Summary ?
GeneID550
SymbolAUP1
Synonyms-
Descriptionancient ubiquitous protein 1
ReferenceMIM:602434|HGNC:HGNC:891|Ensembl:ENSG00000115307|HPRD:03892|Vega:OTTHUMG00000129964
Gene typeprotein-coding
Map location2p13
Pascal p-value0.205
Sherlock p-value0.521
Fetal beta0.384
DMG1 (# studies)
eGeneHypothalamus

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
DMG:Montano_2016Genome-wide DNA methylation analysisThis dataset includes 172 replicated associations between CpGs with schizophrenia. 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg06721411274753759AUP12.67E-60.0090.023DMG:Montano_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
HOMER20.650.47
PITPNM10.620.49
GALNT140.600.41
ZDHHC220.590.41
PAPPA0.590.20
PTPN30.590.31
NOD20.580.10
CHRNA40.580.51
TPH20.570.14
NTNG10.570.32
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
OAF-0.26-0.36
GRIN2C-0.26-0.34
AIF1L-0.26-0.37
HEPN1-0.25-0.36
AF347015.2-0.25-0.36
NDUFA4L2-0.25-0.33
S100A1-0.25-0.35
SELENBP1-0.25-0.34
WIF1-0.24-0.32
FXYD1-0.24-0.35

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ATG12APG12 | APG12L | FBR93 | HAPG12ATG12 autophagy related 12 homolog (S. cerevisiae)Affinity Capture-MSBioGRID17353931 
ILKDKFZp686F1765 | P59integrin-linked kinaseAffinity Capture-MSBioGRID17353931 
ITGA1CD49a | VLA1integrin, alpha 1-HPRD,BioGRID12042322 
ITGA2BR | CD49B | GPIa | VLA-2 | VLAA2integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)-HPRD,BioGRID12042322 
ITGA2BCD41 | CD41B | GP2B | GPIIb | GTA | HPA3integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)-HPRD,BioGRID12042322 
ITGA5CD49e | FNRA | VLA5Aintegrin, alpha 5 (fibronectin receptor, alpha polypeptide)-HPRD,BioGRID12042322 
ITGAMCD11B | CR3A | MAC-1 | MAC1A | MGC117044 | MO1A | SLEB6integrin, alpha M (complement component 3 receptor 3 subunit)-HPRD,BioGRID12042322 
ITGAVCD51 | DKFZp686A08142 | MSK8 | VNRAintegrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)-HPRD,BioGRID12042322 
KPTN2E4kaptin (actin binding protein)Affinity Capture-MSBioGRID17353931 
NDNHsT16328 | PWCRnecdin homolog (mouse)Affinity Capture-MSBioGRID17353931 
UBE2G2UBC7ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog, yeast)Affinity Capture-MSBioGRID17353931 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
ONKEN UVEAL MELANOMA UP 783507All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382904All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN UP 479299All SZGR 2.0 genes in this pathway
JIANG HYPOXIA CANCER 8352All SZGR 2.0 genes in this pathway
HAN SATB1 TARGETS DN 442275All SZGR 2.0 genes in this pathway
COLINA TARGETS OF 4EBP1 AND 4EBP2 356214All SZGR 2.0 genes in this pathway