Gene Page: POLR2H

Summary ?
GeneID5437
SymbolPOLR2H
SynonymsRPABC3|RPB17|RPB8
Descriptionpolymerase (RNA) II subunit H
ReferenceMIM:606023|HGNC:HGNC:9195|Ensembl:ENSG00000163882|HPRD:09082|Vega:OTTHUMG00000156746
Gene typeprotein-coding
Map location3q28
Pascal p-value0.859
Sherlock p-value0.731
Fetal beta-0.324
DMG1 (# studies)

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg162794643184080807POLR2H1.37E-8-0.015.39E-6DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
CNOT60.980.97
MYST30.980.96
ARID20.970.98
LATS10.970.98
MSL20.970.97
RFX70.970.98
C11orf300.970.97
CRKRS0.970.98
PBRM10.970.98
RBM160.970.97
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.31-0.73-0.89
MT-CO2-0.72-0.90
C5orf53-0.72-0.76
FXYD1-0.72-0.89
AIFM3-0.71-0.77
AF347015.27-0.71-0.86
HLA-F-0.71-0.76
IFI27-0.71-0.87
S100B-0.71-0.83
AF347015.33-0.70-0.85

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CD40Bp50 | CDW40 | MGC9013 | TNFRSF5 | p50CD40 molecule, TNF receptor superfamily member 5Affinity Capture-MSBioGRID17353931 
MED10L6 | MGC5309 | NUT2 | TRG20mediator complex subunit 10Affinity Capture-MSBioGRID15175163 
MED19DT2P1G7 | LCMR1mediator complex subunit 19Affinity Capture-MSBioGRID15175163 
MED26CRSP7 | CRSP70mediator complex subunit 26Affinity Capture-MSBioGRID15175163 
MED29DKFZp434H247 | IXLmediator complex subunit 29Affinity Capture-MSBioGRID15175163 
NME2MGC111212 | NDPK-B | NDPKB | NM23-H2 | NM23B | pufnon-metastatic cells 2, protein (NM23B) expressed inAffinity Capture-MSBioGRID17353931 
POLR2AMGC75453 | POLR2 | POLRA | RPB1 | RPBh1 | RPO2 | RPOL2 | RpIILS | hRPB220 | hsRPB1polymerase (RNA) II (DNA directed) polypeptide A, 220kDaReconstituted ComplexBioGRID9201987 
POLR2AMGC75453 | POLR2 | POLRA | RPB1 | RPBh1 | RPO2 | RPOL2 | RpIILS | hRPB220 | hsRPB1polymerase (RNA) II (DNA directed) polypeptide A, 220kDaPOLR2H (hRPB8) interacts with POLR2A (hRPB1).BIND9201987 
POLR2AMGC75453 | POLR2 | POLRA | RPB1 | RPBh1 | RPO2 | RPOL2 | RpIILS | hRPB220 | hsRPB1polymerase (RNA) II (DNA directed) polypeptide A, 220kDahRPB1 interacts with hRPB8.BIND10567706 
POLR2BPOL2RB | RPB2 | hRPB140 | hsRPB2polymerase (RNA) II (DNA directed) polypeptide B, 140kDaPOLR2H (hRPB8) interacts weakly with POLR2B (hRPB2).BIND9201987 
POLR2BPOL2RB | RPB2 | hRPB140 | hsRPB2polymerase (RNA) II (DNA directed) polypeptide B, 140kDahRPB2 interacts weakly with hRPB8.BIND10567706 
POLR2BPOL2RB | RPB2 | hRPB140 | hsRPB2polymerase (RNA) II (DNA directed) polypeptide B, 140kDaReconstituted ComplexBioGRID9201987 
POLR2CRPB3 | RPB31 | hRPB33 | hsRPB3polymerase (RNA) II (DNA directed) polypeptide C, 33kDaPOLR2H (hRPB8) interacts with POLR2C (hRPB3).BIND9201987 
POLR2CRPB3 | RPB31 | hRPB33 | hsRPB3polymerase (RNA) II (DNA directed) polypeptide C, 33kDaReconstituted ComplexBioGRID9201987 
POLR2DHSRBP4 | HSRPB4 | RBP4polymerase (RNA) II (DNA directed) polypeptide DhRPB4 interacts weakly with hRPB8.BIND10567706 
POLR2ERPABC1 | RPB5 | XAP4 | hRPB25 | hsRPB5polymerase (RNA) II (DNA directed) polypeptide E, 25kDaPOLR2H (hRPB8) interacts with POLR2E (hRPB5).BIND9201987 
POLR2ERPABC1 | RPB5 | XAP4 | hRPB25 | hsRPB5polymerase (RNA) II (DNA directed) polypeptide E, 25kDaReconstituted ComplexBioGRID9201987 
POLR2GMGC138367 | MGC138369 | RPB7 | hRPB19 | hsRPB7polymerase (RNA) II (DNA directed) polypeptide GPOLR2H (hRPB8) interacts weakly with POLR2G (hRPB7).BIND9201987 
POLR2GMGC138367 | MGC138369 | RPB7 | hRPB19 | hsRPB7polymerase (RNA) II (DNA directed) polypeptide GReconstituted ComplexBioGRID9201987 
POLR2HRPABC3 | RPB17 | RPB8 | hsRPB8polymerase (RNA) II (DNA directed) polypeptide HPOLR2H (hRPB8) interacts weakly with POLR2H (hRPB8).BIND9201987 
POLR2HRPABC3 | RPB17 | RPB8 | hsRPB8polymerase (RNA) II (DNA directed) polypeptide HReconstituted ComplexBioGRID9201987 
POLR2KABC10-alpha | RPABC4 | RPB10alpha | RPB12 | RPB7.0 | hRPB7.0 | hsRPB10apolymerase (RNA) II (DNA directed) polypeptide K, 7.0kDaPOLR2H (hRPB8) interacts with POLR2K (hRPB10-alpha).BIND9201987 
POLR2KABC10-alpha | RPABC4 | RPB10alpha | RPB12 | RPB7.0 | hRPB7.0 | hsRPB10apolymerase (RNA) II (DNA directed) polypeptide K, 7.0kDaReconstituted ComplexBioGRID9201987 
POLR2LRBP10 | RPABC5 | RPB10 | RPB10beta | RPB7.6 | hRPB7.6 | hsRPB10bpolymerase (RNA) II (DNA directed) polypeptide L, 7.6kDaReconstituted ComplexBioGRID9201987 
POLR2LRBP10 | RPABC5 | RPB10 | RPB10beta | RPB7.6 | hRPB7.6 | hsRPB10bpolymerase (RNA) II (DNA directed) polypeptide L, 7.6kDahRPB8 interacts weakly with hRPB10-beta.BIND10567706 
POLR3DBN51T | RPC4 | RPC53 | TSBN51polymerase (RNA) III (DNA directed) polypeptide D, 44kDaAffinity Capture-MSBioGRID12391170 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG PURINE METABOLISM 15996All SZGR 2.0 genes in this pathway
KEGG PYRIMIDINE METABOLISM 9853All SZGR 2.0 genes in this pathway
KEGG RNA POLYMERASE 2912All SZGR 2.0 genes in this pathway
KEGG HUNTINGTONS DISEASE 185109All SZGR 2.0 genes in this pathway
REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 2312All SZGR 2.0 genes in this pathway
REACTOME RNA POL I TRANSCRIPTION TERMINATION 2212All SZGR 2.0 genes in this pathway
REACTOME MICRORNA MIRNA BIOGENESIS 239All SZGR 2.0 genes in this pathway
REACTOME REGULATORY RNA PATHWAYS 2612All SZGR 2.0 genes in this pathway
REACTOME PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA 14077All SZGR 2.0 genes in this pathway
REACTOME RNA POL I TRANSCRIPTION 8964All SZGR 2.0 genes in this pathway
REACTOME RNA POL II TRANSCRIPTION 10554All SZGR 2.0 genes in this pathway
REACTOME RNA POL III TRANSCRIPTION 3318All SZGR 2.0 genes in this pathway
REACTOME MRNA CAPPING 3011All SZGR 2.0 genes in this pathway
REACTOME TRANSCRIPTION COUPLED NER TC NER 4524All SZGR 2.0 genes in this pathway
REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING 4121All SZGR 2.0 genes in this pathway
REACTOME MRNA PROCESSING 16186All SZGR 2.0 genes in this pathway
REACTOME MRNA SPLICING 11158All SZGR 2.0 genes in this pathway
REACTOME MRNA SPLICING MINOR PATHWAY 4519All SZGR 2.0 genes in this pathway
REACTOME TRANSCRIPTION 210127All SZGR 2.0 genes in this pathway
REACTOME NUCLEOTIDE EXCISION REPAIR 5127All SZGR 2.0 genes in this pathway
REACTOME FORMATION OF RNA POL II ELONGATION COMPLEX 4519All SZGR 2.0 genes in this pathway
REACTOME ELONGATION ARREST AND RECOVERY 3214All SZGR 2.0 genes in this pathway
REACTOME FORMATION OF TRANSCRIPTION COUPLED NER TC NER REPAIR COMPLEX 3013All SZGR 2.0 genes in this pathway
REACTOME RNA POL I RNA POL III AND MITOCHONDRIAL TRANSCRIPTION 12280All SZGR 2.0 genes in this pathway
REACTOME DNA REPAIR 11259All SZGR 2.0 genes in this pathway
REACTOME RNA POL II PRE TRANSCRIPTION EVENTS 6132All SZGR 2.0 genes in this pathway
REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 2613All SZGR 2.0 genes in this pathway
REACTOME INFLUENZA LIFE CYCLE 20372All SZGR 2.0 genes in this pathway
REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION 16947All SZGR 2.0 genes in this pathway
REACTOME HIV INFECTION 207122All SZGR 2.0 genes in this pathway
REACTOME HIV LIFE CYCLE 12569All SZGR 2.0 genes in this pathway
REACTOME ABORTIVE ELONGATION OF HIV1 TRANSCRIPT IN THE ABSENCE OF TAT 237All SZGR 2.0 genes in this pathway
REACTOME RNA POL III TRANSCRIPTION TERMINATION 1910All SZGR 2.0 genes in this pathway
REACTOME FORMATION OF THE HIV1 EARLY ELONGATION COMPLEX 3411All SZGR 2.0 genes in this pathway
REACTOME LATE PHASE OF HIV LIFE CYCLE 10461All SZGR 2.0 genes in this pathway
REACTOME RNA POL III CHAIN ELONGATION 178All SZGR 2.0 genes in this pathway
REACTOME RNA POL I TRANSCRIPTION INITIATION 2514All SZGR 2.0 genes in this pathway
SLEBOS HEAD AND NECK CANCER WITH HPV UP 8443All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375806All SZGR 2.0 genes in this pathway
LUND SILENCED BY METHYLATION 1612All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 16521023All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK 779480All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS 957597All SZGR 2.0 genes in this pathway
LOCKWOOD AMPLIFIED IN LUNG CANCER 214139All SZGR 2.0 genes in this pathway
BASSO B LYMPHOCYTE NETWORK 14396All SZGR 2.0 genes in this pathway
KUROKAWA LIVER CANCER CHEMOTHERAPY DN 4128All SZGR 2.0 genes in this pathway
YAGI AML RELAPSE PROGNOSIS 3524All SZGR 2.0 genes in this pathway
FLECHNER PBL KIDNEY TRANSPLANT REJECTED VS OK DN 5135All SZGR 2.0 genes in this pathway
SCHUHMACHER MYC TARGETS UP 8057All SZGR 2.0 genes in this pathway
COLLER MYC TARGETS UP 2519All SZGR 2.0 genes in this pathway
SASAKI ADULT T CELL LEUKEMIA 176122All SZGR 2.0 genes in this pathway
NADLER HYPERGLYCEMIA AT OBESITY 5835All SZGR 2.0 genes in this pathway
YAGI AML SURVIVAL 12987All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 16HR UP 225139All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR UP 180125All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 14HR UP 156101All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 18HR UP 178111All SZGR 2.0 genes in this pathway
ZHANG RESPONSE TO CANTHARIDIN DN 6946All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR DN 911527All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR DN 1011592All SZGR 2.0 genes in this pathway
DAIRKEE CANCER PRONE RESPONSE BPA E2 11865All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP 863514All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
JISON SICKLE CELL DISEASE DN 18197All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA CD2 DN 4629All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 19721213All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D 882506All SZGR 2.0 genes in this pathway
KRIEG HYPOXIA NOT VIA KDM3A 770480All SZGR 2.0 genes in this pathway