Gene Page: POU1F1
Summary ?
| GeneID | 5449 |
| Symbol | POU1F1 |
| Synonyms | CPHD1|GHF-1|PIT1|POU1F1a|Pit-1 |
| Description | POU class 1 homeobox 1 |
| Reference | MIM:173110|HGNC:HGNC:9210|Ensembl:ENSG00000064835|HPRD:01409|Vega:OTTHUMG00000158992 |
| Gene type | protein-coding |
| Map location | 3p11 |
| Pascal p-value | 0.049 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| GSMA_IIA | Genome scan meta-analysis (All samples) | Psr: 0.04047 | |
| GSMA_IIE | Genome scan meta-analysis (European-ancestry samples) | Psr: 0.04359 |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| UBE2V2 | 0.92 | 0.91 |
| ZC3H15 | 0.92 | 0.91 |
| DNAJA2 | 0.91 | 0.89 |
| DNM1L | 0.89 | 0.87 |
| UCHL5 | 0.88 | 0.88 |
| CUL2 | 0.88 | 0.86 |
| MORF4L2 | 0.88 | 0.86 |
| BTBD10 | 0.88 | 0.86 |
| UBE2K | 0.88 | 0.88 |
| PPP2CA | 0.87 | 0.86 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| MT-CO2 | -0.66 | -0.60 |
| AF347015.2 | -0.66 | -0.58 |
| FXYD1 | -0.64 | -0.61 |
| AF347015.26 | -0.64 | -0.56 |
| AF347015.8 | -0.64 | -0.58 |
| AF347015.31 | -0.63 | -0.59 |
| AF347015.33 | -0.63 | -0.58 |
| MT-CYB | -0.63 | -0.57 |
| AF347015.21 | -0.62 | -0.50 |
| HIGD1B | -0.62 | -0.58 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0003700 | transcription factor activity | TAS | 1487156 |9482665 | |
| GO:0043565 | sequence-specific DNA binding | IEA | - | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | - | |
| GO:0006366 | transcription from RNA polymerase II promoter | TAS | 1487156 | |
| GO:0009887 | organ morphogenesis | TAS | 9482665 | |
| GO:0008285 | negative regulation of cell proliferation | TAS | 9392392 | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005634 | nucleus | IEA | - |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| PID REG GR PATHWAY | 82 | 60 | All SZGR 2.0 genes in this pathway |
| HEIDENBLAD AMPLIFIED IN SOFT TISSUE CANCER | 13 | 7 | All SZGR 2.0 genes in this pathway |
| PUJANA ATM PCC NETWORK | 1442 | 892 | All SZGR 2.0 genes in this pathway |
| PARK HSC AND MULTIPOTENT PROGENITORS | 50 | 33 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 48HR UP | 180 | 125 | All SZGR 2.0 genes in this pathway |
| MARTINEZ RB1 TARGETS DN | 543 | 317 | All SZGR 2.0 genes in this pathway |
| MARTINEZ TP53 TARGETS DN | 593 | 372 | All SZGR 2.0 genes in this pathway |
| MARTINEZ RB1 AND TP53 TARGETS DN | 591 | 366 | All SZGR 2.0 genes in this pathway |
| MATZUK CENTRAL FOR FEMALE FERTILITY | 29 | 25 | All SZGR 2.0 genes in this pathway |
| YOSHIMURA MAPK8 TARGETS UP | 1305 | 895 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 1HR UP | 61 | 44 | All SZGR 2.0 genes in this pathway |
| RAO BOUND BY SALL4 ISOFORM A | 182 | 108 | All SZGR 2.0 genes in this pathway |
| ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY | 1839 | 928 | All SZGR 2.0 genes in this pathway |