SZGR2

Summary ?

GeneID	5534
Symbol	PPP3R1
Synonyms	CALNB1\|CNB\|CNB1
Description	protein phosphatase 3 regulatory subunit B, alpha
Reference	MIM:601302\|HGNC:HGNC:9317\|Ensembl:ENSG00000221823\|HPRD:03195\|Vega:OTTHUMG00000129561
Gene type	protein-coding
Map location	2p15
Pascal p-value	0.013
Sherlock p-value	0.97
Fetal beta	-1.33
Support	INTRACELLULAR SIGNAL TRANSDUCTION Potential synaptic genes

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	Click to show details
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 1.4486

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
SLC27A4	0.91	0.90
ENO2	0.90	0.88
SV2A	0.88	0.86
KIAA0319L	0.87	0.84
MAGEE1	0.87	0.89
ABCG4	0.87	0.87
GBA2	0.86	0.83
GPI	0.86	0.83
ATP6AP1	0.86	0.85
ABCF3	0.86	0.82

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
AF347015.21	-0.64	-0.50
AF347015.31	-0.59	-0.46
MT-CO2	-0.57	-0.45
GNG11	-0.57	-0.50
AF347015.2	-0.56	-0.39
AF347015.8	-0.56	-0.42
AF347015.18	-0.55	-0.40
HIGD1B	-0.55	-0.43
C1orf54	-0.54	-0.52
AP002478.3	-0.54	-0.48

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005509	calcium ion binding	NAS		2558868
GO:0005515	protein binding	IPI		8524402
GO:0005517	calmodulin inhibitor activity	NAS		2558868
GO:0004723	calcium-dependent protein serine/threonine phosphatase activity	NAS		2558868
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0008633	activation of pro-apoptotic gene products	EXP		15231831
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005829	cytosol	EXP		10195903
GO:0005955	calcineurin complex	NAS		2558868

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG MAPK SIGNALING PATHWAY	267	205	All SZGR 2.0 genes in this pathway
KEGG CALCIUM SIGNALING PATHWAY	178	134	All SZGR 2.0 genes in this pathway
KEGG OOCYTE MEIOSIS	114	79	All SZGR 2.0 genes in this pathway
KEGG APOPTOSIS	88	62	All SZGR 2.0 genes in this pathway
KEGG WNT SIGNALING PATHWAY	151	112	All SZGR 2.0 genes in this pathway
KEGG AXON GUIDANCE	129	103	All SZGR 2.0 genes in this pathway
KEGG VEGF SIGNALING PATHWAY	76	53	All SZGR 2.0 genes in this pathway
KEGG NATURAL KILLER CELL MEDIATED CYTOTOXICITY	137	92	All SZGR 2.0 genes in this pathway
KEGG T CELL RECEPTOR SIGNALING PATHWAY	108	89	All SZGR 2.0 genes in this pathway
KEGG B CELL RECEPTOR SIGNALING PATHWAY	75	56	All SZGR 2.0 genes in this pathway
KEGG LONG TERM POTENTIATION	70	57	All SZGR 2.0 genes in this pathway
KEGG ALZHEIMERS DISEASE	169	110	All SZGR 2.0 genes in this pathway
KEGG AMYOTROPHIC LATERAL SCLEROSIS ALS	53	43	All SZGR 2.0 genes in this pathway
PID IL12 2PATHWAY	63	54	All SZGR 2.0 genes in this pathway
PID NFAT 3PATHWAY	54	47	All SZGR 2.0 genes in this pathway
PID TCR CALCIUM PATHWAY	29	23	All SZGR 2.0 genes in this pathway
PID CD8 TCR DOWNSTREAM PATHWAY	65	56	All SZGR 2.0 genes in this pathway
PID IL12 STAT4 PATHWAY	33	29	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR	920	449	All SZGR 2.0 genes in this pathway
REACTOME OPIOID SIGNALLING	78	56	All SZGR 2.0 genes in this pathway
REACTOME DARPP 32 EVENTS	25	20	All SZGR 2.0 genes in this pathway
REACTOME APOPTOSIS	148	94	All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF BH3 ONLY PROTEINS	17	12	All SZGR 2.0 genes in this pathway
REACTOME INTRINSIC PATHWAY FOR APOPTOSIS	30	21	All SZGR 2.0 genes in this pathway
WANG LMO4 TARGETS UP	372	227	All SZGR 2.0 genes in this pathway
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS YELLOW UP	32	25	All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN	1375	806	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN	855	609	All SZGR 2.0 genes in this pathway
KARAKAS TGFB1 SIGNALING	18	15	All SZGR 2.0 genes in this pathway
MATSUDA NATURAL KILLER DIFFERENTIATION	475	313	All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS MATURE CELL	293	160	All SZGR 2.0 genes in this pathway
LU AGING BRAIN DN	153	120	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN	1237	837	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 18HR UP	178	111	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE INCIPIENT DN	165	106	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 24HR UP	148	96	All SZGR 2.0 genes in this pathway
MATZUK MEIOTIC AND DNA REPAIR	39	26	All SZGR 2.0 genes in this pathway
ROME INSULIN TARGETS IN MUSCLE UP	442	263	All SZGR 2.0 genes in this pathway
SAKAI CHRONIC HEPATITIS VS LIVER CANCER UP	83	63	All SZGR 2.0 genes in this pathway
SASSON RESPONSE TO GONADOTROPHINS DN	87	66	All SZGR 2.0 genes in this pathway
SASSON RESPONSE TO FORSKOLIN DN	88	68	All SZGR 2.0 genes in this pathway
STAMBOLSKY TARGETS OF MUTATED TP53 UP	49	35	All SZGR 2.0 genes in this pathway
LU EZH2 TARGETS UP	295	155	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-101	2070	2076	1A	hsa-miR-101	UACAGUACUGUGAUAACUGAAG
miR-103/107	1505	1511	1A	hsa-miR-103^brain	AGCAGCAUUGUACAGGGCUAUGA
miR-103/107	1505	1511	1A	hsa-miR-107^brain	AGCAGCAUUGUACAGGGCUAUCA
miR-141/200a	154	160	1A	hsa-miR-141	UAACACUGUCUGGUAAAGAUGG
miR-141/200a	154	160	1A	hsa-miR-200a	UAACACUGUCUGGUAACGAUGU
miR-144	2069	2076	1A,m8	hsa-miR-144	UACAGUAUAGAUGAUGUACUAG
miR-17-5p/20/93.mr/106/519.d	193	200	1A,m8	hsa-miR-17-5p	CAAAGUGCUUACAGUGCAGGUAGU
				hsa-miR-20a^brain	UAAAGUGCUUAUAGUGCAGGUAG
				hsa-miR-106a	AAAAGUGCUUACAGUGCAGGUAGC
				hsa-miR-106b^SZ	UAAAGUGCUGACAGUGCAGAU
				hsa-miR-20b^SZ	CAAAGUGCUCAUAGUGCAGGUAG
				hsa-miR-519d	CAAAGUGCCUCCCUUUAGAGUGU
miR-181	2010	2016	m8	hsa-miR-181a^brain	AACAUUCAACGCUGUCGGUGAGU
				hsa-miR-181b^SZ	AACAUUCAUUGCUGUCGGUGGG
				hsa-miR-181c^brain	AACAUUCAACCUGUCGGUGAGU
				hsa-miR-181d^brain	AACAUUCAUUGUUGUCGGUGGGUU
miR-182	1642	1649	1A,m8	hsa-miR-182	UUUGGCAAUGGUAGAACUCACA
miR-190	230	236	1A	hsa-miR-190	UGAUAUGUUUGAUAUAUUAGGU
miR-194	1826	1832	1A	hsa-miR-194	UGUAACAGCAACUCCAUGUGGA
miR-204/211	248	255	1A,m8	hsa-miR-204^brain	UUCCCUUUGUCAUCCUAUGCCU
miR-204/211	248	255	1A,m8	hsa-miR-211	UUCCCUUUGUCAUCCUUCGCCU
miR-221/222	189	195	1A	hsa-miR-221^brain	AGCUACAUUGUCUGCUGGGUUUC
				hsa-miR-222^brain	AGCUACAUCUGGCUACUGGGUCUC
				hsa-miR-221^brain	AGCUACAUUGUCUGCUGGGUUUC
				hsa-miR-222^brain	AGCUACAUCUGGCUACUGGGUCUC
miR-26	386	392	m8	hsa-miR-26a^brain	UUCAAGUAAUCCAGGAUAGGC
miR-26	386	392	m8	hsa-miR-26b^SZ	UUCAAGUAAUUCAGGAUAGGUU
miR-27	110	116	1A	hsa-miR-27a^brain	UUCACAGUGGCUAAGUUCCGC
miR-27	110	116	1A	hsa-miR-27b^brain	UUCACAGUGGCUAAGUUCUGC
miR-30-5p	1607	1614	1A,m8	hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
miR-342	1528	1534	1A	hsa-miR-342^brain	UCUCACACAGAAAUCGCACCCGUC
miR-410	329	335	1A	hsa-miR-410	AAUAUAACACAGAUGGCCUGU
miR-433-3p	139	145	1A	hsa-miR-433^brain	AUCAUGAUGGGCUCCUCGGUGU
miR-485-3p	2073	2080	1A,m8	hsa-miR-485-3p	GUCAUACACGGCUCUCCUCUCU
miR-485-5p	135	141	1A	hsa-miR-485-5p	AGAGGCUGGCCGUGAUGAAUUC
miR-493-5p	486	492	1A	hsa-miR-493-5p	UUGUACAUGGUAGGCUUUCAUU
miR-495	1824	1830	1A	hsa-miR-495^brain	AAACAAACAUGGUGCACUUCUUU
miR-495	1824	1830	1A	hsa-miR-495^brain	AAACAAACAUGGUGCACUUCUUU
miR-496	319	325	1A	hsa-miR-496	AUUACAUGGCCAAUCUC
miR-496	319	325	1A	hsa-miR-496	AUUACAUGGCCAAUCUC
miR-505	2007	2013	1A	hsa-miR-505	GUCAACACUUGCUGGUUUCCUC
miR-543	1657	1663	1A	hsa-miR-543	AAACAUUCGCGGUGCACUUCU
miR-543	1657	1663	1A	hsa-miR-543	AAACAUUCGCGGUGCACUUCU
miR-93.hd/291-3p/294/295/302/372/373/520	192	198	m8	hsa-miR-93^brain	AAAGUGCUGUUCGUGCAGGUAG
				hsa-miR-302a	UAAGUGCUUCCAUGUUUUGGUGA
				hsa-miR-302b	UAAGUGCUUCCAUGUUUUAGUAG
				hsa-miR-302c	UAAGUGCUUCCAUGUUUCAGUGG
				hsa-miR-302d	UAAGUGCUUCCAUGUUUGAGUGU
				hsa-miR-372	AAAGUGCUGCGACAUUUGAGCGU
				hsa-miR-373	GAAGUGCUUCGAUUUUGGGGUGU
				hsa-miR-520e	AAAGUGCUUCCUUUUUGAGGG
				hsa-miR-520a	AAAGUGCUUCCCUUUGGACUGU
				hsa-miR-520b	AAAGUGCUUCCUUUUAGAGGG
				hsa-miR-520c	AAAGUGCUUCCUUUUAGAGGGUU
				hsa-miR-520d	AAAGUGCUUCUCUUUGGUGGGUU
miR-96	1643	1649	1A	hsa-miR-96^brain	UUUGGCACUAGCACAUUUUUGC
miR-96	1643	1649	1A	hsa-miR-96^brain	UUUGGCACUAGCACAUUUUUGC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: PPP3R1