Gene Page: PRF1
Summary ?
| GeneID | 5551 |
| Symbol | PRF1 |
| Synonyms | FLH2|HPLH2|P1|PFN1|PFP |
| Description | perforin 1 |
| Reference | MIM:170280|HGNC:HGNC:9360|Ensembl:ENSG00000180644|HPRD:01362|Vega:OTTHUMG00000018412 |
| Gene type | protein-coding |
| Map location | 10q22 |
| Pascal p-value | 0.292 |
| Fetal beta | -0.352 |
| DMG | 1 (# studies) |
| eGene | Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:vanEijk_2014 | Genome-wide DNA methylation analysis | This dataset includes 432 differentially methylated CpG sites corresponding to 391 unique transcripts between schizophrenia patients (n=260) and unaffected controls (n=250). | 1 |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg09914304 | 10 | 72362292 | PRF1 | 1.643E-4 | -6.971 | DMG:vanEijk_2014 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs7370564 | 0 | PRF1 | 5551 | 0.11 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| CACNG5 | 0.79 | 0.53 |
| RGS8 | 0.78 | 0.45 |
| CHRNA3 | 0.78 | 0.24 |
| TANC1 | 0.78 | 0.70 |
| SLC35D3 | 0.77 | 0.44 |
| C1orf127 | 0.77 | 0.39 |
| FAM19A4 | 0.76 | 0.45 |
| NEXN | 0.76 | 0.47 |
| RGS3 | 0.76 | 0.48 |
| TTC39A | 0.76 | 0.41 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| SLC26A4 | -0.33 | -0.37 |
| EMX1 | -0.28 | -0.34 |
| EMID1 | -0.27 | -0.30 |
| IER5L | -0.27 | -0.29 |
| NPAS1 | -0.26 | -0.26 |
| GPR22 | -0.25 | -0.32 |
| DPP4 | -0.25 | -0.28 |
| WDR86 | -0.25 | -0.22 |
| RTN4RL2 | -0.25 | -0.08 |
| MEIS3P2 | -0.25 | -0.16 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG NATURAL KILLER CELL MEDIATED CYTOTOXICITY | 137 | 92 | All SZGR 2.0 genes in this pathway |
| KEGG TYPE I DIABETES MELLITUS | 44 | 38 | All SZGR 2.0 genes in this pathway |
| KEGG AUTOIMMUNE THYROID DISEASE | 53 | 49 | All SZGR 2.0 genes in this pathway |
| KEGG ALLOGRAFT REJECTION | 38 | 34 | All SZGR 2.0 genes in this pathway |
| KEGG GRAFT VERSUS HOST DISEASE | 42 | 31 | All SZGR 2.0 genes in this pathway |
| KEGG VIRAL MYOCARDITIS | 73 | 58 | All SZGR 2.0 genes in this pathway |
| BIOCARTA CASPASE PATHWAY | 23 | 15 | All SZGR 2.0 genes in this pathway |
| BIOCARTA CTL PATHWAY | 15 | 11 | All SZGR 2.0 genes in this pathway |
| BIOCARTA D4GDI PATHWAY | 13 | 8 | All SZGR 2.0 genes in this pathway |
| BIOCARTA SET PATHWAY | 11 | 6 | All SZGR 2.0 genes in this pathway |
| SA CASPASE CASCADE | 19 | 13 | All SZGR 2.0 genes in this pathway |
| PID CD8 TCR PATHWAY | 53 | 42 | All SZGR 2.0 genes in this pathway |
| PID CASPASE PATHWAY | 52 | 39 | All SZGR 2.0 genes in this pathway |
| PID IL2 STAT5 PATHWAY | 30 | 23 | All SZGR 2.0 genes in this pathway |
| PID CD8 TCR DOWNSTREAM PATHWAY | 65 | 56 | All SZGR 2.0 genes in this pathway |
| PID IL12 STAT4 PATHWAY | 33 | 29 | All SZGR 2.0 genes in this pathway |
| CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA UP | 177 | 110 | All SZGR 2.0 genes in this pathway |
| HUTTMANN B CLL POOR SURVIVAL UP | 276 | 187 | All SZGR 2.0 genes in this pathway |
| DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA DN | 320 | 184 | All SZGR 2.0 genes in this pathway |
| GRABARCZYK BCL11B TARGETS UP | 81 | 40 | All SZGR 2.0 genes in this pathway |
| OSMAN BLADDER CANCER UP | 404 | 246 | All SZGR 2.0 genes in this pathway |
| MULLIGHAN MLL SIGNATURE 1 DN | 242 | 165 | All SZGR 2.0 genes in this pathway |
| MULLIGHAN MLL SIGNATURE 2 DN | 281 | 186 | All SZGR 2.0 genes in this pathway |
| JAATINEN HEMATOPOIETIC STEM CELL DN | 226 | 132 | All SZGR 2.0 genes in this pathway |
| DODD NASOPHARYNGEAL CARCINOMA DN | 1375 | 806 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP | 552 | 347 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN RESPONSE TO MC AND SERUM DEPRIVATION UP | 211 | 136 | All SZGR 2.0 genes in this pathway |
| RICKMAN METASTASIS DN | 261 | 155 | All SZGR 2.0 genes in this pathway |
| CHEOK RESPONSE TO MERCAPTOPURINE DN | 22 | 15 | All SZGR 2.0 genes in this pathway |
| MATSUDA NATURAL KILLER DIFFERENTIATION | 475 | 313 | All SZGR 2.0 genes in this pathway |
| GAVIN FOXP3 TARGETS CLUSTER P7 | 90 | 52 | All SZGR 2.0 genes in this pathway |
| HELLER SILENCED BY METHYLATION UP | 282 | 183 | All SZGR 2.0 genes in this pathway |
| WALLACE PROSTATE CANCER RACE UP | 299 | 167 | All SZGR 2.0 genes in this pathway |
| SMID BREAST CANCER NORMAL LIKE UP | 476 | 285 | All SZGR 2.0 genes in this pathway |
| GOLDRATH ANTIGEN RESPONSE | 346 | 192 | All SZGR 2.0 genes in this pathway |
| FIGUEROA AML METHYLATION CLUSTER 1 DN | 48 | 30 | All SZGR 2.0 genes in this pathway |
| BOSCO TH1 CYTOTOXIC MODULE | 114 | 62 | All SZGR 2.0 genes in this pathway |
| WARTERS RESPONSE TO IR SKIN | 83 | 44 | All SZGR 2.0 genes in this pathway |