Summary ?
DescriptionTHAP domain containing, apoptosis associated protein 1
Gene typeprotein-coding
Map location8p11.21
Pascal p-value0.029
Fetal beta1.153
DMG1 (# studies)

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AP2B1ADTB2 | AP105B | AP2-BETA | CLAPB1 | DKFZp781K0743adaptor-related protein complex 2, beta 1 subunitTwo-hybridBioGRID16189514 
C1orf35MGC4174 | MMTAG2chromosome 1 open reading frame 35Two-hybridBioGRID16189514 
DVL2-dishevelled, dsh homolog 2 (Drosophila)Two-hybridBioGRID16189514 
FXR2FMR1L2fragile X mental retardation, autosomal homolog 2Two-hybridBioGRID16189514 
GRINL1ADKFZp586F1918glutamate receptor, ionotropic, N-methyl D-aspartate-like 1ATwo-hybridBioGRID16189514 
NKAPFLJ22626NFKB activating proteinTwo-hybridBioGRID16189514 
NUP62DKFZp547L134 | FLJ20822 | FLJ43869 | IBSN | MGC841 | SNDI | p62nucleoporin 62kDaTwo-hybridBioGRID16189514 
PAWRPAR4 | Par-4PRKC, apoptosis, WT1, regulator-HPRD,BioGRID12717420 
PHF1MTF2L2 | PCL1 | PHF2PHD finger protein 1Two-hybridBioGRID16189514 
RALYLHNRPCL3RALY RNA binding protein-likeTwo-hybridBioGRID16189514 
STRBPDKFZp434N214 | FLJ11307 | FLJ14223 | FLJ14984 | ILF3L | MGC21529 | MGC3405 | SPNR | p74spermatid perinuclear RNA binding proteinTwo-hybridBioGRID16189514 
THAP1FLJ10477 | MGC33014THAP domain containing, apoptosis associated protein 1Two-hybridBioGRID16189514 
U2AF2U2AF65U2 small nuclear RNA auxiliary factor 2Two-hybridBioGRID16189514 
ZCCHC10FLJ20094zinc finger, CCHC domain containing 10Two-hybridBioGRID16189514 
ZNF408FLJ12827zinc finger protein 408Two-hybridBioGRID16189514 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278748All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL UP 584356All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS 988594All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 8P12 P11 AMPLICON 5732All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE DN 841431All SZGR 2.0 genes in this pathway
GREGORY SYNTHETIC LETHAL WITH IMATINIB 14583All SZGR 2.0 genes in this pathway