Summary ?
GeneID54474
SymbolKRT20
SynonymsCD20|CK-20|CK20|K20|KRT21
Descriptionkeratin 20
ReferenceMIM:608218|HGNC:HGNC:20412|Ensembl:ENSG00000171431|HPRD:12193|Vega:OTTHUMG00000133366
Gene typeprotein-coding
Map location17q21.2
Pascal p-value0.801
TADA p-value0.01
Fetal beta0.3
SupportCompositeSet

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DNM:Fromer_2014Whole Exome Sequencing analysisThis study reported a WES study of 623 schizophrenia trios, reporting DNMs using genomic DNA.

Section I. Genetics and epigenetics annotation

@DNM table

GeneChromosomePositionRefAltTranscriptAA changeMutation typeSiftCG46TraitStudy
KRT20chr1739036479GANM_019010p.222T>ImissenseSchizophreniaDNM:Fromer_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ABI2ABI-2 | ABI2B | AIP-1 | AblBP3 | SSH3BP2 | argBPIA | argBPIBabl interactor 2Two-hybridBioGRID16189514 
AMOTL2LCCPangiomotin like 2Two-hybridBioGRID16189514 
ANKRD26L1MGC12538ankyrin repeat domain 26-like 1Two-hybridBioGRID16189514 
C9orf16EST00098 | FLJ12823 | MGC4639chromosome 9 open reading frame 16Two-hybridBioGRID16189514 
CCDC85BDIPAcoiled-coil domain containing 85BTwo-hybridBioGRID16189514 
COASYDPCK | FLJ35179 | NBP | PPAT | UKR1 | pOV-2Coenzyme A synthaseTwo-hybridBioGRID16189514 
EIF4E24E-LP | 4EHP | EIF4EL3 | IF4eeukaryotic translation initiation factor 4E family member 2Two-hybridBioGRID16189514 
EXOC8EXO84 | Exo84p | SEC84exocyst complex component 8Two-hybridBioGRID16189514 
FAM164CC14orf140 | FLJ23093family with sequence similarity 164, member CTwo-hybridBioGRID16189514 
FXR2FMR1L2fragile X mental retardation, autosomal homolog 2Two-hybridBioGRID16189514 
KRT15CK15 | K15 | K1COkeratin 15Two-hybridBioGRID16189514 
KRT20CD20 | CK20 | K20 | KRT21 | MGC35423keratin 20Two-hybridBioGRID16189514 
PRC1ASE1 | MGC1671 | MGC3669protein regulator of cytokinesis 1Two-hybridBioGRID16189514 
VIMFLJ36605vimentinTwo-hybridBioGRID16189514 
ZC3H14FLJ11806 | MGC26892 | NY-REN-37 | UKp68zinc finger CCCH-type containing 14Two-hybridBioGRID16189514 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
WATANABE RECTAL CANCER RADIOTHERAPY RESPONSIVE DN 9251All SZGR 2.0 genes in this pathway
WATANABE COLON CANCER MSI VS MSS DN 8142All SZGR 2.0 genes in this pathway
ZHONG RESPONSE TO AZACITIDINE AND TSA UP 183119All SZGR 2.0 genes in this pathway
LIU CDX2 TARGETS UP 3622All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 16521023All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442892All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK 779480All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 17Q11 Q21 AMPLICON 13378All SZGR 2.0 genes in this pathway
STONER ESOPHAGEAL CARCINOGENESIS UP 3925All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 3 720440All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER WITH H3K9ME3 UP 14175All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE 1137655All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP 682433All SZGR 2.0 genes in this pathway
VANLOO SP3 TARGETS DN 8947All SZGR 2.0 genes in this pathway