Gene Page: TMEM55A
Summary ?
| GeneID | 55529 |
| Symbol | TMEM55A |
| Synonyms | - |
| Description | transmembrane protein 55A |
| Reference | MIM:609864|HGNC:HGNC:25452|Ensembl:ENSG00000155099|HPRD:13233|Vega:OTTHUMG00000164019 |
| Gene type | protein-coding |
| Map location | 8q21.3 |
| Pascal p-value | 0.002 |
| Sherlock p-value | 0.311 |
| Fetal beta | -0.663 |
| DMG | 1 (# studies) |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg00288584 | 8 | 92053063 | TMEM55A | 1.04E-6 | -0.305 | 0.007 | DMG:Wockner_2014 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| INTS3 | 0.94 | 0.96 |
| NDST2 | 0.92 | 0.93 |
| HPS4 | 0.92 | 0.93 |
| PRPF40B | 0.92 | 0.92 |
| ZNF862 | 0.92 | 0.92 |
| ERCC3 | 0.91 | 0.92 |
| NXF1 | 0.91 | 0.94 |
| SFRS14 | 0.91 | 0.92 |
| LZTR1 | 0.91 | 0.92 |
| WDR55 | 0.91 | 0.93 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.31 | -0.79 | -0.81 |
| MT-CO2 | -0.77 | -0.80 |
| AF347015.21 | -0.77 | -0.86 |
| AF347015.27 | -0.76 | -0.80 |
| AF347015.8 | -0.74 | -0.79 |
| MT-CYB | -0.73 | -0.76 |
| AF347015.33 | -0.73 | -0.75 |
| IFI27 | -0.71 | -0.73 |
| HIGD1B | -0.71 | -0.76 |
| AF347015.15 | -0.69 | -0.74 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| CHEMNITZ RESPONSE TO PROSTAGLANDIN E2 UP | 146 | 86 | All SZGR 2.0 genes in this pathway |
| NUYTTEN NIPP1 TARGETS UP | 769 | 437 | All SZGR 2.0 genes in this pathway |
| NUYTTEN EZH2 TARGETS UP | 1037 | 673 | All SZGR 2.0 genes in this pathway |
| WEI MIR34A TARGETS | 148 | 97 | All SZGR 2.0 genes in this pathway |
| NIKOLSKY BREAST CANCER 8Q12 Q22 AMPLICON | 132 | 82 | All SZGR 2.0 genes in this pathway |
| COLINA TARGETS OF 4EBP1 AND 4EBP2 | 356 | 214 | All SZGR 2.0 genes in this pathway |
| CHEN METABOLIC SYNDROM NETWORK | 1210 | 725 | All SZGR 2.0 genes in this pathway |
| WANG RESPONSE TO GSK3 INHIBITOR SB216763 UP | 397 | 206 | All SZGR 2.0 genes in this pathway |
| FIGUEROA AML METHYLATION CLUSTER 4 UP | 112 | 64 | All SZGR 2.0 genes in this pathway |
| WIERENGA STAT5A TARGETS DN | 213 | 127 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE LATE | 1137 | 655 | All SZGR 2.0 genes in this pathway |
| FORTSCHEGGER PHF8 TARGETS DN | 784 | 464 | All SZGR 2.0 genes in this pathway |
| RAO BOUND BY SALL4 ISOFORM B | 517 | 302 | All SZGR 2.0 genes in this pathway |