Summary ?
GeneID55226
SymbolNAT10
SynonymsALP|NET43
DescriptionN-acetyltransferase 10
ReferenceMIM:609221|HGNC:HGNC:29830|Ensembl:ENSG00000135372|HPRD:10964|Vega:OTTHUMG00000166249
Gene typeprotein-coding
Map location11p13
Pascal p-value0.002
Sherlock p-value0.626
Fetal beta-0.067
DMG2 (# studies)
eGenePutamen basal ganglia
Myers' cis & trans
Meta
SupportAscano FMRP targets

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 3
DMG:vanEijk_2014Genome-wide DNA methylation analysisThis dataset includes 432 differentially methylated CpG sites corresponding to 391 unique transcripts between schizophrenia patients (n=260) and unaffected controls (n=250). 3

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg258640421134127291NAT101.37E-8-0.0135.39E-6DMG:Jaffe_2016
cg093587251133914088NAT108.63E-64.726DMG:vanEijk_2014
cg244536641133758413NAT100.0012.324DMG:vanEijk_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs12677942chr831539941NAT10552260.18trans
rs2869061134660659NAT10ENSG00000135372.41.11097E-60.01533510gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
GLTPD10.930.94
LRFN10.920.93
LRRC4B0.920.93
EPN10.890.90
AC084125.10.890.90
HGS0.880.90
FAM116B0.880.90
ZBTB450.880.90
AC011471.10.880.90
AGPAT10.880.89
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.31-0.67-0.67
AF347015.27-0.66-0.68
AF347015.21-0.66-0.74
MT-CO2-0.66-0.67
AF347015.8-0.65-0.67
AF347015.33-0.64-0.64
MT-CYB-0.64-0.65
AF347015.15-0.60-0.62
NOSTRIN-0.60-0.64
COPZ2-0.60-0.62

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
ONKEN UVEAL MELANOMA UP 783507All SZGR 2.0 genes in this pathway
LOCKWOOD AMPLIFIED IN LUNG CANCER 214139All SZGR 2.0 genes in this pathway
RICKMAN TUMOR DIFFERENTIATED MODERATELY VS POORLY UP 12171All SZGR 2.0 genes in this pathway
RICKMAN METASTASIS UP 344180All SZGR 2.0 genes in this pathway
MANALO HYPOXIA DN 289166All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 1 528324All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES UP 605377All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103714All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN 882538All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN 1080713All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D 882506All SZGR 2.0 genes in this pathway