Summary ?
GeneID55600
SymbolITLN1
SynonymsHL-1|HL1|INTL|ITLN|LFR|hIntL|omentin
Descriptionintelectin 1
ReferenceMIM:609873|HGNC:HGNC:18259|Ensembl:ENSG00000179914|HPRD:17165|Vega:OTTHUMG00000028604
Gene typeprotein-coding
Map location1q21.3
eGeneMyers' cis & trans
Meta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
CV:PheWASPhenome-wide association studies (PheWAS)157 SNPs associated with schizophrenia 1
GSMA_IGenome scan meta-analysisPsr: 0.0235 
GSMA_IIAGenome scan meta-analysis (All samples)Psr: 0.00814 
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 

Section I. Genetics and epigenetics annotation

@CV:PheWAS

SNP IDChromosomePositionAllelePFunctionGeneUp/Down Distance
rs22749101160852046null1.456ITLN1null

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs17385407chr1160473285ITLN1556000.17cis
rs16869851chr420690056ITLN1556000.18trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
PTOV10.950.94
CXXC10.940.94
LRWD10.930.94
CCDC940.930.93
XAB20.920.91
MED220.920.92
ZNF6680.920.94
TOR2A0.920.91
DGCR140.920.92
DVL30.920.92
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.27-0.73-0.83
AF347015.31-0.72-0.81
MT-CO2-0.71-0.81
AF347015.33-0.71-0.81
AF347015.8-0.69-0.81
C5orf53-0.69-0.72
MT-CYB-0.69-0.79
AF347015.21-0.66-0.84
AF347015.15-0.66-0.78
S100B-0.65-0.74

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005102receptor bindingIEANeurotransmitter (GO term level: 4)-
GO:0005529sugar bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001934positive regulation of protein amino acid phosphorylationIDA16531507 
GO:0007165signal transductionIEA-
GO:0009624response to nematodeISS-
GO:0046326positive regulation of glucose importIDA16531507 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
GO:0005886plasma membraneIEA-
GO:0031526brush border membraneISS-
GO:0031225anchored to membraneIEA-
GO:0045121membrane raftISS-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
FALVELLA SMOKERS WITH LUNG CANCER 8052All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL CIS 12877All SZGR 2.0 genes in this pathway
LABBE TGFB1 TARGETS DN 10864All SZGR 2.0 genes in this pathway
CHEN LIVER METABOLISM QTL CIS 9340All SZGR 2.0 genes in this pathway
MIKKELSEN IPS LCP WITH H3K27ME3 107All SZGR 2.0 genes in this pathway
BAUS TFF2 TARGETS UP 3222All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 AND SATB1 DN 180116All SZGR 2.0 genes in this pathway
ACEVEDO FGFR1 TARGETS IN PROSTATE CANCER MODEL DN 308187All SZGR 2.0 genes in this pathway
NABA ECM AFFILIATED 17189All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED 753411All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028559All SZGR 2.0 genes in this pathway