Gene Page: POMC

Summary ?
GeneID5443
SymbolPOMC
SynonymsACTH|CLIP|LPH|MSH|NPP|POC
Descriptionproopiomelanocortin
ReferenceMIM:176830|HGNC:HGNC:9201|Ensembl:ENSG00000115138|HPRD:01462|Vega:OTTHUMG00000094764
Gene typeprotein-coding
Map location2p23.3
Pascal p-value3.386E-5
Sherlock p-value0.481
Fetal beta-0.585
eGeneMyers' cis & trans
Meta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophrenias,schizotypalClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs7565427chr225385637POMC54430.04cis
rs13031634chr225585652POMC54430.05cis
rs2197741chr3108732108POMC54430.01trans
rs11733243chr44944450POMC54430.18trans
rs6063623chr2049906075POMC54430.03trans
rs6067724chr2049907840POMC54430.03trans
rs11696172chr2049912433POMC54430.02trans
rs391008chrX44582706POMC54430.02trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
FAM19A10.780.84
RND10.720.77
TCEAL10.720.80
PRPS20.720.75
AC012652.10.710.75
PVRL30.690.74
FABP30.680.75
TM6SF10.670.79
IL12RB20.670.77
R3HDM10.670.75
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
SORBS3-0.51-0.56
PLXNB1-0.49-0.49
CASKIN2-0.45-0.47
NFKB2-0.42-0.51
TRIP6-0.42-0.49
EML3-0.41-0.43
MAPKAPK3-0.41-0.45
ACP6-0.41-0.43
SLC9A3R1-0.40-0.43
SLC2A4RG-0.40-0.47

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005179hormone activityIEA-
GO:0005179hormone activityTAS9620771 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007218neuropeptide signaling pathwayIEANeurotransmitter (GO term level: 8)-
GO:0008217regulation of blood pressureIEA-
GO:0007267cell-cell signalingTAS9620771 
GO:0006091generation of precursor metabolites and energyTAS9620771 
GO:0007165signal transductionTAS9620771 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
GO:0005625soluble fractionTAS9620771 
GO:0030141secretory granuleIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG MELANOGENESIS 10280All SZGR 2.0 genes in this pathway
KEGG ADIPOCYTOKINE SIGNALING PATHWAY 6757All SZGR 2.0 genes in this pathway
PID REG GR PATHWAY 8260All SZGR 2.0 genes in this pathway
PID SYNDECAN 3 PATHWAY 1715All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D 3523All SZGR 2.0 genes in this pathway
REACTOME ANDROGEN BIOSYNTHESIS 108All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES 200136All SZGR 2.0 genes in this pathway
REACTOME BIOLOGICAL OXIDATIONS 13991All SZGR 2.0 genes in this pathway
REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE 5134All SZGR 2.0 genes in this pathway
REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS 7050All SZGR 2.0 genes in this pathway
REACTOME ENDOGENOUS STEROLS 1510All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920449All SZGR 2.0 genes in this pathway
REACTOME PEPTIDE LIGAND BINDING RECEPTORS 188108All SZGR 2.0 genes in this pathway
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS 305177All SZGR 2.0 genes in this pathway
REACTOME OPIOID SIGNALLING 7856All SZGR 2.0 genes in this pathway
REACTOME PEPTIDE HORMONE BIOSYNTHESIS 1410All SZGR 2.0 genes in this pathway
REACTOME G PROTEIN ACTIVATION 2715All SZGR 2.0 genes in this pathway
REACTOME STEROID HORMONES 2921All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING 805368All SZGR 2.0 genes in this pathway
REACTOME G ALPHA I SIGNALLING EVENTS 195114All SZGR 2.0 genes in this pathway
REACTOME G ALPHA S SIGNALLING EVENTS 12182All SZGR 2.0 genes in this pathway
REACTOME GPCR LIGAND BINDING 408246All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS 478302All SZGR 2.0 genes in this pathway
INGRAM SHH TARGETS UP 12779All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038678All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118744All SZGR 2.0 genes in this pathway
ABBUD LIF SIGNALING 1 UP 4629All SZGR 2.0 genes in this pathway
WANG LSD1 TARGETS DN 3930All SZGR 2.0 genes in this pathway
HANN RESISTANCE TO BCL2 INHIBITOR DN 4831All SZGR 2.0 genes in this pathway
MCGARVEY SILENCED BY METHYLATION IN COLON CANCER 4229All SZGR 2.0 genes in this pathway
HOFFMANN LARGE TO SMALL PRE BII LYMPHOCYTE DN 7247All SZGR 2.0 genes in this pathway
MIKKELSEN IPS HCP WITH H3 UNMETHYLATED 8050All SZGR 2.0 genes in this pathway