SZGR2

Summary ?

GeneID	5465
Symbol	PPARA
Synonyms	NR1C1\|PPAR\|PPARalpha\|hPPAR
Description	peroxisome proliferator activated receptor alpha
Reference	MIM:170998\|HGNC:HGNC:9232\|Ensembl:ENSG00000186951\|HPRD:01369\|Vega:OTTHUMG00000150443
Gene type	protein-coding
Map location	22q13.31
Pascal p-value	0.473
Fetal beta	0.203
eGene	Meta

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias	Click to show details

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0004872	receptor activity	IEA		-
GO:0004879	ligand-dependent nuclear receptor activity	IEA		-
GO:0003700	transcription factor activity	IEA		-
GO:0003707	steroid hormone receptor activity	IEA		-
GO:0005515	protein binding	IPI		12039952 \|16554032
GO:0008270	zinc ion binding	IEA		-
GO:0008144	drug binding	IDA		9113987
GO:0016563	transcription activator activity	IEA		-
GO:0046872	metal ion binding	IEA		-
GO:0043565	sequence-specific DNA binding	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0006355	regulation of transcription, DNA-dependent	IEA		-
GO:0006350	transcription	IEA		-
GO:0008544	epidermis development	IEA		-
GO:0006629	lipid metabolic process	TAS		7684926 \|9792666
GO:0015908	fatty acid transport	TAS		16271724
GO:0019217	regulation of fatty acid metabolic process	IEA		-
GO:0032000	positive regulation of fatty acid beta-oxidation	TAS		16271724
GO:0045941	positive regulation of transcription	IEA		-
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005634	nucleus	IEA		-
GO:0005634	nucleus	TAS		16271724

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
AIP	ARA9 \| FKBP16 \| FKBP37 \| SMTPHN \| XAP2	aryl hydrocarbon receptor interacting protein	-	HPRD,BioGRID	12482853
AKAP13	AKAP-Lbc \| BRX \| FLJ11952 \| FLJ43341 \| HA-3 \| Ht31 \| LBC \| PROTO-LB \| PROTO-LBC \| c-lbc	A kinase (PRKA) anchor protein 13	-	HPRD,BioGRID	9627117
CEP350	CAP350 \| FLJ38282 \| FLJ44058 \| GM133 \| KIAA0480	centrosomal protein 350kDa	CAP350 interacts with PPAR-alpha.	BIND	15615782
DAP3	DAP-3 \| DKFZp686G12159 \| MGC126058 \| MGC126059 \| MRP-S29 \| MRPS29 \| bMRP-10	death associated protein 3	-	HPRD,BioGRID	10903152
DUT	FLJ20622 \| dUTPase	deoxyuridine triphosphatase	-	HPRD	8910358
EP300	KAT3B \| p300	E1A binding protein p300	-	HPRD,BioGRID	9407140
FABP1	FABPL \| L-FABP	fatty acid binding protein 1, liver	-	HPRD,BioGRID	11226238
GADD45A	DDIT1 \| GADD45	growth arrest and DNA-damage-inducible, alpha	-	HPRD	10872826
GADD45B	DKFZp566B133 \| GADD45BETA \| MYD118	growth arrest and DNA-damage-inducible, beta	-	HPRD	10872826
GADD45G	CR6 \| DDIT2 \| GADD45gamma \| GRP17	growth arrest and DNA-damage-inducible, gamma	-	HPRD,BioGRID	10872826
HSP90AA1	FLJ31884 \| HSP86 \| HSP89A \| HSP90A \| HSP90N \| HSPC1 \| HSPCA \| HSPCAL1 \| HSPCAL4 \| HSPN \| Hsp89 \| Hsp90 \| LAP2	heat shock protein 90kDa alpha (cytosolic), class A member 1	-	HPRD,BioGRID	12482853
MECR	CGI-63 \| FASN2B \| NRBF1	mitochondrial trans-2-enoyl-CoA reductase	-	HPRD,BioGRID	9795230
MED1	CRSP1 \| CRSP200 \| DRIP205 \| DRIP230 \| MGC71488 \| PBP \| PPARBP \| PPARGBP \| RB18A \| TRAP220 \| TRIP2	mediator complex subunit 1	-	HPRD	9653119
MED24	ARC100 \| CRSP100 \| CRSP4 \| DRIP100 \| KIAA0130 \| MGC8748 \| THRAP4 \| TRAP100	mediator complex subunit 24	-	HPRD,BioGRID	9653119
NCOA1	F-SRC-1 \| KAT13A \| MGC129719 \| MGC129720 \| NCoA-1 \| RIP160 \| SRC-1 \| SRC1 \| bHLHe42	nuclear receptor coactivator 1	-	HPRD,BioGRID	9407140
NCOA3	ACTR \| AIB-1 \| AIB1 \| CAGH16 \| CTG26 \| KAT13B \| MGC141848 \| RAC3 \| SRC3 \| TNRC14 \| TNRC16 \| TRAM-1 \| pCIP	nuclear receptor coactivator 3	RAC3 interacts with PPAR-alpha. This interaction was modelled on a demonstrated interaction between human RAC3 and mouse PPAR-alpha.	BIND	9238002
NCOA6	AIB3 \| ANTP \| ASC2 \| HOX1.1 \| HOXA7 \| KIAA0181 \| NRC \| PRIP \| RAP250 \| TRBP	nuclear receptor coactivator 6	Two-hybrid	BioGRID	11158331
NCOR1	KIAA1047 \| MGC104216 \| N-CoR \| TRAC1 \| hCIT529I10 \| hN-CoR	nuclear receptor co-repressor 1	-	HPRD,BioGRID	10336495
NCOR2	CTG26 \| SMRT \| SMRTE \| SMRTE-tau \| TNRC14 \| TRAC-1 \| TRAC1	nuclear receptor co-repressor 2	-	HPRD,BioGRID	11845213
NR1H3	LXR-a \| LXRA \| RLD-1	nuclear receptor subfamily 1, group H, member 3	-	HPRD,BioGRID	8621574
NRBF2	COPR1 \| COPR2 \| DKFZp564C1664 \| FLJ30395 \| NRBF-2	nuclear receptor binding factor 2	-	HPRD,BioGRID	10786636
NRIP1	FLJ77253 \| RIP140	nuclear receptor interacting protein 1	-	HPRD,BioGRID	9626662 \|10022764
POU1F1	GHF-1 \| PIT1 \| Pit-1	POU class 1 homeobox 1	Reconstituted Complex	BioGRID	11891224
PPARGC1A	LEM6 \| PGC-1(alpha) \| PGC-1v \| PGC1 \| PGC1A \| PPARGC1	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	-	HPRD,BioGRID	10669761
PPARGC1B	ERRL1 \| PERC \| PGC-1(beta) \| PGC1B	peroxisome proliferator-activated receptor gamma, coactivator 1 beta	Reconstituted Complex	BioGRID	11733490
PRIC285	FLJ00244 \| KIAA1769 \| MGC132634 \| MGC138228 \| PDIP-1	peroxisomal proliferator-activated receptor A interacting complex 285	-	HPRD,BioGRID	12189208
RELA	MGC131774 \| NFKB3 \| p65	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	-	HPRD,BioGRID	10542237
RXRA	FLJ00280 \| FLJ00318 \| FLJ16020 \| FLJ16733 \| MGC102720 \| NR2B1	retinoid X receptor, alpha	-	HPRD,BioGRID	10195690
RXRG	NR2B3 \| RXRC	retinoid X receptor, gamma	Two-hybrid	BioGRID	16169070
STAC3	MGC2793	SH3 and cysteine rich domain 3	Two-hybrid	BioGRID	16189514

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG PPAR SIGNALING PATHWAY	69	47	All SZGR 2.0 genes in this pathway
KEGG ADIPOCYTOKINE SIGNALING PATHWAY	67	57	All SZGR 2.0 genes in this pathway
BIOCARTA PPARA PATHWAY	58	43	All SZGR 2.0 genes in this pathway
BIOCARTA NUCLEARRS PATHWAY	15	12	All SZGR 2.0 genes in this pathway
BIOCARTA PGC1A PATHWAY	26	20	All SZGR 2.0 genes in this pathway
BIOCARTA BARRESTIN PATHWAY	10	8	All SZGR 2.0 genes in this pathway
BIOCARTA TOLL PATHWAY	37	31	All SZGR 2.0 genes in this pathway
PID RXR VDR PATHWAY	26	24	All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY	396	292	All SZGR 2.0 genes in this pathway
REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION	36	27	All SZGR 2.0 genes in this pathway
REACTOME PPARA ACTIVATES GENE EXPRESSION	104	72	All SZGR 2.0 genes in this pathway
REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION	24	17	All SZGR 2.0 genes in this pathway
REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	24	16	All SZGR 2.0 genes in this pathway
REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	23	16	All SZGR 2.0 genes in this pathway
REACTOME GENERIC TRANSCRIPTION PATHWAY	352	181	All SZGR 2.0 genes in this pathway
REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	49	36	All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS	478	302	All SZGR 2.0 genes in this pathway
REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM	168	115	All SZGR 2.0 genes in this pathway
REACTOME CIRCADIAN CLOCK	53	40	All SZGR 2.0 genes in this pathway
REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	72	53	All SZGR 2.0 genes in this pathway
PARENT MTOR SIGNALING UP	567	375	All SZGR 2.0 genes in this pathway
NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL DN	634	384	All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS UP	473	314	All SZGR 2.0 genes in this pathway
SENESE HDAC1 AND HDAC2 TARGETS UP	238	144	All SZGR 2.0 genes in this pathway
RIZ ERYTHROID DIFFERENTIATION 6HR	40	23	All SZGR 2.0 genes in this pathway
RODRIGUES NTN1 AND DCC TARGETS	35	25	All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL AND BRAIN QTL TRANS	185	114	All SZGR 2.0 genes in this pathway
UEDA PERIFERAL CLOCK	169	111	All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS DN	366	238	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 20HR UP	240	152	All SZGR 2.0 genes in this pathway
NATSUME RESPONSE TO INTERFERON BETA UP	71	49	All SZGR 2.0 genes in this pathway
KEEN RESPONSE TO ROSIGLITAZONE UP	38	23	All SZGR 2.0 genes in this pathway
MAHAJAN RESPONSE TO IL1A UP	81	52	All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 3	720	440	All SZGR 2.0 genes in this pathway
BOCHKIS FOXA2 TARGETS	425	261	All SZGR 2.0 genes in this pathway
WINTER HYPOXIA METAGENE	242	168	All SZGR 2.0 genes in this pathway
FIRESTEIN PROLIFERATION	175	125	All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP	1305	895	All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3	1069	729	All SZGR 2.0 genes in this pathway
ROME INSULIN TARGETS IN MUSCLE UP	442	263	All SZGR 2.0 genes in this pathway
WOO LIVER CANCER RECURRENCE DN	80	54	All SZGR 2.0 genes in this pathway
CAIRO LIVER DEVELOPMENT DN	222	141	All SZGR 2.0 genes in this pathway
KYNG NORMAL AGING DN	30	13	All SZGR 2.0 genes in this pathway
KYNG WERNER SYNDROM DN	29	14	All SZGR 2.0 genes in this pathway
GABRIELY MIR21 TARGETS	289	187	All SZGR 2.0 genes in this pathway
MIYAGAWA TARGETS OF EWSR1 ETS FUSIONS UP	259	159	All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN	1080	713	All SZGR 2.0 genes in this pathway
PEDRIOLI MIR31 TARGETS DN	418	245	All SZGR 2.0 genes in this pathway
CHEMELLO SOLEUS VS EDL MYOFIBERS UP	35	16	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
let-7/98	7027	7033	1A	hsa-let-7a^brain	UGAGGUAGUAGGUUGUAUAGUU
				hsa-let-7b^brain	UGAGGUAGUAGGUUGUGUGGUU
				hsa-let-7c^brain	UGAGGUAGUAGGUUGUAUGGUU
				hsa-let-7d^brain	AGAGGUAGUAGGUUGCAUAGU
				hsa-let-7e^brain	UGAGGUAGGAGGUUGUAUAGU
				hsa-let-7f^brain	UGAGGUAGUAGAUUGUAUAGUU
				hsa-miR-98^brain	UGAGGUAGUAAGUUGUAUUGUU
				hsa-let-7g^SZ	UGAGGUAGUAGUUUGUACAGU
				hsa-let-7i^brain	UGAGGUAGUAGUUUGUGCUGU
miR-10	8322	8328	1A	hsa-miR-10a	UACCCUGUAGAUCCGAAUUUGUG
miR-10	8322	8328	1A	hsa-miR-10b	UACCCUGUAGAACCGAAUUUGU
miR-124.1	8335	8342	1A,m8	hsa-miR-124a	UUAAGGCACGCGGUGAAUGCCA
miR-124/506	8335	8341	1A	hsa-miR-506	UAAGGCACCCUUCUGAGUAGA
miR-124/506	8335	8341	1A	hsa-miR-124^brain	UAAGGCACGCGGUGAAUGCC
miR-128	7150	7156	1A	hsa-miR-128a	UCACAGUGAACCGGUCUCUUUU
miR-128	7150	7156	1A	hsa-miR-128b	UCACAGUGAACCGGUCUCUUUC
miR-144	7148	7154	m8	hsa-miR-144	UACAGUAUAGAUGAUGUACUAG
miR-17-5p/20/93.mr/106/519.d	416	422	m8	hsa-miR-17-5p	CAAAGUGCUUACAGUGCAGGUAGU
				hsa-miR-20a^brain	UAAAGUGCUUAUAGUGCAGGUAG
				hsa-miR-106a	AAAAGUGCUUACAGUGCAGGUAGC
				hsa-miR-106b^SZ	UAAAGUGCUGACAGUGCAGAU
				hsa-miR-20b^SZ	CAAAGUGCUCAUAGUGCAGGUAG
				hsa-miR-519d	CAAAGUGCCUCCCUUUAGAGUGU
miR-181	8302	8309	1A,m8	hsa-miR-181a^brain	AACAUUCAACGCUGUCGGUGAGU
				hsa-miR-181b^SZ	AACAUUCAUUGCUGUCGGUGGG
				hsa-miR-181c^brain	AACAUUCAACCUGUCGGUGAGU
				hsa-miR-181d^brain	AACAUUCAUUGUUGUCGGUGGGUU
miR-19	80	87	1A,m8	hsa-miR-19a	UGUGCAAAUCUAUGCAAAACUGA
miR-19	80	87	1A,m8	hsa-miR-19b	UGUGCAAAUCCAUGCAAAACUGA
miR-21	898	905	1A,m8	hsa-miR-21^brain	UAGCUUAUCAGACUGAUGUUGA
miR-21	898	905	1A,m8	hsa-miR-590	GAGCUUAUUCAUAAAAGUGCAG
miR-22	1217	1223	m8	hsa-miR-22^brain	AAGCUGCCAGUUGAAGAACUGU
miR-27	7150	7156	m8	hsa-miR-27a^brain	UUCACAGUGGCUAAGUUCCGC
miR-27	7150	7156	m8	hsa-miR-27b^brain	UUCACAGUGGCUAAGUUCUGC
miR-9	7624	7631	1A,m8	hsa-miR-9^SZ	UCUUUGGUUAUCUAGCUGUAUGA

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: PPARA