Summary ?
GeneID54797
SymbolMED18
Synonymsp28b
Descriptionmediator complex subunit 18
ReferenceMIM:612384|HGNC:HGNC:25944|Ensembl:ENSG00000130772|HPRD:17476|Vega:OTTHUMG00000003537
Gene typeprotein-coding
Map location1p35.3
Pascal p-value0.023
Fetal beta-0.055
DMG1 (# studies)

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg04889884128655616MED183.63E-8-0.0111.05E-5DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
MED10L6 | MGC5309 | NUT2 | TRG20mediator complex subunit 10Affinity Capture-MS
Affinity Capture-Western
BioGRID12584197 |14576168 
|14638676 |15175163 
MED19DT2P1G7 | LCMR1mediator complex subunit 19Affinity Capture-MS
Affinity Capture-Western
BioGRID14576168 |14638676 
|15175163 
MED20DKFZp586D2223 | MGC29869 | PRO0213 | TRFPmediator complex subunit 20-HPRD,BioGRID12584197 
MED20DKFZp586D2223 | MGC29869 | PRO0213 | TRFPmediator complex subunit 20TRFP interacts with p28b. This interaction was modelled on a demonstrated interaction between mouse TRFP and human p28b.BIND12584197 
MED25ACID1 | ARC92 | DKFZp434K0512 | MGC70671 | P78 | PTOV2 | TCBAP0758mediator complex subunit 25Affinity Capture-WesternBioGRID14638676 
MED26CRSP7 | CRSP70mediator complex subunit 26Affinity Capture-MSBioGRID15175163 
MED281500003D12Rik | DKFZp434N185 | EG1 | magicinmediator complex subunit 28Affinity Capture-MSBioGRID15175163 
MED29DKFZp434H247 | IXLmediator complex subunit 29-HPRD,BioGRID14576168 
MED9FLJ10193 | MED25 | MGC138234mediator complex subunit 9-HPRD14638676 
MED9FLJ10193 | MED25 | MGC138234mediator complex subunit 9Affinity Capture-MSBioGRID15175163 
THOC7FLJ23445 | NIF3L1BP1 | fSAP24THO complex 7 homolog (Drosophila)Reconstituted ComplexBioGRID12584197 
USP47DKFZp686C13257 | FLJ20727 | TRFPubiquitin specific peptidase 47-HPRD12584197 |14576168 
USP49MGC20741ubiquitin specific peptidase 49-HPRD12584197 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
REACTOME DEVELOPMENTAL BIOLOGY 396292All SZGR 2.0 genes in this pathway
REACTOME PPARA ACTIVATES GENE EXPRESSION 10472All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS 478302All SZGR 2.0 genes in this pathway
REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM 168115All SZGR 2.0 genes in this pathway
REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 7253All SZGR 2.0 genes in this pathway
PARENT MTOR SIGNALING UP 567375All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 10D UP 194122All SZGR 2.0 genes in this pathway
LASTOWSKA NEUROBLASTOMA COPY NUMBER DN 800473All SZGR 2.0 genes in this pathway
MARSON BOUND BY E2F4 UNSTIMULATED 728415All SZGR 2.0 genes in this pathway
KATSANOU ELAVL1 TARGETS DN 14888All SZGR 2.0 genes in this pathway