Gene Page: TOLLIP

Summary ?
GeneID54472
SymbolTOLLIP
SynonymsIL-1RAcPIP
Descriptiontoll interacting protein
ReferenceMIM:606277|HGNC:HGNC:16476|Ensembl:ENSG00000078902|HPRD:05887|Vega:OTTHUMG00000133333
Gene typeprotein-coding
Map location11p15.5
Pascal p-value0.09
Sherlock p-value0.443
Fetal beta-2.343
DMG2 (# studies)
SupportG2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS
CompositeSet

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Nishioka_2013Genome-wide DNA methylation analysisThe authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls. 5
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 5
ExpressionMeta-analysis of gene expressionP value: 1.416 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.1454 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg17676428111314042TOLLIP9.13E-60.4740.013DMG:Wockner_2014
cg11259409111331124LOC255512;TOLLIP9.04E-5-0.2250.027DMG:Wockner_2014
cg03101580111302893TOLLIP9.43E-50.6080.027DMG:Wockner_2014
cg26080154111314228TOLLIP2.4E-40.380.037DMG:Wockner_2014
cg13547299111330611TOLLIP-0.0280.49DMG:Nishioka_2013


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004871signal transducer activityNAS11441107 
GO:0005121Toll bindingNAS11441107 
GO:0005515protein bindingIPI10854325 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007267cell-cell signalingTAS10854325 
GO:0007242intracellular signaling cascadeNAS10854325 
GO:0006955immune responseIEA-
GO:0006954inflammatory responseNAS10854325 
GO:0016310phosphorylationIDA1085432 
GO:0045321leukocyte activationNAS11441107 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005737cytoplasmIC11441107 
GO:0045323interleukin-1 receptor complexNAS10854325 
GO:0045092interleukin-18 receptor complexNAS10854325 

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
DAZAP2KIAA0058 | MGC14319 | MGC766 | PRTBDAZ associated protein 2Two-hybridBioGRID16189514 
IL1R1CD121A | D2S1473 | IL-1R-alpha | IL1R | IL1RA | P80interleukin 1 receptor, type IAffinity Capture-WesternBioGRID10854325 
IL1RAPC3orf13 | FLJ37788 | IL-1RAcP | IL1R3interleukin 1 receptor accessory protein-HPRD,BioGRID10854325 
IRAK1IRAK | pelleinterleukin-1 receptor-associated kinase 1-HPRD,BioGRID10854325 
LDB1CLIM2 | NLILIM domain binding 1Two-hybridBioGRID16189514 
RBPMSHERMESRNA binding protein with multiple splicingTwo-hybridBioGRID16189514 
RHOXF2PEPP-2 | PEPP2 | THG1Rhox homeobox family, member 2Two-hybridBioGRID16189514 
SEPT1DIFF6 | LARP | MGC20394 | PNUTL3 | SEP1septin 1Two-hybridBioGRID16189514 
SETDB1ESET | KG1T | KIAA0067 | KMT1ESET domain, bifurcated 1Two-hybridBioGRID16169070 
TLR2CD282 | TIL4toll-like receptor 2-HPRD,BioGRID11751856 
TLR4ARMD10 | CD284 | TOLL | hTolltoll-like receptor 4-HPRD,BioGRID11751856 
TOLLIPFLJ33531 | IL-1RAcPIPtoll interacting proteinReconstituted ComplexBioGRID11751856 
TOM1FLJ33404target of myb1 (chicken)-HPRD,BioGRID14563850 
XRN2-5'-3' exoribonuclease 2Two-hybridBioGRID15231747 
ZBTB16PLZF | ZNF145zinc finger and BTB domain containing 16Two-hybridBioGRID16169070 
ZHX1-zinc fingers and homeoboxes 1Two-hybridBioGRID16169070 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG TOLL LIKE RECEPTOR SIGNALING PATHWAY 10288All SZGR 2.0 genes in this pathway
BIOCARTA GSK3 PATHWAY 2726All SZGR 2.0 genes in this pathway
BIOCARTA IL1R PATHWAY 3329All SZGR 2.0 genes in this pathway
BIOCARTA TOLL PATHWAY 3731All SZGR 2.0 genes in this pathway
PID IL1 PATHWAY 3428All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ILS 10786All SZGR 2.0 genes in this pathway
REACTOME IL1 SIGNALING 3930All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933616All SZGR 2.0 genes in this pathway
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM 270204All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 1 UP 380236All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 2 UP 418263All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP 1821933All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS UP 293179All SZGR 2.0 genes in this pathway
CREIGHTON AKT1 SIGNALING VIA MTOR UP 3422All SZGR 2.0 genes in this pathway
PEREZ TP53 TARGETS 1174695All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED 1022619All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER DN 540340All SZGR 2.0 genes in this pathway
LABBE WNT3A TARGETS DN 9753All SZGR 2.0 genes in this pathway
LABBE TARGETS OF TGFB1 AND WNT3A DN 10868All SZGR 2.0 genes in this pathway
NAKAMURA METASTASIS MODEL UP 4526All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE 1137655All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP 682433All SZGR 2.0 genes in this pathway
KUMAR PATHOGEN LOAD BY MACROPHAGES 275155All SZGR 2.0 genes in this pathway
ZWANG CLASS 1 TRANSIENTLY INDUCED BY EGF 516308All SZGR 2.0 genes in this pathway