SZGR2

Summary ?

GeneID	545
Symbol	ATR
Synonyms	FCTCS\|FRP1\|MEC1\|SCKL\|SCKL1
Description	ATR serine/threonine kinase
Reference	MIM:601215\|HGNC:HGNC:882\|Ensembl:ENSG00000175054\|HPRD:08369\|Vega:OTTHUMG00000159234
Gene type	protein-coding
Map location	3q23
Pascal p-value	0.799
Fetal beta	-0.454
eGene	Myers' cis & trans
Support	Ascano FMRP targets

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	Click to show details

Section I. Genetics and epigenetics annotation

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	qvalue	eQTL type
rs4491879	chr3	189373908	ATR	545	0.05	trans
rs4505678	chr3	189374356	ATR	545	0.06	trans
rs16894557	chr6	28999825	ATR	545	0	trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ABL1	ABL \| JTK7 \| bcr/abl \| c-ABL \| p150 \| v-abl	c-abl oncogene 1, receptor tyrosine kinase	Protein-peptide	BioGRID	10608806
AP1B1	ADTB1 \| AP105A \| BAM22 \| CLAPB2	adaptor-related protein complex 1, beta 1 subunit	Protein-peptide	BioGRID	10608806
AP2A2	ADTAB \| CLAPA2 \| HIP9 \| HYPJ	adaptor-related protein complex 2, alpha 2 subunit	Protein-peptide	BioGRID	10608806
ARHGEF1	GEF1 \| LBCL2 \| LSC \| P115-RHOGEF \| SUB1.5	Rho guanine nucleotide exchange factor (GEF) 1	Protein-peptide	BioGRID	10608806
ATM	AT1 \| ATA \| ATC \| ATD \| ATDC \| ATE \| DKFZp781A0353 \| MGC74674 \| TEL1 \| TELO1	ataxia telangiectasia mutated	Protein-peptide	BioGRID	10608806
ATMIN	ASCIZ \| DKFZp779K1455 \| FLJ76795 \| KIAA0431 \| ZNF822	ATM interactor	ATR interacts with ASCIZ. This interaction was modeled on a demonstrated interaction between yeast ATR and human ASCIZ.	BIND	15933716
ATR	FRP1 \| MEC1 \| SCKL \| SCKL1	ataxia telangiectasia and Rad3 related	Protein-peptide	BioGRID	10608806
ATRIP	DKFZp762J2115 \| FLJ12343 \| MGC20625 \| MGC21482 \| MGC26740	ATR interacting protein	Affinity Capture-MS Affinity Capture-Western Biochemical Activity	BioGRID	11721054 \|14657349 \|15210935
BRCA1	BRCAI \| BRCC1 \| IRIS \| PSCP \| RNF53	breast cancer 1, early onset	BRCA1 physically and functionally interacts with ATR during genotoxic stress	BIND	11016625 \|11278964
BRCA1	BRCAI \| BRCC1 \| IRIS \| PSCP \| RNF53	breast cancer 1, early onset	Affinity Capture-Western Protein-peptide Reconstituted Complex	BioGRID	10608806 \|11016625 \|11114888 \|11278964
BRCA2	BRCC2 \| FACD \| FAD \| FAD1 \| FANCB \| FANCD \| FANCD1	breast cancer 2, early onset	Protein-peptide	BioGRID	10608806
CHD4	DKFZp686E06161 \| Mi-2b \| Mi2-BETA	chromodomain helicase DNA binding protein 4	-	HPRD,BioGRID	10545197
CHEK1	CHK1	CHK1 checkpoint homolog (S. pombe)	Protein-peptide	BioGRID	10608806
CHEK1	CHK1	CHK1 checkpoint homolog (S. pombe)	ATR interacts with CHEK1 (CHK1).	BIND	15775976
CLSPN	CLASPIN \| MGC131612 \| MGC131613 \| MGC131615	claspin homolog (Xenopus laevis)	-	HPRD,BioGRID	12766152
E4F1	E4F \| MGC99614	E4F transcription factor 1	Protein-peptide	BioGRID	10608806
EEF1E1	AIMP3 \| P18	eukaryotic translation elongation factor 1 epsilon 1	p18 interacts with ATR.	BIND	15680327
HDAC1	DKFZp686H12203 \| GON-10 \| HD1 \| RPD3 \| RPD3L1	histone deacetylase 1	Affinity Capture-Western	BioGRID	10545197
HDAC2	RPD3 \| YAF1	histone deacetylase 2	Affinity Capture-Western Co-purification	BioGRID	10545197
LIG4	-	ligase IV, DNA, ATP-dependent	Protein-peptide	BioGRID	10608806
MCM2	BM28 \| CCNL1 \| CDCL1 \| D3S3194 \| KIAA0030 \| MGC10606 \| MITOTIN \| cdc19	minichromosome maintenance complex component 2	Biochemical Activity	BioGRID	15210935
MCM7	CDABP0042 \| CDC47 \| MCM2 \| P1.1-MCM3 \| P1CDC47 \| P85MCM \| PNAS-146	minichromosome maintenance complex component 7	Affinity Capture-Western	BioGRID	15210935
MRE11A	ATLD \| HNGS1 \| MRE11 \| MRE11B	MRE11 meiotic recombination 11 homolog A (S. cerevisiae)	Protein-peptide	BioGRID	10608806
MSH2	COCA1 \| FCC1 \| HNPCC \| HNPCC1 \| LCFS2	mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)	-	HPRD,BioGRID	14657349
MTA1	-	metastasis associated 1	Affinity Capture-Western	BioGRID	10545197
MTA2	DKFZp686F2281 \| MTA1L1 \| PID	metastasis associated 1 family, member 2	Affinity Capture-Western	BioGRID	10545197
NBN	AT-V1 \| AT-V2 \| ATV \| FLJ10155 \| MGC87362 \| NBS \| NBS1 \| P95	nibrin	Protein-peptide	BioGRID	10608806
NBN	AT-V1 \| AT-V2 \| ATV \| FLJ10155 \| MGC87362 \| NBS \| NBS1 \| P95	nibrin	NBS1 interacts with ATR.	BIND	15758953
PA2G4	EBP1 \| HG4-1 \| p38-2G4	proliferation-associated 2G4, 38kDa	Protein-peptide	BioGRID	10608806
PIK3CA	MGC142161 \| MGC142163 \| PI3K \| p110-alpha	phosphoinositide-3-kinase, catalytic, alpha polypeptide	Protein-peptide	BioGRID	10608806
PML	MYL \| PP8675 \| RNF71 \| TRIM19	promyelocytic leukemia	ATR phosphorylates PML.	BIND	15195100
POLD1	CDC2 \| POLD	polymerase (DNA directed), delta 1, catalytic subunit 125kDa	Protein-peptide	BioGRID	10608806
PPP2R2A	B55-ALPHA \| B55A \| FLJ26613 \| MGC52248 \| PR52A \| PR55A	protein phosphatase 2 (formerly 2A), regulatory subunit B, alpha isoform	Protein-peptide	BioGRID	10608806
PTS	FLJ97081 \| PTPS	6-pyruvoyltetrahydropterin synthase	Protein-peptide	BioGRID	10608806
RAD17	CCYC \| FLJ41520 \| HRAD17 \| R24L \| RAD17SP \| RAD24	RAD17 homolog (S. pombe)	Affinity Capture-Western Biochemical Activity Protein-peptide	BioGRID	10608806 \|11418864
RHEB	MGC111559 \| RHEB2	Ras homolog enriched in brain	ATR interacts with Rheb.	BIND	15854902
RHEB	MGC111559 \| RHEB2	Ras homolog enriched in brain	Affinity Capture-Western Reconstituted Complex	BioGRID	15854902
RPA1	HSSB \| REPA1 \| RF-A \| RP-A \| RPA70	replication protein A1, 70kDa	Protein-peptide	BioGRID	10608806
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	ATR interacts with TP53 (p53).	BIND	15775976
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	Protein-peptide Reconstituted Complex	BioGRID	10608806 \|15159397
TREX1	AGS1 \| AGS5 \| CRV \| DKFZp434J0310 \| DRN3 \| HERNS	three prime repair exonuclease 1	-	HPRD	11721054
WRN	DKFZp686C2056 \| RECQ3 \| RECQL2 \| RECQL3	Werner syndrome	Protein-peptide	BioGRID	10608806
XRCC5	FLJ39089 \| KARP-1 \| KARP1 \| KU80 \| KUB2 \| Ku86 \| NFIV	X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)	XRCC5 (Ku80) interacts with ATR.	BIND	15758953

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG CELL CYCLE	128	84	All SZGR 2.0 genes in this pathway
KEGG P53 SIGNALING PATHWAY	69	45	All SZGR 2.0 genes in this pathway
BIOCARTA G1 PATHWAY	28	21	All SZGR 2.0 genes in this pathway
BIOCARTA G2 PATHWAY	24	20	All SZGR 2.0 genes in this pathway
BIOCARTA ATRBRCA PATHWAY	21	12	All SZGR 2.0 genes in this pathway
PID FANCONI PATHWAY	47	28	All SZGR 2.0 genes in this pathway
PID ATR PATHWAY	39	25	All SZGR 2.0 genes in this pathway
PID TCPTP PATHWAY	43	33	All SZGR 2.0 genes in this pathway
PID CIRCADIAN PATHWAY	16	15	All SZGR 2.0 genes in this pathway
PID BARD1 PATHWAY	29	19	All SZGR 2.0 genes in this pathway
PID P53 REGULATION PATHWAY	59	50	All SZGR 2.0 genes in this pathway
REACTOME MEIOSIS	116	81	All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE	421	253	All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE CHECKPOINTS	124	70	All SZGR 2.0 genes in this pathway
REACTOME FANCONI ANEMIA PATHWAY	25	11	All SZGR 2.0 genes in this pathway
REACTOME DNA REPAIR	112	59	All SZGR 2.0 genes in this pathway
REACTOME CHROMOSOME MAINTENANCE	122	80	All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS	38	18	All SZGR 2.0 genes in this pathway
REACTOME MEIOTIC SYNAPSIS	73	57	All SZGR 2.0 genes in this pathway
REACTOME G2 M CHECKPOINTS	45	23	All SZGR 2.0 genes in this pathway
REACTOME G2 M DNA DAMAGE CHECKPOINT	12	8	All SZGR 2.0 genes in this pathway
LIU SOX4 TARGETS UP	137	94	All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS DN	431	263	All SZGR 2.0 genes in this pathway
HOEBEKE LYMPHOID STEM CELL UP	95	64	All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP	1278	748	All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN	1375	806	All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED UP	633	376	All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC UP	722	443	All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN	485	334	All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL UP	584	356	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN	855	609	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 COMMON DN	483	336	All SZGR 2.0 genes in this pathway
PUJANA BREAST CANCER LIT INT NETWORK	101	73	All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK	1652	1023	All SZGR 2.0 genes in this pathway
PUJANA BRCA2 PCC NETWORK	423	265	All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK	779	480	All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS DN	637	377	All SZGR 2.0 genes in this pathway
KAUFFMANN DNA REPAIR GENES	230	137	All SZGR 2.0 genes in this pathway
PENG GLUTAMINE DEPRIVATION DN	337	230	All SZGR 2.0 genes in this pathway
FLECHNER PBL KIDNEY TRANSPLANT REJECTED VS OK UP	63	48	All SZGR 2.0 genes in this pathway
HADDAD B LYMPHOCYTE PROGENITOR	293	193	All SZGR 2.0 genes in this pathway
GALE APL WITH FLT3 MUTATED UP	56	35	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN	1237	837	All SZGR 2.0 genes in this pathway
WEIGEL OXIDATIVE STRESS BY HNE AND TBH	60	42	All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION DN	287	208	All SZGR 2.0 genes in this pathway
LY AGING OLD DN	56	35	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR UP	953	554	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR DN	1011	592	All SZGR 2.0 genes in this pathway
ZHANG BREAST CANCER PROGENITORS UP	425	253	All SZGR 2.0 genes in this pathway
EHLERS ANEUPLOIDY UP	41	29	All SZGR 2.0 genes in this pathway
FIRESTEIN PROLIFERATION	175	125	All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS UP	518	299	All SZGR 2.0 genes in this pathway
FONTAINE FOLLICULAR THYROID ADENOMA DN	68	45	All SZGR 2.0 genes in this pathway
FONTAINE THYROID TUMOR UNCERTAIN MALIGNANCY DN	26	14	All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN	918	550	All SZGR 2.0 genes in this pathway

Gene Page: ATR