SZGR2

Summary ?

GeneID	55388
Symbol	MCM10
Synonyms	CNA43\|DNA43\|PRO2249
Description	minichromosome maintenance 10 replication initiation factor
Reference	MIM:609357\|HGNC:HGNC:18043\|Ensembl:ENSG00000065328\|HPRD:11297\|Vega:OTTHUMG00000017694
Gene type	protein-coding
Map location	10p13
Pascal p-value	0.353
Fetal beta	4.35
DMG	1 (# studies)
eGene	Myers' cis & trans
Support	Ascano FMRP targets

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Wockner_2014	Genome-wide DNA methylation analysis	This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24).	1

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg26884570	10	13204110	MCM10	3.221E-4	-0.471	0.04	DMG:Wockner_2014

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	pvalue	qvalue	TSS distance	eQTL type
rs11124283	chr2	32767095	MCM10	55388		0.16		trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
CALCOCO2	MGC17318 \| NDP52	calcium binding and coiled-coil domain 2	Two-hybrid	BioGRID	16189514
CCDC5	FLJ21094 \| FLJ40084 \| HEI-C \| HsT1461	coiled-coil domain containing 5 (spindle associated)	-	HPRD	15232106
CCDC85B	DIPA	coiled-coil domain containing 85B	Two-hybrid	BioGRID	16189514
CCND1	BCL1 \| D11S287E \| PRAD1 \| U21B31	cyclin D1	-	HPRD	15232106
CCND3	-	cyclin D3	Affinity Capture-Western	BioGRID	16189514
CCND3	-	cyclin D3	-	HPRD	15232106
CDC45L	CDC45 \| CDC45L2 \| PORC-PI-1	CDC45 cell division cycle 45-like (S. cerevisiae)	-	HPRD	15232106
CDC6	CDC18L \| HsCDC18 \| HsCDC6	cell division cycle 6 homolog (S. cerevisiae)	-	HPRD	15232106
CDC7	CDC7L1 \| HsCDC7 \| Hsk1 \| MGC117361 \| MGC126237 \| MGC126238 \| huCDC7	cell division cycle 7 homolog (S. cerevisiae)	-	HPRD	15232106
CDK6	MGC59692 \| PLSTIRE \| STQTL11	cyclin-dependent kinase 6	-	HPRD	15232106
CEP70	BITE \| FLJ13036	centrosomal protein 70kDa	Two-hybrid	BioGRID	16189514
CEP72	FLJ10565 \| KIAA1519 \| MGC5307	centrosomal protein 72kDa	Two-hybrid	BioGRID	16189514
DPPA2	PESCRG1	developmental pluripotency associated 2	Two-hybrid	BioGRID	16189514
HOOK2	FLJ26218 \| HK2	hook homolog 2 (Drosophila)	Two-hybrid	BioGRID	16189514
KRT15	CK15 \| K15 \| K1CO	keratin 15	Two-hybrid	BioGRID	16189514
MCM2	BM28 \| CCNL1 \| CDCL1 \| D3S3194 \| KIAA0030 \| MGC10606 \| MITOTIN \| cdc19	minichromosome maintenance complex component 2	-	HPRD,BioGRID	11095689 \|15232106
MCM2	BM28 \| CCNL1 \| CDCL1 \| D3S3194 \| KIAA0030 \| MGC10606 \| MITOTIN \| cdc19	minichromosome maintenance complex component 2	-	HPRD	15232106
MCM3	HCC5 \| MGC1157 \| P1-MCM3 \| P1.h \| RLFB	minichromosome maintenance complex component 3	-	HPRD,BioGRID	11095689 \|15232106
MCM4	CDC21 \| CDC54 \| MGC33310 \| P1-CDC21 \| hCdc21	minichromosome maintenance complex component 4	-	HPRD,BioGRID	11095689
MCM6	MCG40308 \| Mis5 \| P105MCM	minichromosome maintenance complex component 6	in vitro in vivo Two-hybrid	BioGRID	11095689 \|16189514
MCM6	MCG40308 \| Mis5 \| P105MCM	minichromosome maintenance complex component 6	-	HPRD	11095689 \|15232106
MCM7	CDABP0042 \| CDC47 \| MCM2 \| P1.1-MCM3 \| P1CDC47 \| P85MCM \| PNAS-146	minichromosome maintenance complex component 7	-	HPRD,BioGRID	11095689 \|15232106
ORC2L	ORC2	origin recognition complex, subunit 2-like (yeast)	-	HPRD,BioGRID	11095689
ORC3L	LAT \| LATHEO \| ORC3	origin recognition complex, subunit 3-like (yeast)	-	HPRD	15232106
ORC4L	ORC4 \| ORC4P	origin recognition complex, subunit 4-like (yeast)	-	HPRD	15232106
RP4-691N24.1	FLJ11792 \| KIAA0980 \| NLP \| dJ691N24.1	ninein-like	Two-hybrid	BioGRID	16189514
TRIM37	KIAA0898 \| MUL \| POB1 \| TEF3	tripartite motif-containing 37	Two-hybrid	BioGRID	16189514
ZBTB43	ZBTB22B \| ZNF-X \| ZNF297B	zinc finger and BTB domain containing 43	Two-hybrid	BioGRID	16189514
ZBTB8	BOZF1 \| FLJ90065 \| MGC17919	zinc finger and BTB domain containing 8	Two-hybrid	BioGRID	16189514

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX	31	16	All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE	421	253	All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE MITOTIC	325	185	All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE CHECKPOINTS	124	70	All SZGR 2.0 genes in this pathway
REACTOME M G1 TRANSITION	81	45	All SZGR 2.0 genes in this pathway
REACTOME G1 S TRANSITION	112	63	All SZGR 2.0 genes in this pathway
REACTOME MITOTIC G1 G1 S PHASES	137	79	All SZGR 2.0 genes in this pathway
REACTOME MITOTIC M M G1 PHASES	172	98	All SZGR 2.0 genes in this pathway
REACTOME DNA REPLICATION	192	110	All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS	38	18	All SZGR 2.0 genes in this pathway
REACTOME G2 M CHECKPOINTS	45	23	All SZGR 2.0 genes in this pathway
BERTUCCI MEDULLARY VS DUCTAL BREAST CANCER UP	206	111	All SZGR 2.0 genes in this pathway
SOTIRIOU BREAST CANCER GRADE 1 VS 3 UP	151	84	All SZGR 2.0 genes in this pathway
BASAKI YBX1 TARGETS UP	290	177	All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER EARLY UP	430	232	All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP	1278	748	All SZGR 2.0 genes in this pathway
GRAHAM CML DIVIDING VS NORMAL QUIESCENT UP	181	101	All SZGR 2.0 genes in this pathway
GRAHAM NORMAL QUIESCENT VS NORMAL DIVIDING DN	87	49	All SZGR 2.0 genes in this pathway
BIDUS METASTASIS UP	214	134	All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN	1375	806	All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA UP	536	340	All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER BASAL VS LULMINAL	330	215	All SZGR 2.0 genes in this pathway
ROSTY CERVICAL CANCER PROLIFERATION CLUSTER	140	73	All SZGR 2.0 genes in this pathway
SHETH LIVER CANCER VS TXNIP LOSS PAM4	261	153	All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN	1024	594	All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS DN	637	377	All SZGR 2.0 genes in this pathway
WEI MYCN TARGETS WITH E BOX	795	478	All SZGR 2.0 genes in this pathway
GARCIA TARGETS OF FLI1 AND DAX1 DN	176	104	All SZGR 2.0 genes in this pathway
BENPORATH ES 1	379	235	All SZGR 2.0 genes in this pathway
BENPORATH ES 2	40	21	All SZGR 2.0 genes in this pathway
AMIT SERUM RESPONSE 480 MCF10A	39	20	All SZGR 2.0 genes in this pathway
GEORGES CELL CYCLE MIR192 TARGETS	62	46	All SZGR 2.0 genes in this pathway
GEORGES TARGETS OF MIR192 AND MIR215	893	528	All SZGR 2.0 genes in this pathway
ZHANG RESPONSE TO IKK INHIBITOR AND TNF DN	103	64	All SZGR 2.0 genes in this pathway
MORI IMMATURE B LYMPHOCYTE DN	90	55	All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 1 DN	169	102	All SZGR 2.0 genes in this pathway
LEE LIVER CANCER CIPROFIBRATE DN	66	43	All SZGR 2.0 genes in this pathway
LEE LIVER CANCER MYC TGFA DN	65	44	All SZGR 2.0 genes in this pathway
LEE LIVER CANCER ACOX1 DN	65	39	All SZGR 2.0 genes in this pathway
UEDA PERIFERAL CLOCK	169	111	All SZGR 2.0 genes in this pathway
MANALO HYPOXIA DN	289	166	All SZGR 2.0 genes in this pathway
LEE LIVER CANCER MYC E2F1 DN	64	38	All SZGR 2.0 genes in this pathway
LEE LIVER CANCER DENA DN	74	45	All SZGR 2.0 genes in this pathway
LEE LIVER CANCER E2F1 DN	64	42	All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA PR UP	45	20	All SZGR 2.0 genes in this pathway
ALCALAY AML BY NPM1 LOCALIZATION DN	184	132	All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 3	101	64	All SZGR 2.0 genes in this pathway
GAVIN FOXP3 TARGETS CLUSTER P6	91	44	All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED	1229	713	All SZGR 2.0 genes in this pathway
MARSON BOUND BY E2F4 UNSTIMULATED	728	415	All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS RESPONSIVE TO ESTROGEN DN	41	26	All SZGR 2.0 genes in this pathway
FUJII YBX1 TARGETS DN	202	132	All SZGR 2.0 genes in this pathway
SMID BREAST CANCER RELAPSE IN BRAIN UP	39	20	All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL UP	648	398	All SZGR 2.0 genes in this pathway
MUELLER PLURINET	299	189	All SZGR 2.0 genes in this pathway
GOLDRATH ANTIGEN RESPONSE	346	192	All SZGR 2.0 genes in this pathway
ICHIBA GRAFT VERSUS HOST DISEASE 35D DN	49	34	All SZGR 2.0 genes in this pathway
RUIZ TNC TARGETS DN	142	79	All SZGR 2.0 genes in this pathway
HOFFMANN LARGE TO SMALL PRE BII LYMPHOCYTE UP	163	102	All SZGR 2.0 genes in this pathway
LEE EARLY T LYMPHOCYTE UP	107	59	All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER POOR SURVIVAL A6	456	285	All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 36HR DN	185	116	All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 60HR DN	277	166	All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS DN	89	50	All SZGR 2.0 genes in this pathway
STEIN ESR1 TARGETS	85	55	All SZGR 2.0 genes in this pathway
KOBAYASHI EGFR SIGNALING 24HR DN	251	151	All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES UP	605	377	All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA PRONEURAL	177	132	All SZGR 2.0 genes in this pathway
WANG RESPONSE TO GSK3 INHIBITOR SB216763 DN	374	217	All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 6HR UP	229	149	All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR UP	324	193	All SZGR 2.0 genes in this pathway
OHGUCHI LIVER HNF4A TARGETS DN	149	85	All SZGR 2.0 genes in this pathway
BHAT ESR1 TARGETS NOT VIA AKT1 UP	211	131	All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN	882	538	All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION UP	570	339	All SZGR 2.0 genes in this pathway
SERVITJA LIVER HNF1A TARGETS DN	157	105	All SZGR 2.0 genes in this pathway

Gene Page: MCM10