SZGR2

Summary ?

GeneID	5411
Symbol	PNN
Synonyms	DRS\|DRSP\|SDK3\|memA
Description	pinin, desmosome associated protein
Reference	MIM:603154\|HGNC:HGNC:9162\|Ensembl:ENSG00000100941\|HPRD:04401\|Vega:OTTHUMG00000028821
Gene type	protein-coding
Map location	14q21.1
Pascal p-value	0.511
DEG p-value	DEG:Maycox_2009:CC_BA10_fold_change=1.09:CC_BA10_disease_P=0.0011:HBB_BA9_fold_change=1.19:HBB_BA9_disease_P=0.0151
Fetal beta	1.263

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DEG:Maycox_2009	Microarray to determine the expression of over 30000 mRNA transcripts in post-mortem tissue	We included 51 genes whose expression changes are common between two schizophrenia cohorts.
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias	Click to show details

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
LSMD1	0.77	0.56
BRP44L	0.73	0.49
PSMB10	0.73	0.58
CNFN	0.72	0.45
NDUFB7	0.71	0.44
MYEOV2	0.70	0.48
A1BG	0.69	0.23
NDUFA1	0.69	0.37
NDUFA13	0.69	0.48
CHCHD10	0.68	0.48

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
ZNF418	-0.40	-0.54
ZNF211	-0.38	-0.50
PTPN12	-0.38	-0.48
ZNF841	-0.37	-0.51
ZNF589	-0.37	-0.50
THOC2	-0.36	-0.46
ERCC5	-0.36	-0.45
USP34	-0.36	-0.43
ZNF17	-0.36	-0.49
MLL5	-0.36	-0.49

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
CTBP1	BARS \| MGC104684	C-terminal binding protein 1	-	HPRD,BioGRID	15542832
CTBP2	-	C-terminal binding protein 2	-	HPRD	15542832
KRT18	CYK18 \| K18	keratin 18	-	HPRD,BioGRID	10809736
KRT19	CK19 \| K19 \| K1CS \| MGC15366	keratin 19	-	HPRD,BioGRID	10809736
KRT8	CARD2 \| CK8 \| CYK8 \| K2C8 \| K8 \| KO	keratin 8	-	HPRD,BioGRID	10809736
NFKBIL1	IKBL \| LST1 \| NFKBIL	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1	Affinity Capture-MS	BioGRID	17353931
PPIG	CARS-Cyp \| CYP \| MGC133241 \| SRCyp	peptidylprolyl isomerase G (cyclophilin G)	-	HPRD,BioGRID	15358154
PRPF4B	KIAA0536 \| PR4H \| PRP4 \| PRP4H \| PRP4K \| dJ1013A10.1	PRP4 pre-mRNA processing factor 4 homolog B (yeast)	-	HPRD,BioGRID	12077342
RNPS1	E5.1 \| MGC117332	RNA binding protein S1, serine-rich domain	-	HPRD,BioGRID	14517304
SFRS18	C6orf111 \| DKFZp564B0769 \| FLJ14752 \| FLJ14853 \| FLJ14992 \| FLJ90147 \| HSPC306 \| MGC104269 \| RP11-98I9.2 \| SRrp130 \| bA98I9.2	splicing factor, arginine/serine-rich 18	Pnn interacts with SRrp130.	BIND	14578391
SFRS18	C6orf111 \| DKFZp564B0769 \| FLJ14752 \| FLJ14853 \| FLJ14992 \| FLJ90147 \| HSPC306 \| MGC104269 \| RP11-98I9.2 \| SRrp130 \| bA98I9.2	splicing factor, arginine/serine-rich 18	-	HPRD,BioGRID	14578391
SFRS4	SRP75	splicing factor, arginine/serine-rich 4	-	HPRD,BioGRID	14578391
SFRS4	SRP75	splicing factor, arginine/serine-rich 4	Pnn interacts with SRp75.	BIND	14578391
SRRM2	300-KD \| CWF21 \| DKFZp686O15166 \| FLJ21926 \| FLJ22250 \| KIAA0324 \| MGC40295 \| SRL300 \| SRm300	serine/arginine repetitive matrix 2	Pnn interacts with SRm300.	BIND	14578391
SRRM2	300-KD \| CWF21 \| DKFZp686O15166 \| FLJ21926 \| FLJ22250 \| KIAA0324 \| MGC40295 \| SRL300 \| SRm300	serine/arginine repetitive matrix 2	-	HPRD,BioGRID	14578391
YWHAG	14-3-3GAMMA	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	-	HPRD	15324660
ZCCHC17	HSPC251 \| PS1D \| RP11-266K22.1 \| pNO40	zinc finger, CCHC domain containing 17	-	HPRD,BioGRID	12893261

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL DN	634	384	All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS DN	431	263	All SZGR 2.0 genes in this pathway
PUIFFE INVASION INHIBITED BY ASCITES DN	145	91	All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP	1382	904	All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL UP	450	256	All SZGR 2.0 genes in this pathway
GINESTIER BREAST CANCER 20Q13 AMPLIFICATION DN	180	101	All SZGR 2.0 genes in this pathway
HOEBEKE LYMPHOID STEM CELL UP	95	64	All SZGR 2.0 genes in this pathway
UDAYAKUMAR MED1 TARGETS DN	240	171	All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 24HR UP	557	331	All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS 12HR DN	209	122	All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN	1375	806	All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC UP	722	443	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN	1781	1082	All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN	770	415	All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL UP	584	356	All SZGR 2.0 genes in this pathway
OUELLET CULTURED OVARIAN CANCER INVASIVE VS LMP UP	69	40	All SZGR 2.0 genes in this pathway
PUJANA XPRSS INT NETWORK	168	103	All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK	1652	1023	All SZGR 2.0 genes in this pathway
PUJANA BRCA2 PCC NETWORK	423	265	All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK	1442	892	All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK	779	480	All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS UP	769	437	All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS DN	637	377	All SZGR 2.0 genes in this pathway
LOCKWOOD AMPLIFIED IN LUNG CANCER	214	139	All SZGR 2.0 genes in this pathway
RICKMAN METASTASIS UP	344	180	All SZGR 2.0 genes in this pathway
BENPORATH ES 1	379	235	All SZGR 2.0 genes in this pathway
BENPORATH CYCLING GENES	648	385	All SZGR 2.0 genes in this pathway
THEILGAARD NEUTROPHIL AT SKIN WOUND DN	225	163	All SZGR 2.0 genes in this pathway
NGUYEN NOTCH1 TARGETS DN	86	67	All SZGR 2.0 genes in this pathway
YAGI AML FAB MARKERS	191	131	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN	1237	837	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 10HR DN	56	37	All SZGR 2.0 genes in this pathway
WANG SMARCE1 TARGETS DN	371	218	All SZGR 2.0 genes in this pathway
WANG CISPLATIN RESPONSE AND XPC DN	228	146	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 14HR UP	156	101	All SZGR 2.0 genes in this pathway
GENTILE UV RESPONSE CLUSTER D2	41	30	All SZGR 2.0 genes in this pathway
GENTILE UV HIGH DOSE DN	312	203	All SZGR 2.0 genes in this pathway
MONNIER POSTRADIATION TUMOR ESCAPE UP	393	244	All SZGR 2.0 genes in this pathway
STEARMAN LUNG CANCER EARLY VS LATE UP	125	89	All SZGR 2.0 genes in this pathway
IWANAGA CARCINOGENESIS BY KRAS UP	170	107	All SZGR 2.0 genes in this pathway
DE YY1 TARGETS DN	92	64	All SZGR 2.0 genes in this pathway
ACEVEDO NORMAL TISSUE ADJACENT TO LIVER TUMOR UP	174	96	All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP	973	570	All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP	871	505	All SZGR 2.0 genes in this pathway
BHATI G2M ARREST BY 2METHOXYESTRADIOL UP	125	68	All SZGR 2.0 genes in this pathway
WINTER HYPOXIA METAGENE	242	168	All SZGR 2.0 genes in this pathway
MUELLER PLURINET	299	189	All SZGR 2.0 genes in this pathway
WANG TUMOR INVASIVENESS UP	374	247	All SZGR 2.0 genes in this pathway
CHANG CORE SERUM RESPONSE UP	212	128	All SZGR 2.0 genes in this pathway
YAGI AML WITH INV 16 TRANSLOCATION	422	277	All SZGR 2.0 genes in this pathway
PUJANA BREAST CANCER WITH BRCA1 MUTATED UP	56	27	All SZGR 2.0 genes in this pathway
KOBAYASHI EGFR SIGNALING 24HR DN	251	151	All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S2	115	74	All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE G1 S	147	76	All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE DN	841	431	All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN	918	550	All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN	882	538	All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS DN	553	343	All SZGR 2.0 genes in this pathway
YUAN ZNF143 PARTNERS	22	15	All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN	1080	713	All SZGR 2.0 genes in this pathway
HOLLEMAN VINCRISTINE RESISTANCE B ALL UP	38	22	All SZGR 2.0 genes in this pathway

Gene Page: PNN