Gene Page: PPEF2
Summary ?
| GeneID | 5470 |
| Symbol | PPEF2 |
| Synonyms | PPP7CB |
| Description | protein phosphatase with EF-hand domain 2 |
| Reference | MIM:602256|HGNC:HGNC:9244|Ensembl:ENSG00000156194|HPRD:03771|Vega:OTTHUMG00000160915 |
| Gene type | protein-coding |
| Map location | 4q21.1 |
| Pascal p-value | 0.127 |
| Fetal beta | 0.86 |
| eGene | Cerebellar Hemisphere Cerebellum |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| DMKN | 0.82 | 0.35 |
| GOLT1A | 0.75 | 0.60 |
| BATF | 0.71 | 0.34 |
| C20orf27 | 0.70 | 0.54 |
| TMEM90A | 0.70 | 0.52 |
| RGS14 | 0.69 | 0.67 |
| TAC1 | 0.69 | 0.73 |
| AP003108.2 | 0.69 | 0.50 |
| TMEM45A | 0.69 | 0.33 |
| RGS9 | 0.68 | 0.34 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AC016910.1 | -0.29 | -0.27 |
| FAM13A | -0.27 | -0.27 |
| ZEB2 | -0.26 | -0.37 |
| ZNF238 | -0.26 | -0.20 |
| DPP4 | -0.26 | -0.22 |
| LIMCH1 | -0.25 | -0.37 |
| SPIRE1 | -0.25 | -0.27 |
| EFNB2 | -0.25 | -0.22 |
| GPR22 | -0.25 | -0.14 |
| DACT1 | -0.25 | -0.12 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| PUJANA BRCA1 PCC NETWORK | 1652 | 1023 | All SZGR 2.0 genes in this pathway |
| PASQUALUCCI LYMPHOMA BY GC STAGE UP | 283 | 177 | All SZGR 2.0 genes in this pathway |
| BROWN MYELOID CELL DEVELOPMENT DN | 129 | 86 | All SZGR 2.0 genes in this pathway |
| LEE CALORIE RESTRICTION NEOCORTEX UP | 83 | 66 | All SZGR 2.0 genes in this pathway |
| XU GH1 EXOGENOUS TARGETS DN | 120 | 69 | All SZGR 2.0 genes in this pathway |
| MARSON BOUND BY FOXP3 STIMULATED | 1022 | 619 | All SZGR 2.0 genes in this pathway |
| CUI GLUCOSE DEPRIVATION | 60 | 44 | All SZGR 2.0 genes in this pathway |
| ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY | 1839 | 928 | All SZGR 2.0 genes in this pathway |