Gene Page: PIWIL2
Summary ?
| GeneID | 55124 |
| Symbol | PIWIL2 |
| Synonyms | CT80|HILI|PIWIL1L|mili |
| Description | piwi-like RNA-mediated gene silencing 2 |
| Reference | MIM:610312|HGNC:HGNC:17644|Ensembl:ENSG00000197181|HPRD:11434|Vega:OTTHUMG00000097767 |
| Gene type | protein-coding |
| Map location | 8p21.3 |
| Pascal p-value | 0.016 |
| Fetal beta | 0.922 |
| eGene | Caudate basal ganglia Cerebellar Hemisphere Cerebellum Hypothalamus Nucleus accumbens basal ganglia Putamen basal ganglia Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| GSMA_I | Genome scan meta-analysis | Psr: 0.031 | |
| GSMA_IIE | Genome scan meta-analysis (European-ancestry samples) | Psr: 0.00057 | |
| GSMA_IIA | Genome scan meta-analysis (All samples) | Psr: 0.03086 | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs6982901 | 8 | 22103896 | PIWIL2 | ENSG00000197181.7 | 8.4E-8 | 0 | -28914 | gtex_brain_putamen_basal |
| rs4598250 | 8 | 22103952 | PIWIL2 | ENSG00000197181.7 | 6.005E-8 | 0 | -28858 | gtex_brain_putamen_basal |
| rs7001697 | 8 | 22107240 | PIWIL2 | ENSG00000197181.7 | 6.242E-7 | 0 | -25570 | gtex_brain_putamen_basal |
| rs2645 | 8 | 22108347 | PIWIL2 | ENSG00000197181.7 | 4.207E-7 | 0 | -24463 | gtex_brain_putamen_basal |
| rs4872462 | 8 | 22132033 | PIWIL2 | ENSG00000197181.7 | 3.597E-14 | 0 | -777 | gtex_brain_putamen_basal |
| rs4871990 | 8 | 22132837 | PIWIL2 | ENSG00000197181.7 | 3.597E-14 | 0 | 27 | gtex_brain_putamen_basal |
| rs34010761 | 8 | 22132864 | PIWIL2 | ENSG00000197181.7 | 1.082E-6 | 0 | 54 | gtex_brain_putamen_basal |
| rs13259097 | 8 | 22133744 | PIWIL2 | ENSG00000197181.7 | 1.911E-10 | 0 | 934 | gtex_brain_putamen_basal |
| rs199863565 | 8 | 22134545 | PIWIL2 | ENSG00000197181.7 | 1.197E-6 | 0 | 1735 | gtex_brain_putamen_basal |
| rs6995167 | 8 | 22134546 | PIWIL2 | ENSG00000197181.7 | 2.265E-6 | 0 | 1736 | gtex_brain_putamen_basal |
| rs6557952 | 8 | 22134826 | PIWIL2 | ENSG00000197181.7 | 1.198E-6 | 0 | 2016 | gtex_brain_putamen_basal |
| rs59163347 | 8 | 22137515 | PIWIL2 | ENSG00000197181.7 | 7.373E-9 | 0 | 4705 | gtex_brain_putamen_basal |
| rs4871992 | 8 | 22146385 | PIWIL2 | ENSG00000197181.7 | 2.263E-7 | 0 | 13575 | gtex_brain_putamen_basal |
| rs4872463 | 8 | 22147333 | PIWIL2 | ENSG00000197181.7 | 1.119E-7 | 0 | 14523 | gtex_brain_putamen_basal |
| rs11779087 | 8 | 22148085 | PIWIL2 | ENSG00000197181.7 | 7.899E-8 | 0 | 15275 | gtex_brain_putamen_basal |
| rs67983141 | 8 | 22150851 | PIWIL2 | ENSG00000197181.7 | 3.437E-7 | 0 | 18041 | gtex_brain_putamen_basal |
| rs61115295 | 8 | 22152541 | PIWIL2 | ENSG00000197181.7 | 4.61E-8 | 0 | 19731 | gtex_brain_putamen_basal |
| rs68063696 | 8 | 22153236 | PIWIL2 | ENSG00000197181.7 | 7.833E-8 | 0 | 20426 | gtex_brain_putamen_basal |
| rs4872464 | 8 | 22153381 | PIWIL2 | ENSG00000197181.7 | 2.009E-8 | 0 | 20571 | gtex_brain_putamen_basal |
| rs11985017 | 8 | 22153648 | PIWIL2 | ENSG00000197181.7 | 3.213E-7 | 0 | 20838 | gtex_brain_putamen_basal |
| rs11998634 | 8 | 22153773 | PIWIL2 | ENSG00000197181.7 | 3.103E-11 | 0 | 20963 | gtex_brain_putamen_basal |
| rs4565458 | 8 | 22154133 | PIWIL2 | ENSG00000197181.7 | 7.903E-8 | 0 | 21323 | gtex_brain_putamen_basal |
| rs35536982 | 8 | 22155786 | PIWIL2 | ENSG00000197181.7 | 2.621E-11 | 0 | 22976 | gtex_brain_putamen_basal |
| rs7357478 | 8 | 22158150 | PIWIL2 | ENSG00000197181.7 | 8.782E-13 | 0 | 25340 | gtex_brain_putamen_basal |
| rs9644047 | 8 | 22158670 | PIWIL2 | ENSG00000197181.7 | 3.863E-11 | 0 | 25860 | gtex_brain_putamen_basal |
| rs397807885 | 8 | 22159239 | PIWIL2 | ENSG00000197181.7 | 1.685E-6 | 0 | 26429 | gtex_brain_putamen_basal |
| rs7834182 | 8 | 22163112 | PIWIL2 | ENSG00000197181.7 | 9.697E-7 | 0 | 30302 | gtex_brain_putamen_basal |
| rs12543697 | 8 | 22163331 | PIWIL2 | ENSG00000197181.7 | 1.006E-9 | 0 | 30521 | gtex_brain_putamen_basal |
| rs6993855 | 8 | 22163797 | PIWIL2 | ENSG00000197181.7 | 7.776E-8 | 0 | 30987 | gtex_brain_putamen_basal |
| rs4872466 | 8 | 22164201 | PIWIL2 | ENSG00000197181.7 | 4.492E-10 | 0 | 31391 | gtex_brain_putamen_basal |
| rs4510862 | 8 | 22164631 | PIWIL2 | ENSG00000197181.7 | 7.323E-10 | 0 | 31821 | gtex_brain_putamen_basal |
| rs13257108 | 8 | 22165043 | PIWIL2 | ENSG00000197181.7 | 9.015E-7 | 0 | 32233 | gtex_brain_putamen_basal |
| rs13270663 | 8 | 22166436 | PIWIL2 | ENSG00000197181.7 | 4.486E-10 | 0 | 33626 | gtex_brain_putamen_basal |
| rs4266653 | 8 | 22169087 | PIWIL2 | ENSG00000197181.7 | 6.128E-8 | 0 | 36277 | gtex_brain_putamen_basal |
| rs4374997 | 8 | 22169326 | PIWIL2 | ENSG00000197181.7 | 2.543E-13 | 0 | 36516 | gtex_brain_putamen_basal |
| rs3923433 | 8 | 22169798 | PIWIL2 | ENSG00000197181.7 | 7.887E-8 | 0 | 36988 | gtex_brain_putamen_basal |
| rs3923439 | 8 | 22170079 | PIWIL2 | ENSG00000197181.7 | 7.887E-8 | 0 | 37269 | gtex_brain_putamen_basal |
| rs11135987 | 8 | 22173079 | PIWIL2 | ENSG00000197181.7 | 7.807E-8 | 0 | 40269 | gtex_brain_putamen_basal |
| rs11135989 | 8 | 22175368 | PIWIL2 | ENSG00000197181.7 | 5.814E-7 | 0 | 42558 | gtex_brain_putamen_basal |
| rs4242431 | 8 | 22175533 | PIWIL2 | ENSG00000197181.7 | 5.962E-12 | 0 | 42723 | gtex_brain_putamen_basal |
| rs4242432 | 8 | 22175567 | PIWIL2 | ENSG00000197181.7 | 4.388E-10 | 0 | 42757 | gtex_brain_putamen_basal |
| rs74598324 | 8 | 22177912 | PIWIL2 | ENSG00000197181.7 | 1.118E-6 | 0 | 45102 | gtex_brain_putamen_basal |
| rs4385468 | 8 | 22178742 | PIWIL2 | ENSG00000197181.7 | 2.431E-13 | 0 | 45932 | gtex_brain_putamen_basal |
| rs4872468 | 8 | 22179844 | PIWIL2 | ENSG00000197181.7 | 8.748E-7 | 0 | 47034 | gtex_brain_putamen_basal |
| rs9792127 | 8 | 22180334 | PIWIL2 | ENSG00000197181.7 | 1.107E-7 | 0 | 47524 | gtex_brain_putamen_basal |
| rs9792133 | 8 | 22180627 | PIWIL2 | ENSG00000197181.7 | 7.415E-10 | 0 | 47817 | gtex_brain_putamen_basal |
| rs9792345 | 8 | 22180724 | PIWIL2 | ENSG00000197181.7 | 2.254E-9 | 0 | 47914 | gtex_brain_putamen_basal |
| rs7826414 | 8 | 22181363 | PIWIL2 | ENSG00000197181.7 | 1.327E-9 | 0 | 48553 | gtex_brain_putamen_basal |
| rs7834063 | 8 | 22184881 | PIWIL2 | ENSG00000197181.7 | 5.319E-10 | 0 | 52071 | gtex_brain_putamen_basal |
| rs7012457 | 8 | 22197094 | PIWIL2 | ENSG00000197181.7 | 6.626E-10 | 0 | 64284 | gtex_brain_putamen_basal |
| rs34728679 | 8 | 22197352 | PIWIL2 | ENSG00000197181.7 | 6.624E-10 | 0 | 64542 | gtex_brain_putamen_basal |
| rs4556088 | 8 | 22198981 | PIWIL2 | ENSG00000197181.7 | 6.081E-12 | 0 | 66171 | gtex_brain_putamen_basal |
| rs11135995 | 8 | 22200148 | PIWIL2 | ENSG00000197181.7 | 7.908E-8 | 0 | 67338 | gtex_brain_putamen_basal |
| rs11779277 | 8 | 22200683 | PIWIL2 | ENSG00000197181.7 | 4.44E-8 | 0 | 67873 | gtex_brain_putamen_basal |
| rs7007895 | 8 | 22200983 | PIWIL2 | ENSG00000197181.7 | 5.875E-10 | 0 | 68173 | gtex_brain_putamen_basal |
| rs7003478 | 8 | 22201123 | PIWIL2 | ENSG00000197181.7 | 7.924E-8 | 0 | 68313 | gtex_brain_putamen_basal |
| rs35068739 | 8 | 22201719 | PIWIL2 | ENSG00000197181.7 | 8.035E-8 | 0 | 68909 | gtex_brain_putamen_basal |
| rs13260498 | 8 | 22202813 | PIWIL2 | ENSG00000197181.7 | 1.076E-11 | 0 | 70003 | gtex_brain_putamen_basal |
| rs4872473 | 8 | 22203184 | PIWIL2 | ENSG00000197181.7 | 2.954E-13 | 0 | 70374 | gtex_brain_putamen_basal |
| rs2404336 | 8 | 22203434 | PIWIL2 | ENSG00000197181.7 | 2.512E-13 | 0 | 70624 | gtex_brain_putamen_basal |
| rs13279181 | 8 | 22204306 | PIWIL2 | ENSG00000197181.7 | 7.287E-10 | 0 | 71496 | gtex_brain_putamen_basal |
| rs13252392 | 8 | 22204782 | PIWIL2 | ENSG00000197181.7 | 5.98E-7 | 0 | 71972 | gtex_brain_putamen_basal |
| rs4871994 | 8 | 22206038 | PIWIL2 | ENSG00000197181.7 | 8.715E-7 | 0 | 73228 | gtex_brain_putamen_basal |
| rs13255261 | 8 | 22206930 | PIWIL2 | ENSG00000197181.7 | 4.383E-7 | 0 | 74120 | gtex_brain_putamen_basal |
| rs13255264 | 8 | 22206932 | PIWIL2 | ENSG00000197181.7 | 1.07E-7 | 0 | 74122 | gtex_brain_putamen_basal |
| rs11783123 | 8 | 22208095 | PIWIL2 | ENSG00000197181.7 | 7.238E-10 | 0 | 75285 | gtex_brain_putamen_basal |
| rs11784154 | 8 | 22208592 | PIWIL2 | ENSG00000197181.7 | 7.194E-10 | 0 | 75782 | gtex_brain_putamen_basal |
| rs4872475 | 8 | 22208953 | PIWIL2 | ENSG00000197181.7 | 3.052E-8 | 0 | 76143 | gtex_brain_putamen_basal |
| rs4872476 | 8 | 22210234 | PIWIL2 | ENSG00000197181.7 | 7.185E-10 | 0 | 77424 | gtex_brain_putamen_basal |
| rs66554545 | 8 | 22211756 | PIWIL2 | ENSG00000197181.7 | 4.965E-10 | 0 | 78946 | gtex_brain_putamen_basal |
| rs59283125 | 8 | 22212311 | PIWIL2 | ENSG00000197181.7 | 6.888E-8 | 0 | 79501 | gtex_brain_putamen_basal |
| rs2290274 | 8 | 22214374 | PIWIL2 | ENSG00000197181.7 | 1.614E-7 | 0 | 81564 | gtex_brain_putamen_basal |
| rs11136002 | 8 | 22217082 | PIWIL2 | ENSG00000197181.7 | 3.774E-8 | 0 | 84272 | gtex_brain_putamen_basal |
| rs4872477 | 8 | 22217821 | PIWIL2 | ENSG00000197181.7 | 1.102E-10 | 0 | 85011 | gtex_brain_putamen_basal |
| rs13261289 | 8 | 22219807 | PIWIL2 | ENSG00000197181.7 | 2.69E-7 | 0 | 86997 | gtex_brain_putamen_basal |
| rs34528906 | 8 | 22220033 | PIWIL2 | ENSG00000197181.7 | 1.23E-7 | 0 | 87223 | gtex_brain_putamen_basal |
| rs36105277 | 8 | 22220051 | PIWIL2 | ENSG00000197181.7 | 2.019E-8 | 0 | 87241 | gtex_brain_putamen_basal |
| rs11777867 | 8 | 22221664 | PIWIL2 | ENSG00000197181.7 | 2.208E-12 | 0 | 88854 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0003676 | nucleic acid binding | IEA | - | |
| GO:0005515 | protein binding | IEA | - | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0007283 | spermatogenesis | IEA | - | |
| GO:0007128 | meiotic prophase I | IEA | - | |
| GO:0007275 | multicellular organismal development | IEA | - | |
| GO:0030154 | cell differentiation | IEA | - | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005737 | cytoplasm | IEA | - |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG DORSO VENTRAL AXIS FORMATION | 25 | 21 | All SZGR 2.0 genes in this pathway |
| PARENT MTOR SIGNALING UP | 567 | 375 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN APOPTOSIS BY DOXORUBICIN UP | 1142 | 669 | All SZGR 2.0 genes in this pathway |
| SANSOM APC TARGETS UP | 126 | 84 | All SZGR 2.0 genes in this pathway |
| MOREAUX MULTIPLE MYELOMA BY TACI UP | 412 | 249 | All SZGR 2.0 genes in this pathway |
| MARTINEZ RB1 TARGETS UP | 673 | 430 | All SZGR 2.0 genes in this pathway |
| MARTINEZ TP53 TARGETS DN | 593 | 372 | All SZGR 2.0 genes in this pathway |
| MARTINEZ RB1 AND TP53 TARGETS DN | 591 | 366 | All SZGR 2.0 genes in this pathway |
| MATZUK SPERMATOCYTE | 72 | 55 | All SZGR 2.0 genes in this pathway |
| CONRAD STEM CELL | 39 | 27 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN ES ICP WITH H3K4ME3 AND H3K27ME3 | 137 | 85 | All SZGR 2.0 genes in this pathway |
| FEVR CTNNB1 TARGETS DN | 553 | 343 | All SZGR 2.0 genes in this pathway |