Summary ?
GeneID54550
SymbolNECAB2
SynonymsEFCBP2
DescriptionN-terminal EF-hand calcium binding protein 2
ReferenceHGNC:HGNC:23746|Ensembl:ENSG00000103154|HPRD:13263|Vega:OTTHUMG00000137636
Gene typeprotein-coding
Map location16q23.3
Pascal p-value0.248
Sherlock p-value0.894
Fetal beta-2.481
DMG1 (# studies)
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg000216001684003607NECAB22.806E-40.8560.039DMG:Wockner_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs17542055chr742652803NECAB2545500.15trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CAPN3CANP3 | CANPL3 | LGMD2 | LGMD2A | MGC10767 | MGC11121 | MGC14344 | MGC4403 | nCL-1 | p94calpain 3, (p94)Two-hybridBioGRID16189514 
CCDC33FLJ23168 | FLJ32855 | MGC34145coiled-coil domain containing 33Two-hybridBioGRID16189514 
CCNKCPR4 | MGC9113cyclin KTwo-hybridBioGRID16189514 
CENPOCENP-O | MGC11266centromere protein OTwo-hybridBioGRID16189514 
DFFADFF-45 | DFF1 | ICADDNA fragmentation factor, 45kDa, alpha polypeptideTwo-hybridBioGRID16189514 
DGCR6LFLJ10666DiGeorge syndrome critical region gene 6-likeTwo-hybridBioGRID16189514 
FXR2FMR1L2fragile X mental retardation, autosomal homolog 2Two-hybridBioGRID16189514 
GTPBP10DKFZp686A10121 | FLJ38242 | MGC104191 | ObgH2 | UG0751c10GTP-binding protein 10 (putative)Two-hybridBioGRID16189514 
KIAA1267DKFZp686P06109 | DKFZp727C091 | MGC102843KIAA1267Two-hybridBioGRID16189514 
LNX1LNX | MPDZ | PDZRN2ligand of numb-protein X 1Two-hybridBioGRID16189514 
NECAB2EFCBP2N-terminal EF-hand calcium binding protein 2Affinity Capture-Western
Two-hybrid
BioGRID16189514 
NEK6SID6-1512NIMA (never in mitosis gene a)-related kinase 6Two-hybridBioGRID16189514 
NOC4LMGC3162 | NOC4nucleolar complex associated 4 homolog (S. cerevisiae)Two-hybridBioGRID16189514 
PSMA1HC2 | MGC14542 | MGC14575 | MGC14751 | MGC1667 | MGC21459 | MGC22853 | MGC23915 | NU | PROS30proteasome (prosome, macropain) subunit, alpha type, 1Two-hybridBioGRID16189514 
RCOR3FLJ10876 | FLJ16298 | RP11-318L16.1REST corepressor 3Two-hybridBioGRID16189514 
RUNX1T1AML1T1 | CBFA2T1 | CDR | ETO | MGC2796 | MTG8 | MTG8b | ZMYND2runt-related transcription factor 1; translocated to, 1 (cyclin D-related)Two-hybridBioGRID16189514 
TEX11TGC1 | TSGA3testis expressed 11Two-hybridBioGRID16189514 
VTA1C6orf55 | DRG-1 | DRG1 | FLJ27228 | HSPC228 | LIP5 | My012 | SBP1Vps20-associated 1 homolog (S. cerevisiae)Two-hybridBioGRID16189514 
WDYHV1C8orf32 | FLJ10204WDYHV motif containing 1Two-hybridBioGRID16189514 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP 552347All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND SERUM DEPRIVATION UP 211136All SZGR 2.0 genes in this pathway
KOYAMA SEMA3B TARGETS DN 411249All SZGR 2.0 genes in this pathway
LEIN LOCALIZED TO PROXIMAL DENDRITES 3726All SZGR 2.0 genes in this pathway
LEE LIVER CANCER SURVIVAL UP 185112All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS PROLIFERATION DN 17997All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME2 491319All SZGR 2.0 genes in this pathway
MIKKELSEN MCV6 HCP WITH H3K27ME3 435318All SZGR 2.0 genes in this pathway
MIKKELSEN MEF HCP WITH H3K27ME3 590403All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP 756494All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP 682440All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS CALB1 CORR UP 548370All SZGR 2.0 genes in this pathway
HOELZEL NF1 TARGETS DN 11573All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP A 898516All SZGR 2.0 genes in this pathway