Gene Page: RNPC3

Summary ?
GeneID55599
SymbolRNPC3
SynonymsRBM40|RNP|SNRNP65
DescriptionRNA binding region (RNP1, RRM) containing 3
ReferenceHGNC:HGNC:18666|Ensembl:ENSG00000185946|HPRD:15267|Vega:OTTHUMG00000166613
Gene typeprotein-coding
Map location1p21
Pascal p-value0.214
Fetal beta1.032
DMG1 (# studies)
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 2

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg083110921104068419RNPC32.11E-8-0.0197.22E-6DMG:Jaffe_2016
cg244066911104068664RNPC33.67E-8-0.011.06E-5DMG:Jaffe_2016

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs1862370chr5164911932RNPC3555990.13trans
rs11200847chr1085855451RNPC3555990.06trans
rs4366501chr11133380324RNPC3555990.05trans
rs6139449chr204496373RNPC3555990.18trans
rs768323chr2122975883RNPC3555990.13trans
rs6638955chrX9684777RNPC3555990.12trans
rs10521608chrX10043330RNPC3555990.02trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
RSPRY10.960.94
RAF10.950.93
KDM4A0.950.93
XPO50.950.94
GART0.950.93
TRAFD10.950.91
USP100.950.92
EDC30.950.93
INTS40.950.91
MED170.950.92
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
MT-CO2-0.80-0.90
AF347015.31-0.79-0.89
AF347015.27-0.79-0.88
AF347015.33-0.78-0.88
AIFM3-0.77-0.80
HLA-F-0.77-0.79
MT-CYB-0.77-0.88
AF347015.8-0.76-0.90
C5orf53-0.75-0.75
FXYD1-0.75-0.86

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
THUM SYSTOLIC HEART FAILURE DN 244147All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER UP 404246All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC DN 537339All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP 552347All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142669All SZGR 2.0 genes in this pathway
TONG INTERACT WITH PTTG1 5732All SZGR 2.0 genes in this pathway
BENPORATH CYCLING GENES 648385All SZGR 2.0 genes in this pathway
GEORGES TARGETS OF MIR192 AND MIR215 893528All SZGR 2.0 genes in this pathway
NOUZOVA TRETINOIN AND H4 ACETYLATION 14385All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN 830547All SZGR 2.0 genes in this pathway
KONDO EZH2 TARGETS 245148All SZGR 2.0 genes in this pathway
CHANDRAN METASTASIS UP 221135All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE G1 S 14776All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE DN 841431All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D 658397All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839928All SZGR 2.0 genes in this pathway