER B CLL WITH 17P13 DELETION 2115All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE INCIPIENT UP 390242All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
BOCHKIS FOXA2 TARGETS 425261All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME2 491319All SZGR 2.0 genes in this pathway
JUBAN TARGETS OF SPI1 AND FLI1 DN 9260All SZGR 2.0 genes in this pathway
ROESSLER LIVER CANCER METASTASIS UP 10772All SZGR 2.0 genes in this pathway