Gene Page: ALKBH5
Summary ?
| GeneID | 54890 |
| Symbol | ALKBH5 |
| Synonyms | ABH5|OFOXD|OFOXD1 |
| Description | alkB homolog 5, RNA demethylase |
| Reference | MIM:613303|HGNC:HGNC:25996|Ensembl:ENSG00000091542|HPRD:08621|Vega:OTTHUMG00000059397 |
| Gene type | protein-coding |
| Map location | 17p11.2|17p11.2 |
| Pascal p-value | 0.005 |
| Sherlock p-value | 0.839 |
| eGene | Cortex Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs6813178 | chr4 | 71575238 | ALKBH5 | 54890 | 0.09 | trans | ||
| rs2162141 | chr8 | 133799456 | ALKBH5 | 54890 | 0.12 | trans | ||
| rs235427 | chr8 | 133815575 | ALKBH5 | 54890 | 0.06 | trans | ||
| rs235428 | chr8 | 133815725 | ALKBH5 | 54890 | 0.12 | trans | ||
| rs235436 | chr8 | 133830342 | ALKBH5 | 54890 | 0.12 | trans | ||
| rs16904746 | chr8 | 133844507 | ALKBH5 | 54890 | 0.15 | trans | ||
| rs7000440 | chr8 | 133854402 | ALKBH5 | 54890 | 0.12 | trans | ||
| rs6471100 | 0 | ALKBH5 | 54890 | 0.09 | trans | |||
| rs864898 | chr8 | 133904379 | ALKBH5 | 54890 | 0.17 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| MRPS2 | 0.92 | 0.92 |
| TOR2A | 0.91 | 0.91 |
| DMAP1 | 0.91 | 0.89 |
| MED16 | 0.91 | 0.91 |
| TELO2 | 0.91 | 0.92 |
| ZNF408 | 0.90 | 0.89 |
| PTOV1 | 0.90 | 0.89 |
| ZNF668 | 0.90 | 0.92 |
| LRWD1 | 0.90 | 0.93 |
| ZNF653 | 0.90 | 0.92 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.31 | -0.75 | -0.79 |
| MT-CO2 | -0.75 | -0.79 |
| AF347015.33 | -0.74 | -0.79 |
| AF347015.27 | -0.74 | -0.80 |
| AF347015.8 | -0.73 | -0.80 |
| MT-CYB | -0.73 | -0.79 |
| AF347015.2 | -0.71 | -0.80 |
| AF347015.15 | -0.70 | -0.77 |
| AF347015.26 | -0.70 | -0.78 |
| AF347015.21 | -0.68 | -0.79 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL DN | 460 | 312 | All SZGR 2.0 genes in this pathway |
| KINSEY TARGETS OF EWSR1 FLII FUSION UP | 1278 | 748 | All SZGR 2.0 genes in this pathway |
| MOHANKUMAR TLX1 TARGETS UP | 414 | 287 | All SZGR 2.0 genes in this pathway |
| NUYTTEN EZH2 TARGETS DN | 1024 | 594 | All SZGR 2.0 genes in this pathway |
| JIANG HYPOXIA NORMAL | 311 | 205 | All SZGR 2.0 genes in this pathway |
| KRIEG HYPOXIA NOT VIA KDM3A | 770 | 480 | All SZGR 2.0 genes in this pathway |