Gene Page: LAMTOR1
Summary ?
| GeneID | 55004 |
| Symbol | LAMTOR1 |
| Synonyms | C11orf59|PDRO|Ragulator1|p18|p27RF-Rho |
| Description | late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 |
| Reference | MIM:613510|HGNC:HGNC:26068|Ensembl:ENSG00000149357|HPRD:07933|Vega:OTTHUMG00000167869 |
| Gene type | protein-coding |
| Map location | 11q13.4 |
| Pascal p-value | 0.04 |
| Sherlock p-value | 0.129 |
| eGene | Myers' cis & trans Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs9364293 | chr6 | 169199078 | LAMTOR1 | 55004 | 0.08 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| EDF1 | 0.85 | 0.87 |
| INO80E | 0.84 | 0.88 |
| MRPS26 | 0.84 | 0.86 |
| DRAP1 | 0.84 | 0.86 |
| INO80B | 0.83 | 0.84 |
| CCDC12 | 0.83 | 0.87 |
| C19orf43 | 0.82 | 0.88 |
| WDR74 | 0.82 | 0.83 |
| PFDN2 | 0.81 | 0.82 |
| C11orf48 | 0.81 | 0.80 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.33 | -0.62 | -0.71 |
| MT-CO2 | -0.62 | -0.69 |
| AF347015.31 | -0.62 | -0.71 |
| MT-CYB | -0.61 | -0.72 |
| AF347015.2 | -0.60 | -0.71 |
| AF347015.9 | -0.60 | -0.74 |
| AF347015.8 | -0.59 | -0.70 |
| AF347015.15 | -0.59 | -0.72 |
| AF347015.26 | -0.58 | -0.70 |
| AF347015.27 | -0.58 | -0.69 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| LASTOWSKA NEUROBLASTOMA COPY NUMBER DN | 800 | 473 | All SZGR 2.0 genes in this pathway |
| LOCKWOOD AMPLIFIED IN LUNG CANCER | 214 | 139 | All SZGR 2.0 genes in this pathway |
| STARK PREFRONTAL CORTEX 22Q11 DELETION DN | 517 | 309 | All SZGR 2.0 genes in this pathway |
| DOUGLAS BMI1 TARGETS UP | 566 | 371 | All SZGR 2.0 genes in this pathway |
| MARSON BOUND BY FOXP3 UNSTIMULATED | 1229 | 713 | All SZGR 2.0 genes in this pathway |
| ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP | 863 | 514 | All SZGR 2.0 genes in this pathway |
| YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 17 | 181 | 101 | All SZGR 2.0 genes in this pathway |
| PILON KLF1 TARGETS DN | 1972 | 1213 | All SZGR 2.0 genes in this pathway |
| WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D | 658 | 397 | All SZGR 2.0 genes in this pathway |
| RATTENBACHER BOUND BY CELF1 | 467 | 251 | All SZGR 2.0 genes in this pathway |