Summary ?
GeneID55191
SymbolNADSYN1
Synonyms-
DescriptionNAD synthetase 1
ReferenceMIM:608285|HGNC:HGNC:29832|Ensembl:ENSG00000172890|HPRD:16309|Vega:OTTHUMG00000167375
Gene typeprotein-coding
Map location11q13.4
Pascal p-value0.43
Sherlock p-value0.395
Fetal beta0.047
DMG1 (# studies)
eGeneCaudate basal ganglia
Cortex
Putamen basal ganglia

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg078641891171164265NADSYN11.32E-8-0.0075.27E-6DMG:Jaffe_2016

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs3687553831171146248NADSYN1ENSG00000172890.74.277E-70.01-17907gtex_brain_putamen_basal
rs127935301171161656NADSYN1ENSG00000172890.72.905E-60.01-2499gtex_brain_putamen_basal
rs115465091171162785NADSYN1ENSG00000172890.72.921E-60.01-1370gtex_brain_putamen_basal
rs20020641171163420NADSYN1ENSG00000172890.72.082E-60.01-735gtex_brain_putamen_basal
rs20020631171163476NADSYN1ENSG00000172890.72.973E-60.01-679gtex_brain_putamen_basal
rs116008601171164019NADSYN1ENSG00000172890.73.124E-60.01-136gtex_brain_putamen_basal
rs116066111171164046NADSYN1ENSG00000172890.73.616E-60.01-109gtex_brain_putamen_basal
rs116066121171164047NADSYN1ENSG00000172890.73.139E-60.01-108gtex_brain_putamen_basal
rs116066311171164121NADSYN1ENSG00000172890.73.046E-60.01-34gtex_brain_putamen_basal
rs127897511171164471NADSYN1ENSG00000172890.73.097E-60.01316gtex_brain_putamen_basal
rs127918711171164544NADSYN1ENSG00000172890.73.109E-60.01389gtex_brain_putamen_basal
rs17923151171165547NADSYN1ENSG00000172890.72.679E-60.011392gtex_brain_putamen_basal
rs79449261171165625NADSYN1ENSG00000172890.73.109E-60.011470gtex_brain_putamen_basal
rs127858781171167449NADSYN1ENSG00000172890.73.109E-60.013294gtex_brain_putamen_basal
rs49449581171168073NADSYN1ENSG00000172890.73.107E-60.013918gtex_brain_putamen_basal
rs49449591171168234NADSYN1ENSG00000172890.73.109E-60.014079gtex_brain_putamen_basal
rs127932241171168710NADSYN1ENSG00000172890.73.109E-60.014555gtex_brain_putamen_basal
rs127946681171168715NADSYN1ENSG00000172890.73.109E-60.014560gtex_brain_putamen_basal
rs22763601171169547NADSYN1ENSG00000172890.73.109E-60.015392gtex_brain_putamen_basal
rs127900101171170653NADSYN1ENSG00000172890.73.109E-60.016498gtex_brain_putamen_basal
rs128068441171170770NADSYN1ENSG00000172890.73.109E-60.016615gtex_brain_putamen_basal
rs128083681171170817NADSYN1ENSG00000172890.73.109E-60.016662gtex_brain_putamen_basal
rs127905581171170905NADSYN1ENSG00000172890.73.109E-60.016750gtex_brain_putamen_basal
rs112337471171171642NADSYN1ENSG00000172890.73.109E-60.017487gtex_brain_putamen_basal
rs344483461171171743NADSYN1ENSG00000172890.73.698E-60.017588gtex_brain_putamen_basal
rs116005691171173747NADSYN1ENSG00000172890.73.06E-60.019592gtex_brain_putamen_basal
rs16292201171174553NADSYN1ENSG00000172890.71.816E-60.0110398gtex_brain_putamen_basal
rs1429029431171175830NADSYN1ENSG00000172890.71.816E-60.0111675gtex_brain_putamen_basal
rs17922241171176141NADSYN1ENSG00000172890.71.816E-60.0111986gtex_brain_putamen_basal
rs17922261171176574NADSYN1ENSG00000172890.71.816E-60.0112419gtex_brain_putamen_basal
rs17903441171176897NADSYN1ENSG00000172890.71.816E-60.0112742gtex_brain_putamen_basal
rs17903431171177207NADSYN1ENSG00000172890.71.816E-60.0113052gtex_brain_putamen_basal
rs17922271171177412NADSYN1ENSG00000172890.71.816E-60.0113257gtex_brain_putamen_basal
rs17903411171177578NADSYN1ENSG00000172890.71.816E-60.0113423gtex_brain_putamen_basal
rs15401271171179038NADSYN1ENSG00000172890.71.816E-60.0114883gtex_brain_putamen_basal
rs17922291171179395NADSYN1ENSG00000172890.71.816E-60.0115240gtex_brain_putamen_basal
rs25110101171180783NADSYN1ENSG00000172890.71.816E-60.0116628gtex_brain_putamen_basal
rs122242051171180992NADSYN1ENSG00000172890.72.903E-60.0116837gtex_brain_putamen_basal
rs17922351171181473NADSYN1ENSG00000172890.71.816E-60.0117318gtex_brain_putamen_basal
rs16195771171181485NADSYN1ENSG00000172890.71.816E-60.0117330gtex_brain_putamen_basal
rs17922341171182018NADSYN1ENSG00000172890.71.816E-60.0117863gtex_brain_putamen_basal
rs17922331171182179NADSYN1ENSG00000172890.71.816E-60.0118024gtex_brain_putamen_basal
rs17903401171182589NADSYN1ENSG00000172890.71.813E-60.0118434gtex_brain_putamen_basal
rs17922311171182681NADSYN1ENSG00000172890.71.816E-60.0118526gtex_brain_putamen_basal
rs17903391171182761NADSYN1ENSG00000172890.71.816E-60.0118606gtex_brain_putamen_basal
rs44350281171183690NADSYN1ENSG00000172890.71.816E-60.0119535gtex_brain_putamen_basal
rs46160661171183846NADSYN1ENSG00000172890.71.816E-60.0119691gtex_brain_putamen_basal
rs44023221171184015NADSYN1ENSG00000172890.71.816E-60.0119860gtex_brain_putamen_basal
rs79351251171184190NADSYN1ENSG00000172890.73.109E-60.0120035gtex_brain_putamen_basal
rs22763581171184498NADSYN1ENSG00000172890.71.63E-60.0120343gtex_brain_putamen_basal
rs11230071171185357NADSYN1ENSG00000172890.71.834E-60.0121202gtex_brain_putamen_basal
rs7329341171186476NADSYN1ENSG00000172890.73.025E-60.0122321gtex_brain_putamen_basal
rs37940571171186744NADSYN1ENSG00000172890.71.819E-60.0122589gtex_brain_putamen_basal
rs20176861171187061NADSYN1ENSG00000172890.71.816E-60.0122906gtex_brain_putamen_basal
rs37940601171187679NADSYN1ENSG00000172890.72.942E-60.0123524gtex_brain_putamen_basal
rs128078271171203790NADSYN1ENSG00000172890.72.529E-60.0139635gtex_brain_putamen_basal
rs49450081171221248NADSYN1ENSG00000172890.72.658E-60.0157093gtex_brain_putamen_basal
rs116046421171222355NADSYN1ENSG00000172890.72.581E-60.0158200gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003952NAD+ synthase (glutamine-hydrolyzing) activityEXPglutamate (GO term level: 6)12547821 
GO:0003952NAD+ synthase (glutamine-hydrolyzing) activityIEAglutamate (GO term level: 6)-
GO:0000166nucleotide bindingIEA-
GO:0005515protein bindingIPI15231747 
GO:0005524ATP bindingIEA-
GO:0016810hydrolase activity, acting on carbon-nitrogen (but not peptide) bondsIEA-
GO:0016874ligase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0009435NAD biosynthetic processIEA-
GO:0006807nitrogen compound metabolic processIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolEXP12547821 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG NICOTINATE AND NICOTINAMIDE METABOLISM 2416All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF VITAMINS AND COFACTORS 5136All SZGR 2.0 genes in this pathway
PARENT MTOR SIGNALING UP 567375All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN 663425All SZGR 2.0 genes in this pathway
BASAKI YBX1 TARGETS DN 384230All SZGR 2.0 genes in this pathway
WANG CLIM2 TARGETS UP 269146All SZGR 2.0 genes in this pathway
WAMUNYOKOLI OVARIAN CANCER LMP UP 265158All SZGR 2.0 genes in this pathway
KOYAMA SEMA3B TARGETS UP 292168All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS 988594All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 11Q12 Q14 AMPLICON 15893All SZGR 2.0 genes in this pathway
MENSE HYPOXIA UP 9871All SZGR 2.0 genes in this pathway
MOREAUX MULTIPLE MYELOMA BY TACI DN 172107All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS LATE PROGENITOR 544307All SZGR 2.0 genes in this pathway
MEDINA SMARCA4 TARGETS 4429All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 1 528324All SZGR 2.0 genes in this pathway
HELLER SILENCED BY METHYLATION UP 282183All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL DN 701446All SZGR 2.0 genes in this pathway
BHAT ESR1 TARGETS VIA AKT1 UP 281183All SZGR 2.0 genes in this pathway