Summary ?
GeneID55027
SymbolHEATR3
SynonymsSYO1
DescriptionHEAT repeat containing 3
ReferenceMIM:614951|HGNC:HGNC:26087|HPRD:07945|
Gene typeprotein-coding
Map location16q12.1
Pascal p-value0.117
Sherlock p-value0.582
Fetal beta0.803
eGeneAnterior cingulate cortex BA24
Caudate basal ganglia
Cerebellar Hemisphere
Cerebellum
Cortex
Frontal Cortex BA9
Hippocampus
Hypothalamus
Nucleus accumbens basal ganglia
Putamen basal ganglia
Myers' cis & trans
Meta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
CV:PGCnpGenome-wide Association StudyGWAS
GSMA_IIEGenome scan meta-analysis (European-ancestry samples)Psr: 0.01775 

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs871482chr1487071062HEATR3550270.18trans
rs11874111650034680HEATR3ENSG00000155393.83.288E-70-65172gtex_brain_ba24
rs47853751650041983HEATR3ENSG00000155393.82.345E-70-57869gtex_brain_ba24
rs121489441650042362HEATR3ENSG00000155393.82.34E-70-57490gtex_brain_ba24
rs96734941650043558HEATR3ENSG00000155393.82.331E-70-56294gtex_brain_ba24
rs110765101650047296HEATR3ENSG00000155393.82.311E-70-52556gtex_brain_ba24
rs129232191650052216HEATR3ENSG00000155393.82.223E-70-47636gtex_brain_ba24
rs116431641650056554HEATR3ENSG00000155393.82.196E-70-43298gtex_brain_ba24
rs116429091650056698HEATR3ENSG00000155393.81.207E-60-43154gtex_brain_ba24
rs20588151650058219HEATR3ENSG00000155393.83.036E-80-41633gtex_brain_ba24
rs13626331650062572HEATR3ENSG00000155393.81.575E-80-37280gtex_brain_ba24
rs20419201650068422HEATR3ENSG00000155393.81.575E-80-31430gtex_brain_ba24
rs21605681650068445HEATR3ENSG00000155393.81.575E-80-31407gtex_brain_ba24
rs20419181650069312HEATR3ENSG00000155393.81.575E-80-30540gtex_brain_ba24
rs14206891650075276HEATR3ENSG00000155393.82.186E-80-24576gtex_brain_ba24
rs46194031650075548HEATR3ENSG00000155393.81.571E-80-24304gtex_brain_ba24
rs80491541650075993HEATR3ENSG00000155393.83.246E-70-23859gtex_brain_ba24
rs350983611650079250HEATR3ENSG00000155393.88.858E-70-20602gtex_brain_ba24
rs561980681650079253HEATR3ENSG00000155393.88.635E-70-20599gtex_brain_ba24
rs129225411650079390HEATR3ENSG00000155393.81.544E-80-20462gtex_brain_ba24
rs129184571650088068HEATR3ENSG00000155393.83.552E-90-11784gtex_brain_ba24
rs677733241650088999HEATR3ENSG00000155393.84.032E-90-10853gtex_brain_ba24
rs1998064501650089003HEATR3ENSG00000155393.81.408E-80-10849gtex_brain_ba24
rs721163181650089132HEATR3ENSG00000155393.81.716E-90-10720gtex_brain_ba24
rs71868891650092291HEATR3ENSG00000155393.89.178E-100-7561gtex_brain_ba24
rs125992601650093238HEATR3ENSG00000155393.87.144E-100-6614gtex_brain_ba24
rs18616611650094204HEATR3ENSG00000155393.87.144E-100-5648gtex_brain_ba24
rs129333251650097444HEATR3ENSG00000155393.87.144E-100-2408gtex_brain_ba24
rs80468561650098887HEATR3ENSG00000155393.87.144E-100-965gtex_brain_ba24
rs80524921650099747HEATR3ENSG00000155393.87.144E-100-105gtex_brain_ba24
rs80519021650099777HEATR3ENSG00000155393.87.144E-100-75gtex_brain_ba24
rs43891391650100253HEATR3ENSG00000155393.87.144E-100401gtex_brain_ba24
rs15474781650101015HEATR3ENSG00000155393.87.144E-1001163gtex_brain_ba24
rs561137511650101434HEATR3ENSG00000155393.81.062E-901582gtex_brain_ba24
rs556468141650101526HEATR3ENSG00000155393.81.17E-901674gtex_brain_ba24
rs10088151650102220HEATR3ENSG00000155393.82.133E-602368gtex_brain_ba24
rs22871971650106594HEATR3ENSG00000155393.87.144E-1006742gtex_brain_ba24
rs80475041650107635HEATR3ENSG00000155393.81.062E-907783gtex_brain_ba24
rs590594231650108102HEATR3ENSG00000155393.81.062E-908250gtex_brain_ba24
rs129320381650108615HEATR3ENSG00000155393.81.062E-908763gtex_brain_ba24
rs99396881650109100HEATR3ENSG00000155393.81.062E-909248gtex_brain_ba24
rs129314971650109478HEATR3ENSG00000155393.81.062E-909626gtex_brain_ba24
rs561894551650110650HEATR3ENSG00000155393.82.031E-9010798gtex_brain_ba24
rs64167851650111074HEATR3ENSG00000155393.81.27E-9011222gtex_brain_ba24
rs72033481650112267HEATR3ENSG00000155393.81.062E-9012415gtex_brain_ba24
rs80512161650113773HEATR3ENSG00000155393.81.062E-9013921gtex_brain_ba24
rs21605701650114505HEATR3ENSG00000155393.81.082E-9014653gtex_brain_ba24
rs21605711650114555HEATR3ENSG00000155393.87.144E-10014703gtex_brain_ba24
rs800247681650116681HEATR3ENSG00000155393.83.864E-9016829gtex_brain_ba24
rs2007834891650116682HEATR3ENSG00000155393.83.501E-9016830gtex_brain_ba24
rs711380301650116683HEATR3ENSG00000155393.82.359E-9016831gtex_brain_ba24
rs45911441650116803HEATR3ENSG00000155393.83.008E-9016951gtex_brain_ba24
rs44428041650116819HEATR3ENSG00000155393.82.297E-8016967gtex_brain_ba24
rs46353431650116999HEATR3ENSG00000155393.81.083E-9017147gtex_brain_ba24
rs80477421650117316HEATR3ENSG00000155393.81.062E-9017464gtex_brain_ba24
rs8776391650118245HEATR3ENSG00000155393.81.062E-9018393gtex_brain_ba24
rs20805041650119170HEATR3ENSG00000155393.81.062E-9019318gtex_brain_ba24
rs22871961650120122HEATR3ENSG00000155393.81.062E-9020270gtex_brain_ba24
rs20054021650120668HEATR3ENSG00000155393.81.062E-9020816gtex_brain_ba24
rs2018445261650120866HEATR3ENSG00000155393.85.771E-9021014gtex_brain_ba24
rs23568351650120867HEATR3ENSG00000155393.81.078E-9021015gtex_brain_ba24
rs23568361650120869HEATR3ENSG00000155393.81.078E-9021017gtex_brain_ba24
rs23568371650120893HEATR3ENSG00000155393.82.513E-6021041gtex_brain_ba24
rs23568381650120983HEATR3ENSG00000155393.81.062E-9021131gtex_brain_ba24
rs80463441650121773HEATR3ENSG00000155393.81.062E-9021921gtex_brain_ba24
rs80575241650122946HEATR3ENSG00000155393.81.062E-9023094gtex_brain_ba24
rs2010198821650123309HEATR3ENSG00000155393.81.072E-9023457gtex_brain_ba24
rs74982421650125145HEATR3ENSG00000155393.87.144E-10025293gtex_brain_ba24
rs71908901650125856HEATR3ENSG00000155393.81.062E-9026004gtex_brain_ba24
rs575678221650126657HEATR3ENSG00000155393.81.062E-9026805gtex_brain_ba24
rs129300791650126691HEATR3ENSG00000155393.87.144E-10026839gtex_brain_ba24
rs116426951650127120HEATR3ENSG00000155393.87.097E-10027268gtex_brain_ba24
rs108526061650128872HEATR3ENSG00000155393.81.018E-9029020gtex_brain_ba24
rs80474211650129265HEATR3ENSG00000155393.88.759E-7029413gtex_brain_ba24
rs20588131650129454HEATR3ENSG00000155393.82.513E-6029602gtex_brain_ba24
rs129263461650130045HEATR3ENSG00000155393.83.031E-8030193gtex_brain_ba24
rs584412521650130265HEATR3ENSG00000155393.82.305E-6030413gtex_brain_ba24
rs80621511650130512HEATR3ENSG00000155393.82.516E-6030660gtex_brain_ba24
rs116425791650132080HEATR3ENSG00000155393.82.526E-6032228gtex_brain_ba24
rs47853811650133789HEATR3ENSG00000155393.82.541E-6033937gtex_brain_ba24
rs113552271650134008HEATR3ENSG00000155393.82.544E-6034156gtex_brain_ba24
rs116406271650137901HEATR3ENSG00000155393.82.556E-6038049gtex_brain_ba24
rs65002821650138100HEATR3ENSG00000155393.87.336E-10038248gtex_brain_ba24
rs80523501650139285HEATR3ENSG00000155393.82.584E-6039433gtex_brain_ba24
rs15588131650139799HEATR3ENSG00000155393.82.581E-6039947gtex_brain_ba24
rs40746551650146244HEATR3ENSG00000155393.85.669E-7046392gtex_brain_ba24
rs40746541650146446HEATR3ENSG00000155393.82.036E-7046594gtex_brain_ba24
rs38922701650146549HEATR3ENSG00000155393.81.692E-6046697gtex_brain_ba24
rs65002851650146653HEATR3ENSG00000155393.82.039E-7046801gtex_brain_ba24
rs47853831650147802HEATR3ENSG00000155393.85.431E-7047950gtex_brain_ba24
rs47853841650147993HEATR3ENSG00000155393.85.445E-7048141gtex_brain_ba24
rs65002871650148333HEATR3ENSG00000155393.85.465E-7048481gtex_brain_ba24
rs65002881650148408HEATR3ENSG00000155393.85.468E-7048556gtex_brain_ba24
rs72067351650148508HEATR3ENSG00000155393.85.478E-7048656gtex_brain_ba24
rs13626341650148774HEATR3ENSG00000155393.85.502E-7048922gtex_brain_ba24
rs118650011650150547HEATR3ENSG00000155393.82.061E-7050695gtex_brain_ba24
rs43965351650151287HEATR3ENSG00000155393.81.44E-7051435gtex_brain_ba24
rs71913591650151301HEATR3ENSG00000155393.82.093E-7051449gtex_brain_ba24
rs65002901650151319HEATR3ENSG00000155393.85.762E-7051467gtex_brain_ba24
rs71849401650151461HEATR3ENSG00000155393.85.517E-7051609gtex_brain_ba24
rs65002911650154813HEATR3ENSG00000155393.82.73E-6054961gtex_brain_ba24
rs129204421650157437HEATR3ENSG00000155393.85.657E-7057585gtex_brain_ba24
rs11874111650034680HEATR3ENSG00000155393.89.606E-100-65172gtex_brain_putamen_basal
rs47853751650041983HEATR3ENSG00000155393.81.117E-90-57869gtex_brain_putamen_basal
rs121489441650042362HEATR3ENSG00000155393.81.123E-90-57490gtex_brain_putamen_basal
rs96734941650043558HEATR3ENSG00000155393.81.14E-90-56294gtex_brain_putamen_basal
rs110765101650047296HEATR3ENSG00000155393.83.616E-100-52556gtex_brain_putamen_basal
rs129232191650052216HEATR3ENSG00000155393.86.137E-110-47636gtex_brain_putamen_basal
rs116431641650056554HEATR3ENSG00000155393.86.507E-110-43298gtex_brain_putamen_basal
rs116429091650056698HEATR3ENSG00000155393.81.618E-100-43154gtex_brain_putamen_basal
rs20588151650058219HEATR3ENSG00000155393.83.154E-110-41633gtex_brain_putamen_basal
rs13626331650062572HEATR3ENSG00000155393.84.214E-100-37280gtex_brain_putamen_basal
rs20419201650068422HEATR3ENSG00000155393.84.268E-100-31430gtex_brain_putamen_basal
rs21605681650068445HEATR3ENSG00000155393.84.268E-100-31407gtex_brain_putamen_basal
rs20419181650069312HEATR3ENSG00000155393.84.277E-100-30540gtex_brain_putamen_basal
rs14206891650075276HEATR3ENSG00000155393.84.313E-100-24576gtex_brain_putamen_basal
rs46194031650075548HEATR3ENSG00000155393.84.313E-100-24304gtex_brain_putamen_basal
rs80491541650075993HEATR3ENSG00000155393.81.135E-90-23859gtex_brain_putamen_basal
rs350983611650079250HEATR3ENSG00000155393.83.724E-90-20602gtex_brain_putamen_basal
rs561980681650079253HEATR3ENSG00000155393.83.403E-90-20599gtex_brain_putamen_basal
rs129225411650079390HEATR3ENSG00000155393.81.293E-100-20462gtex_brain_putamen_basal
rs129183591650087641HEATR3ENSG00000155393.83.834E-60-12211gtex_brain_putamen_basal
rs129184571650088068HEATR3ENSG00000155393.81.408E-100-11784gtex_brain_putamen_basal
rs677733241650088999HEATR3ENSG00000155393.82.281E-110-10853gtex_brain_putamen_basal
rs1998064501650089003HEATR3ENSG00000155393.81.549E-110-10849gtex_brain_putamen_basal
rs124473241650089038HEATR3ENSG00000155393.87.565E-80-10814gtex_brain_putamen_basal
rs721163181650089132HEATR3ENSG00000155393.83.256E-110-10720gtex_brain_putamen_basal
rs71868891650092291HEATR3ENSG00000155393.82.682E-100-7561gtex_brain_putamen_basal
rs125992601650093238HEATR3ENSG00000155393.83.233E-100-6614gtex_brain_putamen_basal
rs18616611650094204HEATR3ENSG00000155393.83.233E-100-5648gtex_brain_putamen_basal
rs129333251650097444HEATR3ENSG00000155393.83.234E-100-2408gtex_brain_putamen_basal
rs80468561650098887HEATR3ENSG00000155393.83.253E-100-965gtex_brain_putamen_basal
rs80524921650099747HEATR3ENSG00000155393.83.233E-100-105gtex_brain_putamen_basal
rs80519021650099777HEATR3ENSG00000155393.83.233E-100-75gtex_brain_putamen_basal
rs43891391650100253HEATR3ENSG00000155393.83.233E-100401gtex_brain_putamen_basal
rs15474781650101015HEATR3ENSG00000155393.83.233E-1001163gtex_brain_putamen_basal
rs561137511650101434HEATR3ENSG00000155393.84.122E-1001582gtex_brain_putamen_basal
rs556468141650101526HEATR3ENSG00000155393.84.087E-1001674gtex_brain_putamen_basal
rs10088151650102220HEATR3ENSG00000155393.85.089E-702368gtex_brain_putamen_basal
rs22871971650106594HEATR3ENSG00000155393.83.233E-1006742gtex_brain_putamen_basal
rs80475041650107635HEATR3ENSG00000155393.84.122E-1007783gtex_brain_putamen_basal
rs590594231650108102HEATR3ENSG00000155393.84.122E-1008250gtex_brain_putamen_basal
rs129320381650108615HEATR3ENSG00000155393.84.122E-1008763gtex_brain_putamen_basal
rs99396881650109100HEATR3ENSG00000155393.84.122E-1009248gtex_brain_putamen_basal
rs129314971650109478HEATR3ENSG00000155393.84.122E-1009626gtex_brain_putamen_basal
rs561894551650110650HEATR3ENSG00000155393.86.581E-10010798gtex_brain_putamen_basal
rs64167851650111074HEATR3ENSG00000155393.82.284E-8011222gtex_brain_putamen_basal
rs72033481650112267HEATR3ENSG00000155393.81.105E-9012415gtex_brain_putamen_basal
rs80512161650113773HEATR3ENSG00000155393.81.105E-9013921gtex_brain_putamen_basal
rs21605701650114505HEATR3ENSG00000155393.85.024E-10014653gtex_brain_putamen_basal
rs21605711650114555HEATR3ENSG00000155393.83.233E-10014703gtex_brain_putamen_basal
rs800247681650116681HEATR3ENSG00000155393.81.081E-9016829gtex_brain_putamen_basal
rs2007834891650116682HEATR3ENSG00000155393.83.015E-10016830gtex_brain_putamen_basal
rs711380301650116683HEATR3ENSG00000155393.83.191E-10016831gtex_brain_putamen_basal
rs45911441650116803HEATR3ENSG00000155393.88.476E-10016951gtex_brain_putamen_basal
rs44428041650116819HEATR3ENSG00000155393.81.734E-10016967gtex_brain_putamen_basal
rs46353431650116999HEATR3ENSG00000155393.81.22E-9017147gtex_brain_putamen_basal
rs80477421650117316HEATR3ENSG00000155393.81.105E-9017464gtex_brain_putamen_basal
rs8776391650118245HEATR3ENSG00000155393.81.105E-9018393gtex_brain_putamen_basal
rs20805041650119170HEATR3ENSG00000155393.81.105E-9019318gtex_brain_putamen_basal
rs22871961650120122HEATR3ENSG00000155393.81.105E-9020270gtex_brain_putamen_basal
rs20054021650120668HEATR3ENSG00000155393.81.105E-9020816gtex_brain_putamen_basal
rs2018445261650120866HEATR3ENSG00000155393.81.415E-9021014gtex_brain_putamen_basal
rs23568351650120867HEATR3ENSG00000155393.81.059E-9021015gtex_brain_putamen_basal
rs23568361650120869HEATR3ENSG00000155393.81.059E-9021017gtex_brain_putamen_basal
rs23568371650120893HEATR3ENSG00000155393.81.327E-6021041gtex_brain_putamen_basal
rs23568381650120983HEATR3ENSG00000155393.81.105E-9021131gtex_brain_putamen_basal
rs80463441650121773HEATR3ENSG00000155393.81.101E-9021921gtex_brain_putamen_basal
rs80575241650122946HEATR3ENSG00000155393.81.105E-9023094gtex_brain_putamen_basal
rs2010198821650123309HEATR3ENSG00000155393.82.907E-9023457gtex_brain_putamen_basal
rs74982421650125145HEATR3ENSG00000155393.83.233E-10025293gtex_brain_putamen_basal
rs71908901650125856HEATR3ENSG00000155393.81.105E-9026004gtex_brain_putamen_basal
rs575678221650126657HEATR3ENSG00000155393.81.105E-9026805gtex_brain_putamen_basal
rs129300791650126691HEATR3ENSG00000155393.81.046E-9026839gtex_brain_putamen_basal
rs116426951650127120HEATR3ENSG00000155393.83.224E-10027268gtex_brain_putamen_basal
rs108526061650128872HEATR3ENSG00000155393.81.098E-9029020gtex_brain_putamen_basal
rs80474211650129265HEATR3ENSG00000155393.81.301E-6029413gtex_brain_putamen_basal
rs20588131650129454HEATR3ENSG00000155393.81.327E-6029602gtex_brain_putamen_basal
rs129263461650130045HEATR3ENSG00000155393.81.243E-9030193gtex_brain_putamen_basal
rs584412521650130265HEATR3ENSG00000155393.84.114E-7030413gtex_brain_putamen_basal
rs80621511650130512HEATR3ENSG00000155393.81.258E-6030660gtex_brain_putamen_basal
rs116425791650132080HEATR3ENSG00000155393.81.314E-6032228gtex_brain_putamen_basal
rs47853811650133789HEATR3ENSG00000155393.81.325E-6033937gtex_brain_putamen_basal
rs113552271650134008HEATR3ENSG00000155393.81.327E-6034156gtex_brain_putamen_basal
rs116406271650137901HEATR3ENSG00000155393.81.325E-6038049gtex_brain_putamen_basal
rs65002821650138100HEATR3ENSG00000155393.81.218E-9038248gtex_brain_putamen_basal
rs80523501650139285HEATR3ENSG00000155393.86.842E-7039433gtex_brain_putamen_basal
rs15588131650139799HEATR3ENSG00000155393.81.328E-6039947gtex_brain_putamen_basal
rs40746551650146244HEATR3ENSG00000155393.82.567E-6046392gtex_brain_putamen_basal
rs38922701650146549HEATR3ENSG00000155393.82.883E-6046697gtex_brain_putamen_basal
rs72005511650147639HEATR3ENSG00000155393.82.502E-6047787gtex_brain_putamen_basal
rs47853831650147802HEATR3ENSG00000155393.82.576E-6047950gtex_brain_putamen_basal
rs47853841650147993HEATR3ENSG00000155393.82.577E-6048141gtex_brain_putamen_basal
rs65002871650148333HEATR3ENSG00000155393.82.58E-6048481gtex_brain_putamen_basal
rs65002881650148408HEATR3ENSG00000155393.82.58E-6048556gtex_brain_putamen_basal
rs72067351650148508HEATR3ENSG00000155393.82.582E-6048656gtex_brain_putamen_basal
rs13626341650148774HEATR3ENSG00000155393.82.585E-6048922gtex_brain_putamen_basal
rs43965351650151287HEATR3ENSG00000155393.83.544E-6051435gtex_brain_putamen_basal
rs65002901650151319HEATR3ENSG00000155393.82.609E-6051467gtex_brain_putamen_basal
rs71849401650151461HEATR3ENSG00000155393.82.598E-6051609gtex_brain_putamen_basal
rs2018727621650152455HEATR3ENSG00000155393.87.799E-7052603gtex_brain_putamen_basal
rs97465491650152456HEATR3ENSG00000155393.82.048E-6052604gtex_brain_putamen_basal
rs129204421650157437HEATR3ENSG00000155393.82.587E-6057585gtex_brain_putamen_basal
rs47853861650164049HEATR3ENSG00000155393.81.114E-6064197gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005488bindingIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
GAZDA DIAMOND BLACKFAN ANEMIA ERYTHROID DN 493298All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LIVE DN 384220All SZGR 2.0 genes in this pathway
GINESTIER BREAST CANCER ZNF217 AMPLIFIED UP 7848All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 24HR UP 557331All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE FIMA DN 284156All SZGR 2.0 genes in this pathway
SHEPARD CRUSH AND BURN MUTANT UP 197110All SZGR 2.0 genes in this pathway
MANALO HYPOXIA DN 289166All SZGR 2.0 genes in this pathway
OKUMURA INFLAMMATORY RESPONSE LPS 183115All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 2 473224All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN 882538All SZGR 2.0 genes in this pathway
RATTENBACHER BOUND BY CELF1 467251All SZGR 2.0 genes in this pathway