Gene Page: FOXRED1
Summary ?
| GeneID | 55572 |
| Symbol | FOXRED1 |
| Synonyms | FP634|H17 |
| Description | FAD-dependent oxidoreductase domain containing 1 |
| Reference | MIM:613622|HGNC:HGNC:26927|Ensembl:ENSG00000110074|HPRD:13620|Vega:OTTHUMG00000165827 |
| Gene type | protein-coding |
| Map location | 11q24.2 |
| Pascal p-value | 0.031 |
| Sherlock p-value | 0.92 |
| Fetal beta | -0.568 |
| DMG | 1 (# studies) |
| eGene | Anterior cingulate cortex BA24 Caudate basal ganglia Cerebellar Hemisphere Cerebellum Cortex Frontal Cortex BA9 Hypothalamus Nucleus accumbens basal ganglia Putamen basal ganglia Myers' cis & trans Meta |
| Support | CompositeSet |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Jaffe_2016 | Genome-wide DNA methylation analysis | This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. | 1 |
| DNM:Fromer_2014 | Whole Exome Sequencing analysis | This study reported a WES study of 623 schizophrenia trios, reporting DNMs using genomic DNA. |
Section I. Genetics and epigenetics annotation
DNM table
| Gene | Chromosome | Position | Ref | Alt | Transcript | AA change | Mutation type | Sift | CG46 | Trait | Study |
|---|---|---|---|---|---|---|---|---|---|---|---|
| FOXRED1 | chr11 | 126141344 | A | G | NM_017547 NR_037647 NR_037648 | p.33K>R . . | missense intronic npcRNA | Schizophrenia | DNM:Fromer_2014 |
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg01991383 | 11 | 126139007 | FOXRED1 | 3.69E-9 | -0.011 | 2.36E-6 | DMG:Jaffe_2016 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs1946064 | chr11 | 126727946 | FOXRED1 | 55572 | 0.14 | cis | ||
| rs7947480 | chr11 | 126735192 | FOXRED1 | 55572 | 0.15 | cis | ||
| rs574198 | 11 | 126069841 | FOXRED1 | ENSG00000110074.6 | 4.348E-7 | 0.02 | -71491 | gtex_brain_ba24 |
| rs492154 | 11 | 126070614 | FOXRED1 | ENSG00000110074.6 | 9.55E-7 | 0.02 | -70718 | gtex_brain_ba24 |
| rs627911 | 11 | 126072688 | FOXRED1 | ENSG00000110074.6 | 1.013E-6 | 0.02 | -68644 | gtex_brain_ba24 |
| rs676982 | 11 | 126075219 | FOXRED1 | ENSG00000110074.6 | 1.012E-6 | 0.02 | -66113 | gtex_brain_ba24 |
| rs631372 | 11 | 126078501 | FOXRED1 | ENSG00000110074.6 | 1.012E-6 | 0.02 | -62831 | gtex_brain_ba24 |
| rs608367 | 11 | 126080757 | FOXRED1 | ENSG00000110074.6 | 1.035E-6 | 0.02 | -60575 | gtex_brain_ba24 |
| rs587891 | 11 | 126081336 | FOXRED1 | ENSG00000110074.6 | 4.493E-7 | 0.02 | -59996 | gtex_brain_ba24 |
| rs624590 | 11 | 126083337 | FOXRED1 | ENSG00000110074.6 | 1.034E-6 | 0.02 | -57995 | gtex_brain_ba24 |
| rs599647 | 11 | 126085031 | FOXRED1 | ENSG00000110074.6 | 1.034E-6 | 0.02 | -56301 | gtex_brain_ba24 |
| rs633607 | 11 | 126086768 | FOXRED1 | ENSG00000110074.6 | 4.493E-7 | 0.02 | -54564 | gtex_brain_ba24 |
| rs595660 | 11 | 126087038 | FOXRED1 | ENSG00000110074.6 | 1.034E-6 | 0.02 | -54294 | gtex_brain_ba24 |
| rs583093 | 11 | 126091557 | FOXRED1 | ENSG00000110074.6 | 1.034E-6 | 0.02 | -49775 | gtex_brain_ba24 |
| rs12293354 | 11 | 126093098 | FOXRED1 | ENSG00000110074.6 | 4.493E-7 | 0.02 | -48234 | gtex_brain_ba24 |
| rs10790794 | 11 | 126093217 | FOXRED1 | ENSG00000110074.6 | 4.493E-7 | 0.02 | -48115 | gtex_brain_ba24 |
| rs10790795 | 11 | 126095567 | FOXRED1 | ENSG00000110074.6 | 1.034E-6 | 0.02 | -45765 | gtex_brain_ba24 |
| rs10893488 | 11 | 126095747 | FOXRED1 | ENSG00000110074.6 | 4.493E-7 | 0.02 | -45585 | gtex_brain_ba24 |
| rs635413 | 11 | 126099387 | FOXRED1 | ENSG00000110074.6 | 1.033E-6 | 0.02 | -41945 | gtex_brain_ba24 |
| rs1815820 | 11 | 126111520 | FOXRED1 | ENSG00000110074.6 | 4.493E-7 | 0.02 | -29812 | gtex_brain_ba24 |
| rs642137 | 11 | 126114630 | FOXRED1 | ENSG00000110074.6 | 4.493E-7 | 0.02 | -26702 | gtex_brain_ba24 |
| rs538248 | 11 | 126129103 | FOXRED1 | ENSG00000110074.6 | 1.034E-6 | 0.02 | -12229 | gtex_brain_ba24 |
| rs631023 | 11 | 126129150 | FOXRED1 | ENSG00000110074.6 | 1.525E-6 | 0.02 | -12182 | gtex_brain_ba24 |
| rs685409 | 11 | 126130232 | FOXRED1 | ENSG00000110074.6 | 4.493E-7 | 0.02 | -11100 | gtex_brain_ba24 |
| rs638766 | 11 | 126134698 | FOXRED1 | ENSG00000110074.6 | 1.034E-6 | 0.02 | -6634 | gtex_brain_ba24 |
| rs1786702 | 11 | 126139100 | FOXRED1 | ENSG00000110074.6 | 1.034E-6 | 0.02 | -2232 | gtex_brain_ba24 |
| rs1786703 | 11 | 126139313 | FOXRED1 | ENSG00000110074.6 | 6.832E-7 | 0.02 | -2019 | gtex_brain_ba24 |
| rs634696 | 11 | 126140354 | FOXRED1 | ENSG00000110074.6 | 1.034E-6 | 0.02 | -978 | gtex_brain_ba24 |
| rs478309 | 11 | 126140468 | FOXRED1 | ENSG00000110074.6 | 1.034E-6 | 0.02 | -864 | gtex_brain_ba24 |
| rs591163 | 11 | 126148432 | FOXRED1 | ENSG00000110074.6 | 1.045E-6 | 0.02 | 7100 | gtex_brain_ba24 |
| rs672908 | 11 | 126149651 | FOXRED1 | ENSG00000110074.6 | 1.134E-6 | 0.02 | 8319 | gtex_brain_ba24 |
| rs635686 | 11 | 126180999 | FOXRED1 | ENSG00000110074.6 | 1.119E-6 | 0.02 | 39667 | gtex_brain_ba24 |
| rs686305 | 11 | 126187769 | FOXRED1 | ENSG00000110074.6 | 7.128E-7 | 0.02 | 46437 | gtex_brain_ba24 |
| rs530587 | 11 | 126064439 | FOXRED1 | ENSG00000110074.6 | 4.916E-7 | 0 | -76893 | gtex_brain_putamen_basal |
| rs493083 | 11 | 126065861 | FOXRED1 | ENSG00000110074.6 | 3.654E-7 | 0 | -75471 | gtex_brain_putamen_basal |
| rs557206 | 11 | 126065954 | FOXRED1 | ENSG00000110074.6 | 4.192E-7 | 0 | -75378 | gtex_brain_putamen_basal |
| rs549006 | 11 | 126067099 | FOXRED1 | ENSG00000110074.6 | 8.032E-7 | 0 | -74233 | gtex_brain_putamen_basal |
| rs686747 | 11 | 126067245 | FOXRED1 | ENSG00000110074.6 | 3.504E-7 | 0 | -74087 | gtex_brain_putamen_basal |
| rs591073 | 11 | 126067719 | FOXRED1 | ENSG00000110074.6 | 2.869E-7 | 0 | -73613 | gtex_brain_putamen_basal |
| rs604546 | 11 | 126068354 | FOXRED1 | ENSG00000110074.6 | 2.308E-7 | 0 | -72978 | gtex_brain_putamen_basal |
| rs693789 | 11 | 126068642 | FOXRED1 | ENSG00000110074.6 | 1.305E-7 | 0 | -72690 | gtex_brain_putamen_basal |
| rs574198 | 11 | 126069841 | FOXRED1 | ENSG00000110074.6 | 9.796E-8 | 0 | -71491 | gtex_brain_putamen_basal |
| rs492154 | 11 | 126070614 | FOXRED1 | ENSG00000110074.6 | 9.587E-7 | 0 | -70718 | gtex_brain_putamen_basal |
| rs627911 | 11 | 126072688 | FOXRED1 | ENSG00000110074.6 | 8.628E-7 | 0 | -68644 | gtex_brain_putamen_basal |
| rs676982 | 11 | 126075219 | FOXRED1 | ENSG00000110074.6 | 8.633E-7 | 0 | -66113 | gtex_brain_putamen_basal |
| rs659551 | 11 | 126076824 | FOXRED1 | ENSG00000110074.6 | 2.109E-6 | 0 | -64508 | gtex_brain_putamen_basal |
| rs631372 | 11 | 126078501 | FOXRED1 | ENSG00000110074.6 | 8.683E-7 | 0 | -62831 | gtex_brain_putamen_basal |
| rs608367 | 11 | 126080757 | FOXRED1 | ENSG00000110074.6 | 7.747E-7 | 0 | -60575 | gtex_brain_putamen_basal |
| rs587891 | 11 | 126081336 | FOXRED1 | ENSG00000110074.6 | 8.467E-8 | 0 | -59996 | gtex_brain_putamen_basal |
| rs624590 | 11 | 126083337 | FOXRED1 | ENSG00000110074.6 | 7.924E-7 | 0 | -57995 | gtex_brain_putamen_basal |
| rs599647 | 11 | 126085031 | FOXRED1 | ENSG00000110074.6 | 7.924E-7 | 0 | -56301 | gtex_brain_putamen_basal |
| rs633607 | 11 | 126086768 | FOXRED1 | ENSG00000110074.6 | 8.467E-8 | 0 | -54564 | gtex_brain_putamen_basal |
| rs595660 | 11 | 126087038 | FOXRED1 | ENSG00000110074.6 | 7.924E-7 | 0 | -54294 | gtex_brain_putamen_basal |
| rs583093 | 11 | 126091557 | FOXRED1 | ENSG00000110074.6 | 7.924E-7 | 0 | -49775 | gtex_brain_putamen_basal |
| rs12293354 | 11 | 126093098 | FOXRED1 | ENSG00000110074.6 | 8.467E-8 | 0 | -48234 | gtex_brain_putamen_basal |
| rs10790794 | 11 | 126093217 | FOXRED1 | ENSG00000110074.6 | 8.467E-8 | 0 | -48115 | gtex_brain_putamen_basal |
| rs10790795 | 11 | 126095567 | FOXRED1 | ENSG00000110074.6 | 7.924E-7 | 0 | -45765 | gtex_brain_putamen_basal |
| rs10893488 | 11 | 126095747 | FOXRED1 | ENSG00000110074.6 | 8.481E-8 | 0 | -45585 | gtex_brain_putamen_basal |
| rs635413 | 11 | 126099387 | FOXRED1 | ENSG00000110074.6 | 2.802E-7 | 0 | -41945 | gtex_brain_putamen_basal |
| rs675412 | 11 | 126103368 | FOXRED1 | ENSG00000110074.6 | 1.889E-6 | 0 | -37964 | gtex_brain_putamen_basal |
| rs1815820 | 11 | 126111520 | FOXRED1 | ENSG00000110074.6 | 8.544E-8 | 0 | -29812 | gtex_brain_putamen_basal |
| rs642137 | 11 | 126114630 | FOXRED1 | ENSG00000110074.6 | 8.54E-8 | 0 | -26702 | gtex_brain_putamen_basal |
| rs538248 | 11 | 126129103 | FOXRED1 | ENSG00000110074.6 | 7.924E-7 | 0 | -12229 | gtex_brain_putamen_basal |
| rs631023 | 11 | 126129150 | FOXRED1 | ENSG00000110074.6 | 7.36E-8 | 0 | -12182 | gtex_brain_putamen_basal |
| rs685409 | 11 | 126130232 | FOXRED1 | ENSG00000110074.6 | 8.467E-8 | 0 | -11100 | gtex_brain_putamen_basal |
| rs638766 | 11 | 126134698 | FOXRED1 | ENSG00000110074.6 | 7.924E-7 | 0 | -6634 | gtex_brain_putamen_basal |
| rs1786702 | 11 | 126139100 | FOXRED1 | ENSG00000110074.6 | 7.924E-7 | 0 | -2232 | gtex_brain_putamen_basal |
| rs1786703 | 11 | 126139313 | FOXRED1 | ENSG00000110074.6 | 6.813E-7 | 0 | -2019 | gtex_brain_putamen_basal |
| rs634696 | 11 | 126140354 | FOXRED1 | ENSG00000110074.6 | 7.762E-7 | 0 | -978 | gtex_brain_putamen_basal |
| rs478309 | 11 | 126140468 | FOXRED1 | ENSG00000110074.6 | 7.743E-7 | 0 | -864 | gtex_brain_putamen_basal |
| rs591163 | 11 | 126148432 | FOXRED1 | ENSG00000110074.6 | 6.579E-7 | 0 | 7100 | gtex_brain_putamen_basal |
| rs672908 | 11 | 126149651 | FOXRED1 | ENSG00000110074.6 | 5.425E-7 | 0 | 8319 | gtex_brain_putamen_basal |
| rs8177347 | 11 | 126151761 | FOXRED1 | ENSG00000110074.6 | 3.808E-7 | 0 | 10429 | gtex_brain_putamen_basal |
| rs8177348 | 11 | 126153179 | FOXRED1 | ENSG00000110074.6 | 1.443E-6 | 0 | 11847 | gtex_brain_putamen_basal |
| rs614700 | 11 | 126161490 | FOXRED1 | ENSG00000110074.6 | 3.519E-7 | 0 | 20158 | gtex_brain_putamen_basal |
| rs609634 | 11 | 126163124 | FOXRED1 | ENSG00000110074.6 | 1.223E-7 | 0 | 21792 | gtex_brain_putamen_basal |
| rs611953 | 11 | 126163691 | FOXRED1 | ENSG00000110074.6 | 1.696E-7 | 0 | 22359 | gtex_brain_putamen_basal |
| rs625413 | 11 | 126164349 | FOXRED1 | ENSG00000110074.6 | 2.996E-8 | 0 | 23017 | gtex_brain_putamen_basal |
| rs1695741 | 11 | 126166577 | FOXRED1 | ENSG00000110074.6 | 2.522E-7 | 0 | 25245 | gtex_brain_putamen_basal |
| rs8177386 | 11 | 126167135 | FOXRED1 | ENSG00000110074.6 | 3.934E-7 | 0 | 25803 | gtex_brain_putamen_basal |
| rs682991 | 11 | 126167696 | FOXRED1 | ENSG00000110074.6 | 4.008E-8 | 0 | 26364 | gtex_brain_putamen_basal |
| rs2962117 | 11 | 126168362 | FOXRED1 | ENSG00000110074.6 | 9.391E-7 | 0 | 27030 | gtex_brain_putamen_basal |
| rs2962116 | 11 | 126169009 | FOXRED1 | ENSG00000110074.6 | 2.18E-7 | 0 | 27677 | gtex_brain_putamen_basal |
| rs637462 | 11 | 126176578 | FOXRED1 | ENSG00000110074.6 | 9.302E-7 | 0 | 35246 | gtex_brain_putamen_basal |
| rs686305 | 11 | 126187769 | FOXRED1 | ENSG00000110074.6 | 1.531E-6 | 0 | 46437 | gtex_brain_putamen_basal |
| rs659456 | 11 | 126192524 | FOXRED1 | ENSG00000110074.6 | 2.019E-7 | 0 | 51192 | gtex_brain_putamen_basal |
| rs61524268 | 11 | 126195103 | FOXRED1 | ENSG00000110074.6 | 2.991E-7 | 0 | 53771 | gtex_brain_putamen_basal |
| rs603758 | 11 | 126203737 | FOXRED1 | ENSG00000110074.6 | 4.945E-7 | 0 | 62405 | gtex_brain_putamen_basal |
| rs593526 | 11 | 126204043 | FOXRED1 | ENSG00000110074.6 | 2.495E-7 | 0 | 62711 | gtex_brain_putamen_basal |
| rs582037 | 11 | 126217870 | FOXRED1 | ENSG00000110074.6 | 1.52E-6 | 0 | 76538 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| WANG LMO4 TARGETS UP | 372 | 227 | All SZGR 2.0 genes in this pathway |
| LASTOWSKA NEUROBLASTOMA COPY NUMBER DN | 800 | 473 | All SZGR 2.0 genes in this pathway |
| BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS | 882 | 572 | All SZGR 2.0 genes in this pathway |
| DOUGLAS BMI1 TARGETS DN | 314 | 188 | All SZGR 2.0 genes in this pathway |
| TOYOTA TARGETS OF MIR34B AND MIR34C | 463 | 262 | All SZGR 2.0 genes in this pathway |
| LEE BMP2 TARGETS DN | 882 | 538 | All SZGR 2.0 genes in this pathway |