Gene Page: PPP1R8
Summary ?
| GeneID | 5511 |
| Symbol | PPP1R8 |
| Synonyms | ARD-1|ARD1|NIPP-1|NIPP1|PRO2047 |
| Description | protein phosphatase 1 regulatory subunit 8 |
| Reference | MIM:602636|HGNC:HGNC:9296|Ensembl:ENSG00000117751|HPRD:04028|Vega:OTTHUMG00000003734 |
| Gene type | protein-coding |
| Map location | 1p35.3 |
| Pascal p-value | 0.307 |
| Sherlock p-value | 0.369 |
| Fetal beta | 0.504 |
| DMG | 1 (# studies) |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| ch.1.928723R | 1 | 28176880 | PPP1R8 | 1.532E-4 | -0.53 | 0.032 | DMG:Wockner_2014 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| C14orf1 | ERG28 | NET51 | chromosome 14 open reading frame 1 | Two-hybrid | BioGRID | 16169070 |
| C7orf64 | DKFZP564O0523 | DKFZp686D1651 | HSPC304 | chromosome 7 open reading frame 64 | Two-hybrid | BioGRID | 16169070 |
| CDC5L | CEF1 | KIAA0432 | PCDC5RP | dJ319D22.1 | hCDC5 | CDC5 cell division cycle 5-like (S. pombe) | - | HPRD,BioGRID | 10827081 |
| CRMP1 | DPYSL1 | DRP-1 | DRP1 | collapsin response mediator protein 1 | Two-hybrid | BioGRID | 16169070 |
| EED | HEED | WAIT1 | embryonic ectoderm development | - | HPRD,BioGRID | 12788942 |
| GBP2 | - | guanylate binding protein 2, interferon-inducible | Two-hybrid | BioGRID | 16169070 |
| HDAC2 | RPD3 | YAF1 | histone deacetylase 2 | - | HPRD,BioGRID | 12788942 |
| LYN | FLJ26625 | JTK8 | v-yes-1 Yamaguchi sarcoma viral related oncogene homolog | - | HPRD,BioGRID | 11104670 |
| NME2 | MGC111212 | NDPK-B | NDPKB | NM23-H2 | NM23B | puf | non-metastatic cells 2, protein (NM23B) expressed in | Affinity Capture-MS | BioGRID | 17353931 |
| PPP1CA | MGC15877 | MGC1674 | PP-1A | PPP1A | protein phosphatase 1, catalytic subunit, alpha isoform | Reconstituted Complex | BioGRID | 10637318 |12788942 |
| PPP1CB | MGC3672 | PP-1B | PPP1CD | protein phosphatase 1, catalytic subunit, beta isoform | Affinity Capture-MS | BioGRID | 17353931 |
| PPP1CC | PPP1G | protein phosphatase 1, catalytic subunit, gamma isoform | Reconstituted Complex | BioGRID | 11104670 |
| PRKACA | MGC102831 | MGC48865 | PKACA | protein kinase, cAMP-dependent, catalytic, alpha | Biochemical Activity | BioGRID | 9407077 |
| SETDB1 | ESET | KG1T | KIAA0067 | KMT1E | SET domain, bifurcated 1 | Two-hybrid | BioGRID | 16169070 |
| SF3B1 | PRP10 | PRPF10 | SAP155 | SF3b155 | splicing factor 3b, subunit 1, 155kDa | Affinity Capture-Western Reconstituted Complex Two-hybrid | BioGRID | 12105215 |
| STC2 | STC-2 | STCRP | stanniocalcin 2 | Two-hybrid | BioGRID | 16169070 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP | 1382 | 904 | All SZGR 2.0 genes in this pathway |
| MULLIGHAN NPM1 MUTATED SIGNATURE 1 UP | 276 | 165 | All SZGR 2.0 genes in this pathway |
| MULLIGHAN NPM1 SIGNATURE 3 UP | 341 | 197 | All SZGR 2.0 genes in this pathway |
| KINSEY TARGETS OF EWSR1 FLII FUSION UP | 1278 | 748 | All SZGR 2.0 genes in this pathway |
| MCBRYAN PUBERTAL BREAST 4 5WK DN | 196 | 131 | All SZGR 2.0 genes in this pathway |
| MCBRYAN PUBERTAL BREAST 5 6WK UP | 116 | 68 | All SZGR 2.0 genes in this pathway |
| LASTOWSKA NEUROBLASTOMA COPY NUMBER DN | 800 | 473 | All SZGR 2.0 genes in this pathway |
| SCHLOSSER SERUM RESPONSE DN | 712 | 443 | All SZGR 2.0 genes in this pathway |
| AMUNDSON GENOTOXIC SIGNATURE | 105 | 68 | All SZGR 2.0 genes in this pathway |
| GRUETZMANN PANCREATIC CANCER UP | 358 | 245 | All SZGR 2.0 genes in this pathway |
| SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN | 584 | 395 | All SZGR 2.0 genes in this pathway |
| PUJANA BRCA1 PCC NETWORK | 1652 | 1023 | All SZGR 2.0 genes in this pathway |
| PUJANA CHEK2 PCC NETWORK | 779 | 480 | All SZGR 2.0 genes in this pathway |
| NUYTTEN NIPP1 TARGETS DN | 848 | 527 | All SZGR 2.0 genes in this pathway |
| WEIGEL OXIDATIVE STRESS BY TBH AND H2O2 | 36 | 24 | All SZGR 2.0 genes in this pathway |
| GENTILE UV LOW DOSE UP | 27 | 19 | All SZGR 2.0 genes in this pathway |
| MARIADASON RESPONSE TO CURCUMIN SULINDAC 7 | 19 | 10 | All SZGR 2.0 genes in this pathway |
| ALONSO METASTASIS UP | 198 | 128 | All SZGR 2.0 genes in this pathway |
| HOFMANN MYELODYSPLASTIC SYNDROM RISK DN | 23 | 12 | All SZGR 2.0 genes in this pathway |
| COLINA TARGETS OF 4EBP1 AND 4EBP2 | 356 | 214 | All SZGR 2.0 genes in this pathway |
| PILON KLF1 TARGETS DN | 1972 | 1213 | All SZGR 2.0 genes in this pathway |
| JOHNSTONE PARVB TARGETS 3 DN | 918 | 550 | All SZGR 2.0 genes in this pathway |
| LEE BMP2 TARGETS DN | 882 | 538 | All SZGR 2.0 genes in this pathway |