SZGR2

Summary ?

GeneID	5549
Symbol	PRELP
Synonyms	MST161\|MSTP161\|SLRR2A
Description	proline/arginine-rich end leucine-rich repeat protein
Reference	MIM:601914\|HGNC:HGNC:9357\|Ensembl:ENSG00000188783\|HPRD:03556\|Vega:OTTHUMG00000035911
Gene type	protein-coding
Map location	1q32
Sherlock p-value	0.401
Fetal beta	-0.767
eGene	Putamen basal ganglia Myers' cis & trans Meta

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:GWASdb	Genome-wide Association Studies	GWASdb records for schizophrenia
CV:PGCnp	Genome-wide Association Study	GWAS

Section I. Genetics and epigenetics annotation

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	pvalue	qvalue	TSS distance	eQTL type
rs6668101	chr1	36099199	PRELP	5549		0.04		trans
rs1320385	chr1	54064468	PRELP	5549		0.06		trans
rs12036675	chr1	54066317	PRELP	5549		0.06		trans
rs17131472	chr1	91962966	PRELP	5549		0.01		trans
rs546975	chr1	91963738	PRELP	5549		0.14		trans
rs4953361	chr2	46598567	PRELP	5549		0.04		trans
rs1566993	chr2	117105059	PRELP	5549		0.07		trans
rs16825495	chr2	134234401	PRELP	5549		0		trans
rs7340510	chr2	134267368	PRELP	5549		0.1		trans
rs6730679	chr2	134282345	PRELP	5549		0.1		trans
rs2922180	chr3	125280472	PRELP	5549		0		trans
rs2976809	chr3	125451738	PRELP	5549		0.04		trans
rs2579326	chr4	72131304	PRELP	5549		0.03		trans
rs10050805	chr5	30805352	PRELP	5549		0.1		trans
rs317971	chr5	66688724	PRELP	5549		0		trans
rs248049	chr5	126489320	PRELP	5549		0.01		trans
rs17135501	chr6	2704474	PRELP	5549		0.19		trans
rs17135521	chr6	2707631	PRELP	5549		0.19		trans
snp_a-1787926		0	PRELP	5549		0.19		trans
rs7747217	chr6	3576943	PRELP	5549		0.07		trans
rs9381511	chr6	12931447	PRELP	5549		0		trans
rs16889690	chr6	34383787	PRELP	5549		0.18		trans
rs16889851	chr6	34401377	PRELP	5549		0.18		trans
rs6934246	chr6	35154494	PRELP	5549		6.311E-7		trans
rs16871832	chr6	44348256	PRELP	5549		0.05		trans
rs4711782	chr6	44363229	PRELP	5549		0.08		trans
rs6455226	chr6	67930295	PRELP	5549		0		trans
rs12056282	chr7	18882202	PRELP	5549		0.04		trans
rs10085826	chr7	42504690	PRELP	5549		0.05		trans
rs6970701	chr7	93087543	PRELP	5549		0.19		trans
rs12111850	chr7	93126467	PRELP	5549		0.19		trans
rs17165529	chr7	93144582	PRELP	5549		0.19		trans
rs7841407	chr8	9243427	PRELP	5549		0.15		trans
rs680372	chr8	36999626	PRELP	5549		0.01		trans
rs7081666	chr10	47673800	PRELP	5549		0.05		trans
rs11006556	chr10	61287609	PRELP	5549		0.01		trans
rs12573318	chr10	82909757	PRELP	5549		0.02		trans
rs1159612	chr10	85329057	PRELP	5549		4.348E-5		trans
rs17653230	chr10	120201621	PRELP	5549		0.14		trans
rs10502229	chr11	117979969	PRELP	5549		0.13		trans
rs11049036	chr12	27650292	PRELP	5549		0		trans
rs7303819	chr12	33990776	PRELP	5549		0		trans
rs10879027	chr12	70237156	PRELP	5549		0		trans
rs2802244	chr13	30081710	PRELP	5549		0.14		trans
rs2802243	chr13	30081748	PRELP	5549		0.14		trans
rs1457420	chr14	66958675	PRELP	5549		5.147E-4		trans
rs1872761	chr15	40003815	PRELP	5549		0.02		trans
rs17137819	chr16	5372534	PRELP	5549		0.01		trans
rs16958302	chr16	57647432	PRELP	5549		7.548E-6		trans
snp_a-1955963		0	PRELP	5549		0.06		trans
rs6034314	chr20	15852130	PRELP	5549		0.14		trans
rs4814410	chr20	15867428	PRELP	5549		0.06		trans
rs6095741	chr20	48666589	PRELP	5549		5.302E-4		trans
rs7265852	chr20	48823717	PRELP	5549		0		trans
rs5915713	chrX	4077883	PRELP	5549		2.306E-6		trans
rs5944334	chrX	26177987	PRELP	5549		7.087E-4		trans
rs5944341	chrX	26190706	PRELP	5549		7.087E-4		trans
rs5991662	chrX	43335796	PRELP	5549		0.01		trans
rs1545676	chrX	93530472	PRELP	5549		2.534E-9		trans
rs1540914	chrX	99840177	PRELP	5549		0.07		trans
rs5945924	chrX	102241590	PRELP	5549		0.2		trans
rs112904762	1	204003496	PRELP	ENSG00000188783.5	2.409E-6	0.03	558540	gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
DOCK3	0.93	0.94
KIAA1467	0.91	0.93
MADD	0.91	0.92
STXBP5	0.91	0.94
DLGAP1	0.91	0.93
PNMA2	0.90	0.91
RAPGEF2	0.90	0.91
HTT	0.90	0.90
BTBD9	0.90	0.90
WDR7	0.89	0.91

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
RAB34	-0.60	-0.66
AP002478.3	-0.58	-0.65
ACSF2	-0.58	-0.61
FXYD1	-0.57	-0.56
DBI	-0.57	-0.64
C1orf54	-0.57	-0.67
HIGD1B	-0.57	-0.59
TLCD1	-0.56	-0.56
C11orf67	-0.56	-0.60
SAT1	-0.56	-0.64

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
REACTOME KERATAN SULFATE BIOSYNTHESIS	26	18	All SZGR 2.0 genes in this pathway
REACTOME KERATAN SULFATE KERATIN METABOLISM	30	21	All SZGR 2.0 genes in this pathway
REACTOME KERATAN SULFATE DEGRADATION	11	7	All SZGR 2.0 genes in this pathway
REACTOME GLYCOSAMINOGLYCAN METABOLISM	111	69	All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF CARBOHYDRATES	247	154	All SZGR 2.0 genes in this pathway
LIU PROSTATE CANCER DN	481	290	All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER ADVANCED VS EARLY UP	175	120	All SZGR 2.0 genes in this pathway
JAEGER METASTASIS DN	258	141	All SZGR 2.0 genes in this pathway
PAPASPYRIDONOS UNSTABLE ATEROSCLEROTIC PLAQUE DN	43	29	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP	552	347	All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND SERUM DEPRIVATION UP	211	136	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN	1781	1082	All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 4 5WK DN	196	131	All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 6 7WK UP	197	135	All SZGR 2.0 genes in this pathway
KANG GIST WITH PDGFRA UP	50	27	All SZGR 2.0 genes in this pathway
PENG LEUCINE DEPRIVATION UP	142	93	All SZGR 2.0 genes in this pathway
AFFAR YY1 TARGETS DN	234	137	All SZGR 2.0 genes in this pathway
KANG IMMORTALIZED BY TERT DN	102	67	All SZGR 2.0 genes in this pathway
KAAB HEART ATRIUM VS VENTRICLE UP	249	170	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP	1691	1088	All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE BY 4NQO OR UV	63	44	All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE DN	195	135	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS UP	673	430	All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS UP	602	364	All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS DN	593	372	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS UP	601	369	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS DN	591	366	All SZGR 2.0 genes in this pathway
RIGGI EWING SARCOMA PROGENITOR UP	430	288	All SZGR 2.0 genes in this pathway
ACEVEDO METHYLATED IN LIVER CANCER DN	940	425	All SZGR 2.0 genes in this pathway
SMID BREAST CANCER RELAPSE IN BONE DN	315	197	All SZGR 2.0 genes in this pathway
SMID BREAST CANCER LUMINAL B DN	564	326	All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL UP	648	398	All SZGR 2.0 genes in this pathway
EHLERS ANEUPLOIDY DN	12	8	All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL UP	260	174	All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL CULTURED VS FRESH UP	425	298	All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR DN	546	362	All SZGR 2.0 genes in this pathway
MIKKELSEN MCV6 LCP WITH H3K4ME3	162	80	All SZGR 2.0 genes in this pathway
LI INDUCED T TO NATURAL KILLER DN	116	83	All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS UP	745	475	All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS DN	553	343	All SZGR 2.0 genes in this pathway
ACEVEDO FGFR1 TARGETS IN PROSTATE CANCER MODEL DN	308	187	All SZGR 2.0 genes in this pathway
NABA PROTEOGLYCANS	35	23	All SZGR 2.0 genes in this pathway
NABA CORE MATRISOME	275	148	All SZGR 2.0 genes in this pathway
NABA MATRISOME	1028	559	All SZGR 2.0 genes in this pathway

Gene Page: PRELP