Gene Page: CCDC25
Summary ?
| GeneID | 55246 |
| Symbol | CCDC25 |
| Synonyms | - |
| Description | coiled-coil domain containing 25 |
| Reference | HGNC:HGNC:25591|Ensembl:ENSG00000147419|HPRD:07705|Vega:OTTHUMG00000132173 |
| Gene type | protein-coding |
| Map location | 8p21.1 |
| Pascal p-value | 0.027 |
| Sherlock p-value | 0.908 |
| Fetal beta | -1.801 |
| eGene | Caudate basal ganglia Cerebellar Hemisphere Cerebellum Frontal Cortex BA9 Nucleus accumbens basal ganglia Putamen basal ganglia Myers' cis & trans Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| GSMA_I | Genome scan meta-analysis | Psr: 0.031 | |
| GSMA_IIA | Genome scan meta-analysis (All samples) | Psr: 0.03086 | |
| GSMA_IIE | Genome scan meta-analysis (European-ancestry samples) | Psr: 0.00057 | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs17503497 | chr8 | 28091065 | CCDC25 | 55246 | 0.02 | cis | ||
| rs1563940 | chr8 | 28124554 | CCDC25 | 55246 | 0.14 | cis | ||
| rs1563943 | chr8 | 28145648 | CCDC25 | 55246 | 0.03 | cis | ||
| rs34604632 | 8 | 27581031 | CCDC25 | ENSG00000147419.12 | 3.487E-6 | 0 | 49139 | gtex_brain_putamen_basal |
| rs7828682 | 8 | 27581508 | CCDC25 | ENSG00000147419.12 | 1.308E-8 | 0 | 48662 | gtex_brain_putamen_basal |
| rs28692838 | 8 | 27581771 | CCDC25 | ENSG00000147419.12 | 1.308E-8 | 0 | 48399 | gtex_brain_putamen_basal |
| rs13259826 | 8 | 27582025 | CCDC25 | ENSG00000147419.12 | 1.32E-8 | 0 | 48145 | gtex_brain_putamen_basal |
| rs4323431 | 8 | 27584334 | CCDC25 | ENSG00000147419.12 | 2.825E-6 | 0 | 45836 | gtex_brain_putamen_basal |
| rs7465373 | 8 | 27586427 | CCDC25 | ENSG00000147419.12 | 7.674E-8 | 0 | 43743 | gtex_brain_putamen_basal |
| rs2004539 | 8 | 27587105 | CCDC25 | ENSG00000147419.12 | 1.004E-7 | 0 | 43065 | gtex_brain_putamen_basal |
| rs17385236 | 8 | 27587944 | CCDC25 | ENSG00000147419.12 | 1.929E-6 | 0 | 42226 | gtex_brain_putamen_basal |
| rs2010776 | 8 | 27590027 | CCDC25 | ENSG00000147419.12 | 2.297E-7 | 0 | 40143 | gtex_brain_putamen_basal |
| rs9797 | 8 | 27591849 | CCDC25 | ENSG00000147419.12 | 2.365E-6 | 0 | 38321 | gtex_brain_putamen_basal |
| rs13273652 | 8 | 27595100 | CCDC25 | ENSG00000147419.12 | 2.365E-6 | 0 | 35070 | gtex_brain_putamen_basal |
| rs28460356 | 8 | 27595365 | CCDC25 | ENSG00000147419.12 | 2.365E-6 | 0 | 34805 | gtex_brain_putamen_basal |
| rs34636629 | 8 | 27598042 | CCDC25 | ENSG00000147419.12 | 9.25E-7 | 0 | 32128 | gtex_brain_putamen_basal |
| rs7825085 | 8 | 27598300 | CCDC25 | ENSG00000147419.12 | 2.365E-6 | 0 | 31870 | gtex_brain_putamen_basal |
| rs12334989 | 8 | 27600802 | CCDC25 | ENSG00000147419.12 | 2.376E-6 | 0 | 29368 | gtex_brain_putamen_basal |
| rs13280942 | 8 | 27602480 | CCDC25 | ENSG00000147419.12 | 1.258E-7 | 0 | 27690 | gtex_brain_putamen_basal |
| rs17477326 | 8 | 27603200 | CCDC25 | ENSG00000147419.12 | 1.258E-7 | 0 | 26970 | gtex_brain_putamen_basal |
| rs62498015 | 8 | 27603227 | CCDC25 | ENSG00000147419.12 | 5.097E-8 | 0 | 26943 | gtex_brain_putamen_basal |
| rs10103758 | 8 | 27603266 | CCDC25 | ENSG00000147419.12 | 2.365E-6 | 0 | 26904 | gtex_brain_putamen_basal |
| rs17477565 | 8 | 27608179 | CCDC25 | ENSG00000147419.12 | 1.258E-7 | 0 | 21991 | gtex_brain_putamen_basal |
| rs55663317 | 8 | 27608269 | CCDC25 | ENSG00000147419.12 | 1.258E-7 | 0 | 21901 | gtex_brain_putamen_basal |
| rs725361 | 8 | 27609538 | CCDC25 | ENSG00000147419.12 | 2.365E-6 | 0 | 20632 | gtex_brain_putamen_basal |
| rs6993868 | 8 | 27613012 | CCDC25 | ENSG00000147419.12 | 5.135E-8 | 0 | 17158 | gtex_brain_putamen_basal |
| rs13267051 | 8 | 27613316 | CCDC25 | ENSG00000147419.12 | 2.068E-7 | 0 | 16854 | gtex_brain_putamen_basal |
| rs4732745 | 8 | 27613967 | CCDC25 | ENSG00000147419.12 | 3.674E-7 | 0 | 16203 | gtex_brain_putamen_basal |
| rs17477830 | 8 | 27614595 | CCDC25 | ENSG00000147419.12 | 3.684E-7 | 0 | 15575 | gtex_brain_putamen_basal |
| rs56228913 | 8 | 27616585 | CCDC25 | ENSG00000147419.12 | 4.618E-7 | 0 | 13585 | gtex_brain_putamen_basal |
| rs17478040 | 8 | 27617875 | CCDC25 | ENSG00000147419.12 | 1.214E-6 | 0 | 12295 | gtex_brain_putamen_basal |
| rs10110224 | 8 | 27617978 | CCDC25 | ENSG00000147419.12 | 1.584E-7 | 0 | 12192 | gtex_brain_putamen_basal |
| rs13265718 | 8 | 27618198 | CCDC25 | ENSG00000147419.12 | 1.214E-6 | 0 | 11972 | gtex_brain_putamen_basal |
| rs10105019 | 8 | 27621127 | CCDC25 | ENSG00000147419.12 | 8.046E-7 | 0 | 9043 | gtex_brain_putamen_basal |
| rs13266988 | 8 | 27621774 | CCDC25 | ENSG00000147419.12 | 1.226E-6 | 0 | 8396 | gtex_brain_putamen_basal |
| rs10102309 | 8 | 27623209 | CCDC25 | ENSG00000147419.12 | 1.598E-7 | 0 | 6961 | gtex_brain_putamen_basal |
| rs17478353 | 8 | 27623295 | CCDC25 | ENSG00000147419.12 | 1.228E-6 | 0 | 6875 | gtex_brain_putamen_basal |
| rs17478366 | 8 | 27623549 | CCDC25 | ENSG00000147419.12 | 1.228E-6 | 0 | 6621 | gtex_brain_putamen_basal |
| rs17387237 | 8 | 27624163 | CCDC25 | ENSG00000147419.12 | 1.23E-6 | 0 | 6007 | gtex_brain_putamen_basal |
| rs12155559 | 8 | 27624525 | CCDC25 | ENSG00000147419.12 | 1.23E-6 | 0 | 5645 | gtex_brain_putamen_basal |
| rs10091671 | 8 | 27624940 | CCDC25 | ENSG00000147419.12 | 1.814E-7 | 0 | 5230 | gtex_brain_putamen_basal |
| rs13262948 | 8 | 27625201 | CCDC25 | ENSG00000147419.12 | 1.23E-6 | 0 | 4969 | gtex_brain_putamen_basal |
| rs10097446 | 8 | 27625974 | CCDC25 | ENSG00000147419.12 | 1.094E-7 | 0 | 4196 | gtex_brain_putamen_basal |
| rs10093956 | 8 | 27628886 | CCDC25 | ENSG00000147419.12 | 3.038E-8 | 0 | 1284 | gtex_brain_putamen_basal |
| rs7842666 | 8 | 27630152 | CCDC25 | ENSG00000147419.12 | 3.038E-8 | 0 | 18 | gtex_brain_putamen_basal |
| rs34876489 | 8 | 27630231 | CCDC25 | ENSG00000147419.12 | 4.467E-7 | 0 | -61 | gtex_brain_putamen_basal |
| rs35767880 | 8 | 27630243 | CCDC25 | ENSG00000147419.12 | 1.23E-6 | 0 | -73 | gtex_brain_putamen_basal |
| rs17478513 | 8 | 27631384 | CCDC25 | ENSG00000147419.12 | 1.23E-6 | 0 | -1214 | gtex_brain_putamen_basal |
| rs1841311 | 8 | 27631630 | CCDC25 | ENSG00000147419.12 | 3.112E-8 | 0 | -1460 | gtex_brain_putamen_basal |
| rs1841310 | 8 | 27631647 | CCDC25 | ENSG00000147419.12 | 1.23E-6 | 0 | -1477 | gtex_brain_putamen_basal |
| rs35430328 | 8 | 27631990 | CCDC25 | ENSG00000147419.12 | 1.23E-6 | 0 | -1820 | gtex_brain_putamen_basal |
| rs961334 | 8 | 27632829 | CCDC25 | ENSG00000147419.12 | 4.196E-7 | 0 | -2659 | gtex_brain_putamen_basal |
| rs17387538 | 8 | 27635989 | CCDC25 | ENSG00000147419.12 | 1.23E-6 | 0 | -5819 | gtex_brain_putamen_basal |
| rs35683471 | 8 | 27636729 | CCDC25 | ENSG00000147419.12 | 1.23E-6 | 0 | -6559 | gtex_brain_putamen_basal |
| rs35594916 | 8 | 27638585 | CCDC25 | ENSG00000147419.12 | 5.387E-7 | 0 | -8415 | gtex_brain_putamen_basal |
| rs34858968 | 8 | 27640189 | CCDC25 | ENSG00000147419.12 | 1.23E-6 | 0 | -10019 | gtex_brain_putamen_basal |
| rs4732749 | 8 | 27640600 | CCDC25 | ENSG00000147419.12 | 1.233E-6 | 0 | -10430 | gtex_brain_putamen_basal |
| rs4732750 | 8 | 27644513 | CCDC25 | ENSG00000147419.12 | 4.196E-7 | 0 | -14343 | gtex_brain_putamen_basal |
| rs13250379 | 8 | 27651795 | CCDC25 | ENSG00000147419.12 | 1.23E-6 | 0 | -21625 | gtex_brain_putamen_basal |
| rs35102495 | 8 | 27652358 | CCDC25 | ENSG00000147419.12 | 1.23E-6 | 0 | -22188 | gtex_brain_putamen_basal |
| rs35117969 | 8 | 27657459 | CCDC25 | ENSG00000147419.12 | 1.23E-6 | 0 | -27289 | gtex_brain_putamen_basal |
| rs11136008 | 8 | 27658654 | CCDC25 | ENSG00000147419.12 | 1.23E-6 | 0 | -28484 | gtex_brain_putamen_basal |
| rs17479454 | 8 | 27668726 | CCDC25 | ENSG00000147419.12 | 1.398E-6 | 0 | -38556 | gtex_brain_putamen_basal |
| rs35386738 | 8 | 27669686 | CCDC25 | ENSG00000147419.12 | 1.23E-6 | 0 | -39516 | gtex_brain_putamen_basal |
| rs34461536 | 8 | 27670687 | CCDC25 | ENSG00000147419.12 | 1.23E-6 | 0 | -40517 | gtex_brain_putamen_basal |
| rs34633208 | 8 | 27675626 | CCDC25 | ENSG00000147419.12 | 1.214E-6 | 0 | -45456 | gtex_brain_putamen_basal |
| rs34173549 | 8 | 27678842 | CCDC25 | ENSG00000147419.12 | 1.23E-6 | 0 | -48672 | gtex_brain_putamen_basal |
| rs35921602 | 8 | 27687811 | CCDC25 | ENSG00000147419.12 | 8.382E-7 | 0 | -57641 | gtex_brain_putamen_basal |
| rs4732767 | 8 | 27693769 | CCDC25 | ENSG00000147419.12 | 7.852E-7 | 0 | -63599 | gtex_brain_putamen_basal |
| rs66482085 | 8 | 27694704 | CCDC25 | ENSG00000147419.12 | 7.789E-7 | 0 | -64534 | gtex_brain_putamen_basal |
| rs1551720 | 8 | 27698237 | CCDC25 | ENSG00000147419.12 | 1.023E-6 | 0 | -68067 | gtex_brain_putamen_basal |
| rs13255966 | 8 | 27699353 | CCDC25 | ENSG00000147419.12 | 1.042E-6 | 0 | -69183 | gtex_brain_putamen_basal |
| rs11136012 | 8 | 27699715 | CCDC25 | ENSG00000147419.12 | 1.867E-8 | 0 | -69545 | gtex_brain_putamen_basal |
| rs11136013 | 8 | 27700045 | CCDC25 | ENSG00000147419.12 | 4.992E-7 | 0 | -69875 | gtex_brain_putamen_basal |
| rs4466359 | 8 | 27705878 | CCDC25 | ENSG00000147419.12 | 1.28E-6 | 0 | -75708 | gtex_brain_putamen_basal |
| rs4466360 | 8 | 27705879 | CCDC25 | ENSG00000147419.12 | 1.28E-6 | 0 | -75709 | gtex_brain_putamen_basal |
| rs6991207 | 8 | 27706063 | CCDC25 | ENSG00000147419.12 | 2.9E-6 | 0 | -75893 | gtex_brain_putamen_basal |
| rs6987396 | 8 | 27706211 | CCDC25 | ENSG00000147419.12 | 2.8E-6 | 0 | -76041 | gtex_brain_putamen_basal |
| rs7004847 | 8 | 27706212 | CCDC25 | ENSG00000147419.12 | 2.124E-6 | 0 | -76042 | gtex_brain_putamen_basal |
| rs6987535 | 8 | 27706288 | CCDC25 | ENSG00000147419.12 | 2.9E-6 | 0 | -76118 | gtex_brain_putamen_basal |
| rs7006117 | 8 | 27706333 | CCDC25 | ENSG00000147419.12 | 2.9E-6 | 0 | -76163 | gtex_brain_putamen_basal |
| rs6991899 | 8 | 27706507 | CCDC25 | ENSG00000147419.12 | 2.9E-6 | 0 | -76337 | gtex_brain_putamen_basal |
| rs6992026 | 8 | 27706535 | CCDC25 | ENSG00000147419.12 | 2.9E-6 | 0 | -76365 | gtex_brain_putamen_basal |
| rs10110505 | 8 | 27707078 | CCDC25 | ENSG00000147419.12 | 2.9E-6 | 0 | -76908 | gtex_brain_putamen_basal |
| rs10113647 | 8 | 27707265 | CCDC25 | ENSG00000147419.12 | 2.9E-6 | 0 | -77095 | gtex_brain_putamen_basal |
| rs1380679 | 8 | 27707899 | CCDC25 | ENSG00000147419.12 | 2.9E-6 | 0 | -77729 | gtex_brain_putamen_basal |
| rs1380680 | 8 | 27707954 | CCDC25 | ENSG00000147419.12 | 2.9E-6 | 0 | -77784 | gtex_brain_putamen_basal |
| rs4732770 | 8 | 27708284 | CCDC25 | ENSG00000147419.12 | 2.9E-6 | 0 | -78114 | gtex_brain_putamen_basal |
| rs4732772 | 8 | 27708617 | CCDC25 | ENSG00000147419.12 | 2.9E-6 | 0 | -78447 | gtex_brain_putamen_basal |
| rs199505449 | 8 | 27708924 | CCDC25 | ENSG00000147419.12 | 1.702E-6 | 0 | -78754 | gtex_brain_putamen_basal |
| rs8180891 | 8 | 27708928 | CCDC25 | ENSG00000147419.12 | 8.375E-7 | 0 | -78758 | gtex_brain_putamen_basal |
| rs10093673 | 8 | 27709242 | CCDC25 | ENSG00000147419.12 | 2.9E-6 | 0 | -79072 | gtex_brain_putamen_basal |
| rs2236 | 8 | 27710100 | CCDC25 | ENSG00000147419.12 | 2.9E-6 | 0 | -79930 | gtex_brain_putamen_basal |
| rs7838272 | 8 | 27710261 | CCDC25 | ENSG00000147419.12 | 2.9E-6 | 0 | -80091 | gtex_brain_putamen_basal |
| rs4585704 | 8 | 27710502 | CCDC25 | ENSG00000147419.12 | 2.9E-6 | 0 | -80332 | gtex_brain_putamen_basal |
| rs6558019 | 8 | 27710794 | CCDC25 | ENSG00000147419.12 | 2.9E-6 | 0 | -80624 | gtex_brain_putamen_basal |
| rs13251432 | 8 | 27711048 | CCDC25 | ENSG00000147419.12 | 2.9E-6 | 0 | -80878 | gtex_brain_putamen_basal |
| rs13276502 | 8 | 27711232 | CCDC25 | ENSG00000147419.12 | 2.9E-6 | 0 | -81062 | gtex_brain_putamen_basal |
| rs4732773 | 8 | 27711338 | CCDC25 | ENSG00000147419.12 | 2.9E-6 | 0 | -81168 | gtex_brain_putamen_basal |
| rs4732774 | 8 | 27711377 | CCDC25 | ENSG00000147419.12 | 2.9E-6 | 0 | -81207 | gtex_brain_putamen_basal |
| rs4732776 | 8 | 27711673 | CCDC25 | ENSG00000147419.12 | 2.9E-6 | 0 | -81503 | gtex_brain_putamen_basal |
| rs4732609 | 8 | 27711793 | CCDC25 | ENSG00000147419.12 | 2.9E-6 | 0 | -81623 | gtex_brain_putamen_basal |
| rs7817174 | 8 | 27712226 | CCDC25 | ENSG00000147419.12 | 2.9E-6 | 0 | -82056 | gtex_brain_putamen_basal |
| rs7813468 | 8 | 27712236 | CCDC25 | ENSG00000147419.12 | 2.9E-6 | 0 | -82066 | gtex_brain_putamen_basal |
| rs7817205 | 8 | 27712292 | CCDC25 | ENSG00000147419.12 | 2.896E-6 | 0 | -82122 | gtex_brain_putamen_basal |
| rs12549445 | 8 | 27712672 | CCDC25 | ENSG00000147419.12 | 2.9E-6 | 0 | -82502 | gtex_brain_putamen_basal |
| rs11782093 | 8 | 27712744 | CCDC25 | ENSG00000147419.12 | 2.9E-6 | 0 | -82574 | gtex_brain_putamen_basal |
| rs11782095 | 8 | 27712758 | CCDC25 | ENSG00000147419.12 | 2.9E-6 | 0 | -82588 | gtex_brain_putamen_basal |
| rs11136016 | 8 | 27712875 | CCDC25 | ENSG00000147419.12 | 2.9E-6 | 0 | -82705 | gtex_brain_putamen_basal |
| rs7833802 | 8 | 27713037 | CCDC25 | ENSG00000147419.12 | 2.383E-6 | 0 | -82867 | gtex_brain_putamen_basal |
| rs7833806 | 8 | 27713042 | CCDC25 | ENSG00000147419.12 | 2.906E-6 | 0 | -82872 | gtex_brain_putamen_basal |
| rs7835072 | 8 | 27713167 | CCDC25 | ENSG00000147419.12 | 2.9E-6 | 0 | -82997 | gtex_brain_putamen_basal |
| rs7835073 | 8 | 27713170 | CCDC25 | ENSG00000147419.12 | 2.9E-6 | 0 | -83000 | gtex_brain_putamen_basal |
| rs7835364 | 8 | 27713351 | CCDC25 | ENSG00000147419.12 | 2.268E-6 | 0 | -83181 | gtex_brain_putamen_basal |
| rs7834391 | 8 | 27713426 | CCDC25 | ENSG00000147419.12 | 1.718E-6 | 0 | -83256 | gtex_brain_putamen_basal |
| rs11327253 | 8 | 27713443 | CCDC25 | ENSG00000147419.12 | 9.929E-7 | 0 | -83273 | gtex_brain_putamen_basal |
| rs11368355 | 8 | 27713446 | CCDC25 | ENSG00000147419.12 | 1.854E-6 | 0 | -83276 | gtex_brain_putamen_basal |
| rs6558020 | 8 | 27713648 | CCDC25 | ENSG00000147419.12 | 2.9E-6 | 0 | -83478 | gtex_brain_putamen_basal |
| rs7010741 | 8 | 27714179 | CCDC25 | ENSG00000147419.12 | 2.893E-6 | 0 | -84009 | gtex_brain_putamen_basal |
| rs898468 | 8 | 27714736 | CCDC25 | ENSG00000147419.12 | 2.887E-6 | 0 | -84566 | gtex_brain_putamen_basal |
| rs898467 | 8 | 27714922 | CCDC25 | ENSG00000147419.12 | 2.875E-6 | 0 | -84752 | gtex_brain_putamen_basal |
| rs4363153 | 8 | 27715284 | CCDC25 | ENSG00000147419.12 | 2.875E-6 | 0 | -85114 | gtex_brain_putamen_basal |
| rs4473993 | 8 | 27715393 | CCDC25 | ENSG00000147419.12 | 2.875E-6 | 0 | -85223 | gtex_brain_putamen_basal |
| rs4342548 | 8 | 27715573 | CCDC25 | ENSG00000147419.12 | 2.875E-6 | 0 | -85403 | gtex_brain_putamen_basal |
| rs4316109 | 8 | 27715660 | CCDC25 | ENSG00000147419.12 | 2.875E-6 | 0 | -85490 | gtex_brain_putamen_basal |
| rs4276641 | 8 | 27715687 | CCDC25 | ENSG00000147419.12 | 2.875E-6 | 0 | -85517 | gtex_brain_putamen_basal |
| rs4422735 | 8 | 27715717 | CCDC25 | ENSG00000147419.12 | 2.876E-6 | 0 | -85547 | gtex_brain_putamen_basal |
| rs34325366 | 8 | 27716025 | CCDC25 | ENSG00000147419.12 | 2.742E-6 | 0 | -85855 | gtex_brain_putamen_basal |
| rs7823922 | 8 | 27716308 | CCDC25 | ENSG00000147419.12 | 2.875E-6 | 0 | -86138 | gtex_brain_putamen_basal |
| rs7845428 | 8 | 27716353 | CCDC25 | ENSG00000147419.12 | 2.875E-6 | 0 | -86183 | gtex_brain_putamen_basal |
| rs7824054 | 8 | 27716355 | CCDC25 | ENSG00000147419.12 | 2.875E-6 | 0 | -86185 | gtex_brain_putamen_basal |
| rs201399994 | 8 | 27716355 | CCDC25 | ENSG00000147419.12 | 2.895E-6 | 0 | -86185 | gtex_brain_putamen_basal |
| rs7824383 | 8 | 27716601 | CCDC25 | ENSG00000147419.12 | 2.875E-6 | 0 | -86431 | gtex_brain_putamen_basal |
| rs7815494 | 8 | 27717089 | CCDC25 | ENSG00000147419.12 | 2.874E-6 | 0 | -86919 | gtex_brain_putamen_basal |
| rs7828733 | 8 | 27717136 | CCDC25 | ENSG00000147419.12 | 2.875E-6 | 0 | -86966 | gtex_brain_putamen_basal |
| rs12546118 | 8 | 27717160 | CCDC25 | ENSG00000147419.12 | 3.055E-6 | 0 | -86990 | gtex_brain_putamen_basal |
| rs10097776 | 8 | 27720025 | CCDC25 | ENSG00000147419.12 | 1.343E-6 | 0 | -89855 | gtex_brain_putamen_basal |
| rs2100759 | 8 | 27720309 | CCDC25 | ENSG00000147419.12 | 1.377E-6 | 0 | -90139 | gtex_brain_putamen_basal |
| rs898460 | 8 | 27720824 | CCDC25 | ENSG00000147419.12 | 8.82E-7 | 0 | -90654 | gtex_brain_putamen_basal |
| rs4732779 | 8 | 27721618 | CCDC25 | ENSG00000147419.12 | 2.9E-6 | 0 | -91448 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| SMC3 | 0.94 | 0.93 |
| SET | 0.94 | 0.90 |
| FAM76B | 0.94 | 0.92 |
| TAF1A | 0.93 | 0.89 |
| TOP2B | 0.93 | 0.92 |
| CEBPZ | 0.93 | 0.93 |
| CEP57 | 0.93 | 0.92 |
| CBX3 | 0.93 | 0.90 |
| ZNF227 | 0.93 | 0.90 |
| METTL14 | 0.93 | 0.91 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| HLA-F | -0.70 | -0.79 |
| AF347015.31 | -0.69 | -0.85 |
| AIFM3 | -0.69 | -0.77 |
| AF347015.27 | -0.68 | -0.84 |
| MT-CO2 | -0.68 | -0.86 |
| PTH1R | -0.68 | -0.77 |
| FBXO2 | -0.68 | -0.72 |
| TSC22D4 | -0.67 | -0.79 |
| AF347015.33 | -0.67 | -0.83 |
| MT-CYB | -0.67 | -0.85 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| DAVICIONI MOLECULAR ARMS VS ERMS DN | 182 | 111 | All SZGR 2.0 genes in this pathway |
| DAIRKEE TERT TARGETS UP | 380 | 213 | All SZGR 2.0 genes in this pathway |
| DOUGLAS BMI1 TARGETS DN | 314 | 188 | All SZGR 2.0 genes in this pathway |
| MARSON BOUND BY E2F4 UNSTIMULATED | 728 | 415 | All SZGR 2.0 genes in this pathway |
| BREDEMEYER RAG SIGNALING NOT VIA ATM UP | 62 | 29 | All SZGR 2.0 genes in this pathway |
| HAN SATB1 TARGETS UP | 395 | 249 | All SZGR 2.0 genes in this pathway |
Section VI. microRNA annotation
| miRNA family | Target position | miRNA ID | miRNA seq | ||
|---|---|---|---|---|---|
| UTR start | UTR end | Match method | |||
| miR-145 | 1004 | 1011 | 1A,m8 | hsa-miR-145 | GUCCAGUUUUCCCAGGAAUCCCUU |
| miR-421 | 1019 | 1025 | 1A | hsa-miR-421 | GGCCUCAUUAAAUGUUUGUUG |
- SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
- Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.