Gene Page: DDX43
Summary ?
| GeneID | 55510 |
| Symbol | DDX43 |
| Synonyms | CT13|HAGE |
| Description | DEAD-box helicase 43 |
| Reference | MIM:606286|HGNC:HGNC:18677|Ensembl:ENSG00000080007|HPRD:10448|Vega:OTTHUMG00000015033 |
| Gene type | protein-coding |
| Map location | 6q13 |
| Pascal p-value | 0.645 |
| Fetal beta | -0.072 |
| eGene | Anterior cingulate cortex BA24 Cerebellum Frontal Cortex BA9 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs137944725 | 6 | 74052031 | DDX43 | ENSG00000080007.6 | 5.93346E-7 | 0.02 | -55381 | gtex_brain_ba24 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| INO80 | 0.92 | 0.92 |
| TADA2L | 0.90 | 0.91 |
| SFRS15 | 0.90 | 0.90 |
| SETD5 | 0.90 | 0.92 |
| CDC2L5 | 0.90 | 0.91 |
| ZC3H11A | 0.90 | 0.91 |
| DIAPH1 | 0.90 | 0.92 |
| BRD2 | 0.90 | 0.90 |
| POLS | 0.89 | 0.91 |
| TERF2 | 0.89 | 0.91 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.31 | -0.78 | -0.82 |
| MT-CO2 | -0.77 | -0.81 |
| HIGD1B | -0.75 | -0.82 |
| IFI27 | -0.73 | -0.80 |
| MT-CYB | -0.73 | -0.76 |
| AF347015.27 | -0.73 | -0.77 |
| AF347015.21 | -0.72 | -0.83 |
| AF347015.8 | -0.72 | -0.78 |
| AF347015.33 | -0.71 | -0.74 |
| FXYD1 | -0.71 | -0.77 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| ROZANOV MMP14 TARGETS UP | 266 | 171 | All SZGR 2.0 genes in this pathway |
| SATO SILENCED BY METHYLATION IN PANCREATIC CANCER 1 | 419 | 273 | All SZGR 2.0 genes in this pathway |
| HELLER SILENCED BY METHYLATION UP | 282 | 183 | All SZGR 2.0 genes in this pathway |
| HELLER HDAC TARGETS SILENCED BY METHYLATION UP | 461 | 298 | All SZGR 2.0 genes in this pathway |
| MCGARVEY SILENCED BY METHYLATION IN COLON CANCER | 42 | 29 | All SZGR 2.0 genes in this pathway |
| PURBEY TARGETS OF CTBP1 NOT SATB1 DN | 448 | 282 | All SZGR 2.0 genes in this pathway |