Gene Page: PLK1

Summary
GeneID  5347
Symbol  PLK1
Synonyms  PLK|STPK13
Description  polo-like kinase 1 (Drosophila)
See related  HGNC:9077|MIM:602098|Ensembl:ENSG00000166851|HPRD:03652|
Locus tag  -
Gene type  protein-coding
Map location  16p12.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.01775 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0005515protein bindingIEA-
GO:0005515protein bindingIPI12493754 |15070733 |15654075 
|16439210 |18329369 
GO:0005524ATP bindingIEA-
GO:0004674protein serine/threonine kinase activityIEA-
GO:0004674protein serine/threonine kinase activityTAS8127874 
GO:0016740transferase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006468protein amino acid phosphorylationIEA-
GO:0007049cell cycleIEA-
GO:0007067mitosisTAS9177283 
GO:0008283cell proliferationTAS8127874 
GO:0051301cell divisionIEA-
GO:0051437positive regulation of ubiquitin-protein ligase activity during mitotic cell cycleEXP10793135 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005813centrosomeIDA11256614 
GO:0005829cytosolEXP15678101 
GO:0005634nucleusIEA-
GO:0005654nucleoplasmEXP11897663 |12738781 |12939256 
|15148369 |15199097 
|15469984 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ASPMASP | Calmbp1 | DKFZp686N06184 | FLJ10517 | FLJ10549 | FLJ43117 | MCPH5asp (abnormal spindle) homolog, microcephaly associated (Drosophila)-HPRD11283617 
BRCA2BRCC2 | FACD | FAD | FAD1 | FANCB | FANCD | FANCD1breast cancer 2, early onsetAffinity Capture-Western
Reconstituted Complex		BioGRID12815053 |14647413 
C7orf20CEE | CGI-20chromosome 7 open reading frame 20Two-hybridBioGRID16169070 
CDC25CCDC25cell division cycle 25 homolog C (S. pombe)-HPRD,BioGRID11202906 
Plk1 phosphorylates an unspecified isoform of CDC25C. This interaction was modeled on a demonstrated phosphorylation of CDC25C from an unspecified species by human Plk1.BIND15766665 
CHEK2CDS1 | CHK2 | HuCds1 | LFS2 | PP1425 | RAD53CHK2 checkpoint homolog (S. pombe)-HPRD,BioGRID12493754 
DCTN1DAP-150 | DP-150 | HMN7B | P135dynactin 1 (p150, glued homolog, Drosophila)Affinity Capture-WesternBioGRID12852857 
DNAJB9DKFZp564F1862 | ERdj4 | MDG1 | MST049 | MSTP049DnaJ (Hsp40) homolog, subfamily B, member 9Two-hybridBioGRID16169070 
GORASP1FLJ23443 | GOLPH5 | GRASP65 | MGC118894 | MGC118897 | P65golgi reassembly stacking protein 1, 65kDa-HPRD11447294 
KIF23CHO1 | KNSL5 | MKLP-1 | MKLP1kinesin family member 23-HPRD8524282 
MAGED1DLXIN-1 | NRAGEmelanoma antigen family D, 1Two-hybridBioGRID16169070 
NPM1B23 | MGC104254 | NPMnucleophosmin (nucleolar phosphoprotein B23, numatrin)-HPRD15190079 
NUDCHNUDC | MNUDC | NPD011nuclear distribution gene C homolog (A. nidulans)-HPRD,BioGRID12852857 
PIN1DOD | UBL5peptidylprolyl cis/trans isomerase, NIMA-interacting 1-HPRD,BioGRID9499405 
Pin1 interacts with PLK1.BIND9499405 
PITPNM1DRES9 | FLJ44997 | NIR2 | PITPNM | RDGB | RDGB1 | RDGBA | RDGBA1 | Rd9phosphatidylinositol transfer protein, membrane-associated 1Nir2 interacts with Plk1.BIND15125835 
PSMA1HC2 | MGC14542 | MGC14575 | MGC14751 | MGC1667 | MGC21459 | MGC22853 | MGC23915 | NU | PROS30proteasome (prosome, macropain) subunit, alpha type, 1Affinity Capture-WesternBioGRID11205743 
PSMA2HC3 | MU | PMSA2 | PSC2proteasome (prosome, macropain) subunit, alpha type, 2Affinity Capture-MSBioGRID11205743 
PSMA3HC8 | MGC12306 | MGC32631 | PSC3proteasome (prosome, macropain) subunit, alpha type, 3-HPRD,BioGRID11205743 
PSMA4HC9 | HsT17706 | MGC111191 | MGC12467 | MGC24813 | PSC9proteasome (prosome, macropain) subunit, alpha type, 4-HPRD,BioGRID11205743 
PSMA5MGC117302 | MGC125802 | MGC125803 | MGC125804 | PSC5 | ZETAproteasome (prosome, macropain) subunit, alpha type, 5-HPRD,BioGRID11205743 
PSMA6IOTA | MGC22756 | MGC2333 | MGC23846 | PROS27 | p27Kproteasome (prosome, macropain) subunit, alpha type, 6Affinity Capture-MS
Affinity Capture-Western		BioGRID11205743 
PSMA7C6 | HSPC | MGC3755 | RC6-1 | XAPC7proteasome (prosome, macropain) subunit, alpha type, 7-HPRD,BioGRID11205743 
PSMB1FLJ25321 | HC5 | KIAA1838 | PMSB1 | PSC5proteasome (prosome, macropain) subunit, beta type, 1-HPRD,BioGRID11205743 
PSMB3HC10-II | MGC4147proteasome (prosome, macropain) subunit, beta type, 3Affinity Capture-MS
Affinity Capture-Western		BioGRID11205743 
PSMB5LMPX | MB1 | MGC104214 | Xproteasome (prosome, macropain) subunit, beta type, 5Affinity Capture-WesternBioGRID11205743 
PSMB6DELTA | LMPY | MGC5169 | Yproteasome (prosome, macropain) subunit, beta type, 6Affinity Capture-WesternBioGRID11205743 
PSMB7Zproteasome (prosome, macropain) subunit, beta type, 7Affinity Capture-WesternBioGRID11205743 
RECQL5FLJ90603 | RECQ5RecQ protein-like 5Two-hybridBioGRID16169070 
TSC1KIAA0243 | LAM | MGC86987 | TSCtuberous sclerosis 1Affinity Capture-WesternBioGRID16339216 
TSC2FLJ43106 | LAM | TSC4tuberous sclerosis 2Affinity Capture-WesternBioGRID16339216 
WEE1DKFZp686I18166 | FLJ16446 | WEE1A | WEE1huWEE1 homolog (S. pombe)Wee1A interacts with and is phophorylated by Plk1. This interaction was modeled on a demonstrated interaction between human Wee1A and mouse Plk1.BIND15070733 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CELL_CYCLE 12884All SZGR genes in this pathway
KEGG_OOCYTE_MEIOSIS 11479All SZGR genes in this pathway
KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION 8659All SZGR genes in this pathway
BIOCARTA_G2_PATHWAY 2420All SZGR genes in this pathway
PID_P73PATHWAY 7959All SZGR genes in this pathway
PID_ATR_PATHWAY 3925All SZGR genes in this pathway
PID_PLK1_PATHWAY 4625All SZGR genes in this pathway
PID_FOXO_PATHWAY 4943All SZGR genes in this pathway
PID_FOXM1_PATHWAY 4030All SZGR genes in this pathway
PID_TAP63_PATHWAY 5440All SZGR genes in this pathway
REACTOME_CELL_CYCLE 421253All SZGR genes in this pathway
REACTOME_CELL_CYCLE_MITOTIC 325185All SZGR genes in this pathway
REACTOME_RECRUITMENT_OF_MITOTIC_CENTROSOME_PROTEINS_AND_COMPLEXES 6643All SZGR genes in this pathway
REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES 5938All SZGR genes in this pathway
REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION 158All SZGR genes in this pathway
REACTOME_REGULATION_OF_MITOTIC_CELL_CYCLE 8546All SZGR genes in this pathway
REACTOME_MITOTIC_M_M_G1_PHASES 17298All SZGR genes in this pathway
REACTOME_MITOTIC_G2_G2_M_PHASES 8150All SZGR genes in this pathway
REACTOME_DNA_REPLICATION 192110All SZGR genes in this pathway
REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 7238All SZGR genes in this pathway
REACTOME_MITOTIC_PROMETAPHASE 8751All SZGR genes in this pathway
REACTOME_PHOSPHORYLATION_OF_THE_APC_C 2310All SZGR genes in this pathway
SOTIRIOU_BREAST_CANCER_GRADE_1_VS_3_UP 15184All SZGR genes in this pathway
GAZDA_DIAMOND_BLACKFAN_ANEMIA_ERYTHROID_DN 493298All SZGR genes in this pathway
CASORELLI_ACUTE_PROMYELOCYTIC_LEUKEMIA_DN 663425All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_DN 460312All SZGR genes in this pathway
HORIUCHI_WTAP_TARGETS_DN 310188All SZGR genes in this pathway
GAL_LEUKEMIC_STEM_CELL_DN 244153All SZGR genes in this pathway
BASAKI_YBX1_TARGETS_UP 290177All SZGR genes in this pathway
GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_TURQUOISE_DN 5325All SZGR genes in this pathway
ODONNELL_TFRC_TARGETS_DN 13976All SZGR genes in this pathway
TIEN_INTESTINE_PROBIOTICS_24HR_UP 557331All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_FIMA_UP 544308All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP 1278748All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_1_DN 378231All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_3_UP 329196All SZGR genes in this pathway
MARKEY_RB1_ACUTE_LOF_DN 228137All SZGR genes in this pathway
CONCANNON_APOPTOSIS_BY_EPOXOMICIN_DN 172112All SZGR genes in this pathway
JOHANSSON_GLIOMAGENESIS_BY_PDGFB_UP 5844All SZGR genes in this pathway
OLSSON_E2F3_TARGETS_DN 4933All SZGR genes in this pathway
KONG_E2F3_TARGETS 9758All SZGR genes in this pathway
RASHI_RESPONSE_TO_IONIZING_RADIATION_5 14789All SZGR genes in this pathway
ROSTY_CERVICAL_CANCER_PROLIFERATION_CLUSTER 14073All SZGR genes in this pathway
HERNANDEZ_MITOTIC_ARREST_BY_DOCETAXEL_2_UP 6445All SZGR genes in this pathway
XU_HGF_SIGNALING_NOT_VIA_AKT1_48HR_DN 2012All SZGR genes in this pathway
PATIL_LIVER_CANCER 747453All SZGR genes in this pathway
MOHANKUMAR_TLX1_TARGETS_UP 414287All SZGR genes in this pathway
TSAI_RESPONSE_TO_IONIZING_RADIATION 149101All SZGR genes in this pathway
KARAKAS_TGFB1_SIGNALING 1815All SZGR genes in this pathway
PUJANA_BREAST_CANCER_LIT_INT_NETWORK 10173All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_CHEK2_PCC_NETWORK 779480All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_DN 1024594All SZGR genes in this pathway
KOYAMA_SEMA3B_TARGETS_DN 411249All SZGR genes in this pathway
BENPORATH_MYC_TARGETS_WITH_EBOX 230156All SZGR genes in this pathway
BENPORATH_CYCLING_GENES 648385All SZGR genes in this pathway
LE_EGR2_TARGETS_UP 10875All SZGR genes in this pathway
PEART_HDAC_PROLIFERATION_CLUSTER_DN 7657All SZGR genes in this pathway
SASAKI_ADULT_T_CELL_LEUKEMIA 176122All SZGR genes in this pathway
YU_MYC_TARGETS_UP 4226All SZGR genes in this pathway
PETROVA_ENDOTHELIUM_LYMPHATIC_VS_BLOOD_UP 13187All SZGR genes in this pathway
AFFAR_YY1_TARGETS_DN 234137All SZGR genes in this pathway
HOEGERKORP_CD44_TARGETS_TEMPORAL_DN 2516All SZGR genes in this pathway
RHODES_CANCER_META_SIGNATURE 6447All SZGR genes in this pathway
KAAB_HEART_ATRIUM_VS_VENTRICLE_UP 249170All SZGR genes in this pathway
CHUANG_OXIDATIVE_STRESS_RESPONSE_DN 119All SZGR genes in this pathway
KANG_DOXORUBICIN_RESISTANCE_UP 5433All SZGR genes in this pathway
BURTON_ADIPOGENESIS_3 10164All SZGR genes in this pathway
LY_AGING_OLD_DN 5635All SZGR genes in this pathway
LY_AGING_MIDDLE_DN 1610All SZGR genes in this pathway
MARTINEZ_RESPONSE_TO_TRABECTEDIN_DN 271175All SZGR genes in this pathway
GAVIN_FOXP3_TARGETS_CLUSTER_P6 9144All SZGR genes in this pathway
MARSON_BOUND_BY_E2F4_UNSTIMULATED 728415All SZGR genes in this pathway
HELLER_SILENCED_BY_METHYLATION_UP 282183All SZGR genes in this pathway
HELLER_HDAC_TARGETS_DN 292189All SZGR genes in this pathway
AMUNDSON_GAMMA_RADIATION_RESPONSE 4025All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_UP 673430All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_DN 593372All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_DN 591366All SZGR genes in this pathway
FINETTI_BREAST_CANCER_KINOME_RED 1611All SZGR genes in this pathway
SARRIO_EPITHELIAL_MESENCHYMAL_TRANSITION_UP 180114All SZGR genes in this pathway
RIZKI_TUMOR_INVASIVENESS_3D_DN 270181All SZGR genes in this pathway
TOYOTA_TARGETS_OF_MIR34B_AND_MIR34C 463262All SZGR genes in this pathway
ZHENG_GLIOBLASTOMA_PLASTICITY_UP 250168All SZGR genes in this pathway
GRADE_COLON_AND_RECTAL_CANCER_UP 285167All SZGR genes in this pathway
MALONEY_RESPONSE_TO_17AAG_DN 7945All SZGR genes in this pathway
BLUM_RESPONSE_TO_SALIRASIB_DN 342220All SZGR genes in this pathway
FIRESTEIN_CTNNB1_PATHWAY 3323All SZGR genes in this pathway
GOLDRATH_ANTIGEN_RESPONSE 346192All SZGR genes in this pathway
ICHIBA_GRAFT_VERSUS_HOST_DISEASE_35D_UP 13179All SZGR genes in this pathway
CHANG_CYCLING_GENES 14883All SZGR genes in this pathway
ZHANG_TLX_TARGETS_60HR_DN 277166All SZGR genes in this pathway
COLINA_TARGETS_OF_4EBP1_AND_4EBP2 356214All SZGR genes in this pathway
MILI_PSEUDOPODIA_HAPTOTAXIS_DN 668419All SZGR genes in this pathway
CROONQUIST_IL6_DEPRIVATION_DN 9869All SZGR genes in this pathway
CROONQUIST_NRAS_SIGNALING_DN 7247All SZGR genes in this pathway
KOBAYASHI_EGFR_SIGNALING_24HR_DN 251151All SZGR genes in this pathway
FOURNIER_ACINAR_DEVELOPMENT_LATE_2 277172All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_CLASSES_UP 605377All SZGR genes in this pathway
WONG_EMBRYONIC_STEM_CELL_CORE 335193All SZGR genes in this pathway
WHITFIELD_CELL_CYCLE_LITERATURE 4425All SZGR genes in this pathway
WHITFIELD_CELL_CYCLE_G2_M 216124All SZGR genes in this pathway
WANG_METASTASIS_OF_BREAST_CANCER_ESR1_UP 2214All SZGR genes in this pathway
MARTENS_TRETINOIN_RESPONSE_DN 841431All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_24HR_UP 324193All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_NOT_SATB1_UP 344215All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_UP 570339All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_BOUND_8D 658397All SZGR genes in this pathway
REICHERT_MITOSIS_LIN9_TARGETS 2817All SZGR genes in this pathway
SMIRNOV_RESPONSE_TO_IR_6HR_DN 11469All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_1ST_EGF_PULSE_ONLY 1839928All SZGR genes in this pathway


Copyright © Bioinformatics and Systems Medicine Laboratory All Rights Reserved since 2009.