Gene Page: OXSM
Summary ?
| GeneID | 54995 |
| Symbol | OXSM |
| Synonyms | FASN2D|KASI|KS |
| Description | 3-oxoacyl-ACP synthase, mitochondrial |
| Reference | MIM:610324|HGNC:HGNC:26063|Ensembl:ENSG00000151093|HPRD:07931|Vega:OTTHUMG00000130477 |
| Gene type | protein-coding |
| Map location | 3p24.2 |
| Pascal p-value | 0.036 |
| Sherlock p-value | 0.78 |
| eGene | Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| GSMA_I | Genome scan meta-analysis | Psr: 0.006 |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| TFEB | 0.83 | 0.87 |
| PTGDS | 0.83 | 0.83 |
| MVP | 0.82 | 0.85 |
| PAQR6 | 0.81 | 0.84 |
| ZBTB7B | 0.81 | 0.85 |
| TMC6 | 0.80 | 0.84 |
| CYP27A1 | 0.79 | 0.84 |
| HAPLN2 | 0.79 | 0.79 |
| SEPT4 | 0.78 | 0.79 |
| PLA2G16 | 0.78 | 0.84 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| STMN1 | -0.62 | -0.71 |
| PPP3CC | -0.62 | -0.70 |
| ARMCX5 | -0.62 | -0.68 |
| GSTA4 | -0.62 | -0.69 |
| AC024270.1 | -0.61 | -0.69 |
| PARP6 | -0.61 | -0.66 |
| ZWILCH | -0.61 | -0.66 |
| ARMCX1 | -0.61 | -0.71 |
| ACVR2A | -0.61 | -0.69 |
| SUPV3L1 | -0.61 | -0.67 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0003735 | structural constituent of ribosome | IEA | - | |
| GO:0005524 | ATP binding | IEA | - | |
| GO:0004315 | 3-oxoacyl-[acyl-carrier-protein] synthase activity | IDA | 15668256 | |
| GO:0004672 | protein kinase activity | IEA | - | |
| GO:0016740 | transferase activity | IEA | - | |
| GO:0008415 | acyltransferase activity | IEA | - | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0006468 | protein amino acid phosphorylation | IEA | - | |
| GO:0006412 | translation | IEA | - | |
| GO:0006637 | acyl-CoA metabolic process | IDA | 15668256 | |
| GO:0051790 | short-chain fatty acid biosynthetic process | IDA | 15668256 | |
| GO:0051792 | medium-chain fatty acid biosynthetic process | IDA | 15668256 | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005840 | ribosome | IEA | - | |
| GO:0005622 | intracellular | IEA | - | |
| GO:0005739 | mitochondrion | IMP | 15668256 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| GRAESSMANN APOPTOSIS BY DOXORUBICIN DN | 1781 | 1082 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN | 770 | 415 | All SZGR 2.0 genes in this pathway |
| NUYTTEN NIPP1 TARGETS UP | 769 | 437 | All SZGR 2.0 genes in this pathway |
| WAKABAYASHI ADIPOGENESIS PPARG BOUND 36HR | 29 | 23 | All SZGR 2.0 genes in this pathway |
| WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D | 658 | 397 | All SZGR 2.0 genes in this pathway |