Summary ?
GeneID54932
SymbolEXD3
Synonymsmut-7
Descriptionexonuclease 3'-5' domain containing 3
ReferenceHGNC:HGNC:26023|Ensembl:ENSG00000187609|HPRD:07906|Vega:OTTHUMG00000156149
Gene typeprotein-coding
Map location9q34.3
Pascal p-value0.3
Sherlock p-value9.269E-4
DMG1 (# studies)
eGeneMyers' cis & trans
SupportCompositeSet

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 2
DNM:Fromer_2014Whole Exome Sequencing analysisThis study reported a WES study of 623 schizophrenia trios, reporting DNMs using genomic DNA.

Section I. Genetics and epigenetics annotation

@DNM table

GeneChromosomePositionRefAltTranscriptAA changeMutation typeSiftCG46TraitStudy
EXD3chr9140267493CTNM_017820p.109R>QmissenseSchizophreniaDNM:Fromer_2014

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg212424179140263615EXD33.265E-40.2810.04DMG:Wockner_2014
cg117904389140317161NOXA1;EXD35.571E-4-0.2240.049DMG:Wockner_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs16853302chr1178686330EXD3549320.2trans
rs4449188chr2100549336EXD3549320.07trans
rs10274590chr749365101EXD3549320.19trans
rs2171076chr768550015EXD3549320trans
rs6530873chr815342889EXD3549320.05trans
rs11002835chr1080880899EXD3549320.17trans
rs10837895chr1142692512EXD3549320.17trans
rs3743707chr1659785925EXD3549320.12trans
rs3743706chr1659786019EXD3549320.12trans
rs7240399chr1855673549EXD3549320.13trans
rs8083456chr1855675432EXD3549320.13trans
rs17276168chr1868845841EXD3549327.789E-4trans
rs7238314chr1868929158EXD3549320.02trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
WANG CLIM2 TARGETS UP 269146All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP 1821933All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP 871505All SZGR 2.0 genes in this pathway
PEDRIOLI MIR31 TARGETS DN 418245All SZGR 2.0 genes in this pathway
ZWANG EGF INTERVAL UP 10546All SZGR 2.0 genes in this pathway