Summary ?
GeneID54476
SymbolRNF216
SynonymsCAHH|TRIAD3|U7I1|UBCE7IP1|ZIN
Descriptionring finger protein 216
ReferenceMIM:609948|HGNC:HGNC:21698|Ensembl:ENSG00000011275|HPRD:15550|Vega:OTTHUMG00000155500
Gene typeprotein-coding
Map location7p22.1
Pascal p-value0.085
Sherlock p-value0.361
DMG1 (# studies)
SupportAscano FMRP targets

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg1167423175821297RNF2163.806E-4-0.2540.043DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AGFG1DKFZp686I15205 | HRB | MGC116938 | MGC116940 | RAB | RIPArfGAP with FG repeats 1-HPRD11854271 
RIPK1FLJ39204 | RIP | RIP1receptor (TNFRSF)-interacting serine-threonine kinase 1-HPRD,BioGRID11854271 
RNF216TRIAD3 | U7I1 | UBCE7IP1 | ZINring finger protein 216Two-hybridBioGRID16169070 
TLR3CD283toll-like receptor 3-HPRD,BioGRID15107846 
TLR4ARMD10 | CD284 | TOLL | hTolltoll-like receptor 4-HPRD,BioGRID15107846 
TLR5FLJ10052 | MGC126430 | MGC126431 | SLEB1 | TIL3toll-like receptor 5-HPRD,BioGRID15107846 
TLR9CD289toll-like receptor 9-HPRD,BioGRID15107846 
UBE2CUBCH10 | dJ447F3.2ubiquitin-conjugating enzyme E2CAffinity Capture-WesternBioGRID15107846 
UBE2HE2-20K | UBC8 | UBCH | UBCH2ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)Affinity Capture-WesternBioGRID15107846 
UBE2L3E2-F1 | L-UBC | UBCH7 | UbcM4ubiquitin-conjugating enzyme E2L 3-HPRD,BioGRID15107846 
UBE2L6MGC40331 | RIG-B | UBCH8ubiquitin-conjugating enzyme E2L 6-HPRD,BioGRID15107846 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
OSMAN BLADDER CANCER DN 406230All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
GAVIN FOXP3 TARGETS CLUSTER P3 160103All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER LATE RECURRENCE UP 6242All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 19721213All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE EARLY LATE 317190All SZGR 2.0 genes in this pathway
ZWANG EGF PERSISTENTLY UP 3224All SZGR 2.0 genes in this pathway