Summary ?
GeneID534
SymbolATP6V1G2
SynonymsATP6G|ATP6G2|NG38|VMA10
DescriptionATPase H+ transporting V1 subunit G2
ReferenceMIM:606853|HGNC:HGNC:862|Ensembl:ENSG00000213760|HPRD:06030|Vega:OTTHUMG00000166618
Gene typeprotein-coding
Map location6p21.3
Pascal p-value9.718E-6
Sherlock p-value0.947
SupportION BALANCE
CompositeSet

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
GSMA_IGenome scan meta-analysisPsr: 0.033 
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
SEZ6L20.930.94
ACP20.910.91
GPI0.910.89
SLC45A10.900.91
PCYOX1L0.900.88
CLSTN30.900.93
SLC27A40.900.93
ENO20.900.89
AP2A10.900.90
SV2A0.890.88
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.21-0.60-0.46
AP002478.3-0.57-0.52
AF347015.18-0.57-0.47
NOSTRIN-0.56-0.45
GNG11-0.56-0.50
MT-CO2-0.56-0.44
AC098691.2-0.54-0.48
AF347015.31-0.54-0.43
AF347015.2-0.54-0.39
AF347015.8-0.53-0.42

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIEA-
GO:0005515protein bindingIPI14667819 
GO:0016787hydrolase activityIEA-
GO:0008553hydrogen-exporting ATPase activity, phosphorylative mechanismIEA-
GO:0016887ATPase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006811ion transportIEA-
GO:0015992proton transportIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0030285integral to synaptic vesicle membraneIEASynap (GO term level: 14)-
GO:0016471vacuolar proton-transporting V-type ATPase complexIEA-
GO:0042470melanosomeIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG OXIDATIVE PHOSPHORYLATION 13573All SZGR 2.0 genes in this pathway
KEGG VIBRIO CHOLERAE INFECTION 5632All SZGR 2.0 genes in this pathway
KEGG EPITHELIAL CELL SIGNALING IN HELICOBACTER PYLORI INFECTION 6844All SZGR 2.0 genes in this pathway
REACTOME INSULIN RECEPTOR RECYCLING 239All SZGR 2.0 genes in this pathway
REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 3315All SZGR 2.0 genes in this pathway
REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 413270All SZGR 2.0 genes in this pathway
REACTOME IRON UPTAKE AND TRANSPORT 3618All SZGR 2.0 genes in this pathway
REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING 2510All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY INSULIN RECEPTOR 10872All SZGR 2.0 genes in this pathway
LU AGING BRAIN DN 153120All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237837All SZGR 2.0 genes in this pathway
LEIN NEURON MARKERS 6945All SZGR 2.0 genes in this pathway
MEISSNER ES ICP WITH H3K4ME3 3417All SZGR 2.0 genes in this pathway
MEISSNER NPC ICP WITH H3K4ME3 209All SZGR 2.0 genes in this pathway
MEISSNER BRAIN ICP WITH H3K4ME3 3217All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103714All SZGR 2.0 genes in this pathway
MIKKELSEN ES ICP WITH H3K4ME3 718401All SZGR 2.0 genes in this pathway
MIKKELSEN NPC ICP WITH H3K4ME3 445257All SZGR 2.0 genes in this pathway
FIGUEROA AML METHYLATION CLUSTER 4 UP 11264All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE 1137655All SZGR 2.0 genes in this pathway
BILANGES RAPAMYCIN SENSITIVE VIA TSC1 AND TSC2 7337All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN 1080713All SZGR 2.0 genes in this pathway
ROESSLER LIVER CANCER METASTASIS DN 5329All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839928All SZGR 2.0 genes in this pathway